1.
Bioorg Med Chem Lett
; 16(2): 400-3, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16246559
RESUMO
A number of 9-acylamino and 9-sulfonylamino derivatives of minocycline have been synthesized for structure-activity relationship studies. These compounds showed activity against both tetracycline-susceptible and tetracycline-resistant strains. Many of the 9-sulfonylamino derivatives exhibited improved antibacterial activity against a number of tetracycline- and minocycline-resistant Gram-positive pathogens.