RESUMO
Blood lead levels (PbB), delta-ALA dehydratase activity (ALAD) and erythrocytic protoporphyrin (EPP) values were studied in heavy wine and spirit drinkers. Results were compared in both groups and with a control group (teetotalers). Results in all cases are expressed as arithmetic means +/- SD. PbB values found in the three groups were statistically different inter se: wine group, 195 +/- 82 microg l(-1); spirits group, 159 +/- 69 microg l(-1); teetotalers, 72 +/- 43 microg l(-1). ALAD was significantly lower in the drinker groups (wine 26.9 plus minus 11.4 U l(-1)and spirits 28.3 plus minus 11.6 U l(-1))vs the control group (48.3 plus minus 13.5 U l(-1)). Differences in EPP levels in the three groups were only significant between the teetotaler and the wine drinker groups. Our findings indicate that, in heavy drinkers (more than 2 liters of wine per day), not only are lead levels increased in the blood but there are also biochemical alterations that affect the heme biosynthetic pathway, which should be taken into account in treatment for alcoholics.
Assuntos
Consumo de Bebidas Alcoólicas/efeitos adversos , Chumbo/sangue , Sintase do Porfobilinogênio/metabolismo , Protoporfirinas/metabolismo , Bebidas Alcoólicas/efeitos adversos , Eritrócitos/efeitos dos fármacos , Eritrócitos/metabolismo , Humanos , MasculinoRESUMO
The relationship between lead levels in blood (PbB) and hormones T3, T4, T4F and TSH were studied in 75 subjects exposed to lead at work. PbB levels in blood were determined by atomic absorption spectrophotometry and hormones by enzymoimmunoassay. Positive and significant correlations among thyroid hormones and TSH vs blood lead level in the ranges 8-50 and 26-50 micro g dl(-1)were found ('r' between 0.304 and 0.621 and 0.431 and 0.619, respectively). At PbB levels between 8 and 26 micro g dl(-1)significant correlation was only found for TSH (r= 0.731). In the range PbB 50-98 micro g dl(-1), 'r' was significant only for T3 (-0.746) and T4 (-0.514). Significant differences were observed in T4 and T4F levels between exposed and non-exposed groups. The results obtained indicate the need for monitoring thyroid hormones and TSH levels in workers exposed to lead.
Assuntos
Intoxicação por Chumbo/sangue , Exposição Ocupacional , Hormônios Tireóideos/sangue , Adulto , Humanos , Chumbo/sangue , Masculino , Pessoa de Meia-Idade , Tireotropina/sangueRESUMO
One hundred samples were randomly selected from urine specimens collected from Buenos Aires University students, 50 males and 50 females, whose ages ranged from 19 to 47 years. Cocaine (COC), cannabinoids (CNNs), amphetamines (AMs), benzodiazepines (BZDs), barbiturates (BBTs), opiates (OPs) and salicylates (SAs) were searched for by ELISA, FPIA, normalized TLC, HPLC and GC/MS techniques. The presence of COC was detected in five samples, CNN in two and SA in twelve. No evidence of AMs, BZDs, BBTs or OPs was found.
Assuntos
Drogas Ilícitas/urina , Transtornos Relacionados ao Uso de Substâncias/urina , Adulto , Anfetaminas/urina , Benzodiazepinas/urina , Canabinoides/urina , Cromatografia Líquida de Alta Pressão , Cromatografia em Camada Fina , Cocaína/urina , Ensaio de Imunoadsorção Enzimática , Feminino , Imunoensaio de Fluorescência por Polarização , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Masculino , Pessoa de Meia-Idade , Entorpecentes/urina , Salicilatos/urina , Estudantes , UniversidadesRESUMO
Twenty eight albino Wistar rats were implanted with two 100 mg lead spheres: 14 received the implant in the peritoneum (P) and 14 in the thigh (T). Variations in the activity of delta-aminolevulinic dehydratase (ALAD), of urinary delta-aminolevulinic acid (ALAU), of hematoporphyrins (HP) and of lead blood levels (BPb) were then determined at 30, 60 and 90 days with respect to basal values. Parallel determinations were performed by the same schedule in 7 rats implanted with two glass beads and in 8 sham animals receiving surgical incision alone. Techniques employed for ALAD were Berlin and Schaller; for ALAU, Tomokuni and Ogata; for HP, Piomelli; and for BPb, atomic absorption spectrophotometry. As indicators of lead presence, HP and ALAU proved better, both in P and in T rats. The replacement of lead buckshot for small game hunting by other less toxic elements is recommended.
Assuntos
Chumbo/sangue , Ferimentos por Arma de Fogo , Ácido Aminolevulínico/metabolismo , Animais , Modelos Animais de Doenças , Granuloma de Corpo Estranho/sangue , Granuloma de Corpo Estranho/etiologia , Granuloma de Corpo Estranho/metabolismo , Hematoporfirinas/metabolismo , Implantes Experimentais , Chumbo/administração & dosagem , Ratos , Ratos WistarAssuntos
Drogas Ilícitas/urina , Detecção do Abuso de Substâncias , Adolescente , Adulto , Argentina , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , EstudantesRESUMO
Se estudiaron los niveles de excreción urinaria de mercurio en 220 sujetos sanos, de ambos sexos, no expuestos laboralmente a dicho metal. Las determinaciones se efectuaron por Espectrofotometría de Absorción Atómica, técnica del vapor frío. Los valores obtenidos fueron procesados por un test no paramétrico, obteniendose un rango de 0 a 14 *g/l para el 95%de la población estudiada
Assuntos
Estudo Comparativo , Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Mercúrio/urina , Espectrofotometria Atômica/métodos , Mercúrio/análise , Intoxicação por Mercúrio/diagnóstico , Espectrofotometria Atômica/instrumentação , ArgentinaRESUMO
Se estudiaron los niveles de excreción urinaria de mercurio en 220 sujetos sanos, de ambos sexos, no expuestos laboralmente a dicho metal. Las determinaciones se efectuaron por Espectrofotometría de Absorción Atómica, técnica del vapor frío. Los valores obtenidos fueron procesados por un test no paramétrico, obteniendose un rango de 0 a 14 *g/l para el 95%de la población estudiada
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Espectrofotometria Atômica/métodos , Mercúrio/urina , Argentina , Espectrofotometria Atômica/instrumentação , Intoxicação por Mercúrio/diagnóstico , Mercúrio/análiseRESUMO
An acute massive epidemic of arsenic poisoning in Argentina involved 718 subjects. Urine samples were obtained from 307. The 49 with urine arsenic 76-500 micrograms/dl and 12 with urine arsenic greater than 500 micrograms/dL received dimercaprol treatment. Symptomatology increased with the urine arsenic with increased diarrhea, vomiting and systemic symptoms at urine arsenic greater than 75 micrograms/dL.
Assuntos
Intoxicação por Arsênico , Arsenitos , Surtos de Doenças , Contaminação de Alimentos , Compostos de Sódio , Adolescente , Adulto , Argentina , Arsênio/urina , Crime , Dimercaprol/uso terapêutico , Feminino , Humanos , Masculino , Carne , Intoxicação/terapia , Intoxicação/urinaAssuntos
Chumbo/sangue , Doenças Profissionais/sangue , Prolactina/sangue , Adulto , Argentina , Humanos , Masculino , Pessoa de Meia-Idade , RadioimunoensaioRESUMO
The presence of organochlorinated pesticides in water samples drawn in the Argentine Antarctic Sector and Atlantic coastline has been proved. In general, these samples showed quantities that varied between a few hundredths of a ppmm to slightly more than 1 ppmm, although in some cases and for certain pesticides, depending on the locations, the levels found were definitely higher. With the exception of Dieldrin, which appeared in only one sample/in what would seem to be its course few hundredths of a ppm, to slightly more than 1 ppmm, although in some cases and for certain pesticides found were the same as those reported in previous investigations. The isolated cases of high pesticide contents in water samples drawn at wharves and of snow in the vicinity of Almirante Brown Base show up clearly the influence of human activity on the contamination of the environment.
