Assuntos
Ética Clínica , Saúde Global , Julgamento , Princípios Morais , Tomada de Decisões/ética , Saúde Global/ética , Humanos , Julgamento/éticaAssuntos
Atitude Frente a Saúde , Heurística , Relações Médico-Paciente , Ciência , Recusa de Vacinação/psicologia , Adulto , Vacinas contra COVID-19 , Feminino , Humanos , Masculino , ConfiançaRESUMO
A racemic and scalable enantioselective total synthesis of (+)-waihoensene was accomplished. (+)-Waihoensene belongs to the diterpene natural product family, and it features an angular triquinane substructure motif. Its tetracyclic [6.5.5.5]backbone is all-cis-fused, containing six contiguous stereocenters, four of which are quaternary. These structural features were efficiently installed by means of a diastereoselective radical cyclization, followed by an intramolecular Pauson-Khand reaction, a diastereoselective α-alkylation, and a diastereoselective 1,4-addition reaction. Enantioselectivity was introduced at an early stage, by an asymmetric palladium catalyzed decarboxylative allylation reaction on gram scale.
Assuntos
Infecções por Coronavirus/prevenção & controle , Promoção da Saúde/métodos , Comportamentos de Risco à Saúde , Máscaras , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Ciência , Confiança , COVID-19 , Economia , Humanos , Relações Interpessoais , Autonomia Pessoal , Política , Classe Social , Estados UnidosRESUMO
Microcarriers with the ability to release and catch substances are highly desired metamaterials and difficult to obtain. Herein, we report a straightforward strategy to synthesize these materials by combining silica-biomorphs with mesocrystals. An easy access to microcarrier hulls with covalently bound spiropyrans as light-switchable anchor points is presented.
