RESUMO
Most athletes experience musculoskeletal injuries during their sports activity that require rest at a minimum, and occasionally injuries are severe enough to necessitate surgical repair. Neurosurgeons are often consulted for athletically sustained injuries and prescribe medications for the associated pain. The use of both over-the-counter and prescription nonsteroidal medications is frequently recommended, but recent safety concerns must now be considered. The authors discuss the biochemical pathways of nonsteroidal drugs and review the potentially serious side effects of these medications. They also review the use of natural supplements, which may be a safer, and often as effective, alternative treatment for pain relief.
Assuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Anti-Inflamatórios não Esteroides/uso terapêutico , Traumatismos em Atletas/complicações , Terapias Complementares , Dor/tratamento farmacológico , Dor/etiologia , Medicina Herbária , Humanos , Inflamação/tratamento farmacológico , Inflamação/fisiopatologiaRESUMO
Reformatsky reactions of a phenyl ketone, an alpha-bromoester, zinc dust, and a catalytic amount of iodine in dioxane under high-intensity ultrasound (HIU) irradiation from an ultrasonic probe give high yields of beta-hydroxyesters in short reaction times. A series of alkyl phenyl ketones with increasing steric demands of the alkyl group are evaluated as potential electrophiles for the reactions with several alpha-bromoesters, also having increasing steric demands. The Reformatsky reaction under HIU is found to be concentration dependent.