RESUMO
This case of prosthetic valve endocarditis due to Pasteurella dagmatis is the first to be reported in the English language medical literature. The two reported cases of native valve endocarditis due to P dagmatis are reviewed, and the treatment of Pasteurella-induced endocarditis is discussed.
Assuntos
Antibacterianos/uso terapêutico , Valva Aórtica , Endocardite Bacteriana/tratamento farmacológico , Próteses Valvulares Cardíacas/microbiologia , Infecções por Pasteurella/tratamento farmacológico , Pasteurella/isolamento & purificação , Idoso , Bioprótese , Endocardite Bacteriana/diagnóstico , Humanos , Masculino , Infecções por Pasteurella/diagnóstico , Resultado do TratamentoRESUMO
A 47-year-old man who smelled of alcohol presented with a three-day history of sore throat. He had not had fever, nausea, vomiting, diarrhea, rhinorrhea, cough, chest pain, or palpitations. On evaluation in the emergency department, he was found to have tachycardia and an irregular pulse.
Assuntos
Alcoolismo/complicações , Fibrilação Atrial/etiologia , Doença de Graves/complicações , Doença de Graves/diagnóstico , Antitireóideos/uso terapêutico , Fibrilação Atrial/diagnóstico , Infecções por Coxsackievirus/complicações , Diagnóstico Diferencial , Eletrocardiografia , Doença de Graves/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Propiltiouracila/uso terapêutico , Testes de Função TireóideaRESUMO
A 52-year-old woman was admitted to the hospital with a rash, periorbital edema, dysphagia, and muscle weakness. The rash had appeared on the back of her neck nine months earlier, and because she had recently returned from a wildlife preserve on Assateague Island, Maryland, she assumed that it was due to tick bites. Over the next two months, the rash spread to her forehead, back, chest, and upper extremities, and scaly lesions appeared over metacar-pophalangeal joints. Initial laboratory tests indicated that her creatine kinase level was elevated. She was given prednisone and the level decreased. The rash also improved, but in the next two months the muscle weakness worsened. She became feverish and increasingly fatigued, depressed, and irritable. These later symptoms were attributed to the medication, but when she was weaned from it, her rash, weakness, and dysphagia increased. Over the ensuing months, she was given intramuscular injections of methotrexate (up to 25 mg/wk), followed by oral doses of hydroxychloroquine and azathioprine, but the symptoms persisted.
Assuntos
Dermatomiosite/diagnóstico , Antirreumáticos/uso terapêutico , Creatina Quinase/sangue , Dermatomiosite/tratamento farmacológico , Diagnóstico Diferencial , Feminino , Glucocorticoides/uso terapêutico , Humanos , Pessoa de Meia-Idade , Prednisona/uso terapêuticoRESUMO
It was previously reported that nuclear matrix isolated from young rat thymus contained an activity that supported V(D)J recombination at a high efficiency (Dave et al., BIOCHEMISTRY 30: 4763-4767, 1991). A similar type of activity is also detected in the matrix prepared from fetal calf thymus. However, restriction enzyme mapping analyses of the recombined product clearly suggest that the double antibiotic resistance exhibited by the matrix treated plasmid substrate is not a consequence of V(D)J signal sequence recombination.
