Dual-energy x-ray absorptiometry measurement and accuracy of bone mineral after unilateral total hip arthroplasty.

The standard technique for monitoring bone mineral in hip arthroplasty has been dual-energy x-ray absorptiometry (DEXA). The accuracy of DEXA in the cortical bone adjacent to femoral components has not been established. This study evaluated bone mineral in the cortical bone adjacent to the femoral component comparing DEXA and ashing. Seven pairs of human femora from postmortem donors with unilateral hip implants were examined. Twenty-eight ashed core specimens from both the medial and lateral sides were taken. Cortical bone loss was seen to be greater in the proximal and medial regions of the implanted femora. Dual-energy x-ray absorptiometry failed to show an acceptable level of accuracy compared with ash data (r = 0.56; P = .002). It did show relative patterns of bone loss. Bone loss was consistent with implant-induced stress shielding.

Ambulatory activities maintain cortical bone after total hip arthroplasty.

Because periprosthetic bone loss impacts revision total hip arthroplasties and subsequent patient recovery, it is important to understand the consequences of stress shielding. We characterized bone loss attributed to stress shielding by investigating the influence of patient activity and demographics on reductions in cortical bone cross-sectional area, bone mineral density, and bone mineral content. Cortical bone shape, bone mineral content, and bone mineral density were measured in implanted and contralateral nonimplanted cadaveric femurs. Geometric measurements of transverse cross sections were measured with imaging software. Dual energy x-ray absorptiometry measured bone mineral content and bone mineral density. Patient activity was estimated by the mechanical usage score. The mechanical usage score was comprised of the ambulatory components of the Harris hip score. Regression analysis revealed a lower mechanical usage score and patient weight correlated with greater bone loss. Age, implant size, and time in situ did not correlate to bone loss. The implanted femurs were reduced in cross-sectional area and rigidity, and expanded endosteally and periosteally. Principal axis location did not change. Bone loss was more likely to occur uniformly than to change cortical bone distribution. Bone loss was minimized in patients with higher activity levels.

Determining the degree of cortical bone asymmetry in bilateral, nonpathological, human femur pairs.

When testing the effects of a femoral component on cortical bone following total hip arthroplasty, the patient's implanted femur is often compared with his/her contralateral nonimplanted femur, with differences attributed to the femoral component. However, if normal anatomical differences exist between bilateral femurs, they need to be quantified in order to validate whether the differences between implanted and nonimplanted bilateral femurs are due to the implant or possibility due to intrinsic differences before implantation. This study quantified the geometric properties of cortical bone shape between seven pairs of bilateral, cadaveric, human femurs. The null hypothesis tested stated that the bilateral femurs would not be significantly different in cortical bone geometry. Digitized images of cortical bone cross-sections taken at percent biomechanical lengths (levels 1-8) were used to calculate bone geometry measurements. The paired t-test showed that the only significant difference was in the location of principal axes at the most proximal location, level 1 (p = 0.015). All other measurements and levels were not significant with percent differences less than 6.6%. In conclusion, the data supports attributing cortical bone shape differences between implanted and contralateral nonimplanted femurs in levels 2-8 to the presence of the implant when the significant differences are greater than 6.6%.