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2.
Equine Vet J ; 43(5): 618-31, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21615781

RESUMO

The British Equine Veterinary Association (BEVA) was established in 1961 and launched the Equine Veterinary Journal (EVJ) in 1968. This review outlines some of the major advances in equine science and practice that have occurred in that time and the role played by the Journal in facilitating those developments.


Assuntos
Cavalos , Sociedades Científicas/história , Medicina Veterinária/história , Animais , Bibliometria , História do Século XX , História do Século XXI , Sociedades Científicas/tendências , Reino Unido , Medicina Veterinária/tendências
8.
Equine Vet J ; 42(2): 91, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20156241
17.
Equine Vet J ; 36(7): 616-21, 2004 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-15581327

RESUMO

REASONS FOR PERFORMING STUDY: Intrauterine growth retardation (IUGR) impairs post natal adaptive responses and is associated with increased adrenocortical activity in many species. OBJECTIVES: To determine whether a restricted or enhanced intrauterine environment affects neonatal adaptation and adrenocortical function in horses. METHODS: Embryos from large (577 kg) Thoroughbred (TB) mares were transferred to smaller (343 kg) pony (P) mares and vice versa, to create a restricted (TB-in-P, n = 11) or enhanced (P-in-TB, n = 8) intrauterine environment. Control groups (TB-in-TB, n = 8; P-in-P, n = 7) were also included. RESULTS: Thirty foals were born live at full term (range 314-348 days) and 4 (3 TB-in-P, 1 P-in-TB) were stillborn between 275 and 335 days. TB-in-P foals were significantly (P<0.05) lighter than TB-in-TB, but heavier than P-in-P foals. TB-in-P foals took longer to first stand and suck and some had fetlock hyperextension and low (<4 g/l) plasma immunoglobulin G concentrations. Other foal groups showed normal behavioural responses. Haematological parameters were normal in all 4 groups of foals. Plasma ACTH levels were high at birth and plasma cortisol concentrations increased after delivery and returned to baseline within 6 h post partum in all but the TB-in-P foals, which had elevated levels until 48 h post partum. Plasma cortisol concentrations increased in all groups following exogenous ACTH administered on Days 1 and 5 postpartum. CONCLUSIONS: The TB-in-P foals showed IUGR and impaired post natal adaptive responses with basal hypercortisolaemia. POTENTIAL RELEVANCE: Foals born following IUGR may require clinical assistance in the early post natal period, but appear mature with respect to adrenocortical function.


Assuntos
Córtex Suprarrenal/fisiologia , Animais Recém-Nascidos/fisiologia , Desenvolvimento Embrionário/fisiologia , Retardo do Crescimento Fetal/veterinária , Doenças dos Cavalos/fisiopatologia , Cavalos/embriologia , Hormônio Adrenocorticotrópico/sangue , Animais , Animais Recém-Nascidos/sangue , Peso Corporal , Transferência Embrionária/veterinária , Feminino , Retardo do Crescimento Fetal/sangue , Retardo do Crescimento Fetal/fisiopatologia , Idade Gestacional , Doenças dos Cavalos/sangue , Cavalos/sangue , Cavalos/crescimento & desenvolvimento , Hidrocortisona/sangue , Gravidez , Fatores de Tempo
19.
Biol Reprod ; 69(2): 540-8, 2003 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12700198

RESUMO

In pregnant mares during late gestation, little, if any, progesterone (P4) is found in the maternal circulation. Hence, quiescence of the equine uterus is believed to be maintained by metabolites of pregnenolone and P4 known as progestagens, which are produced by the uteroplacental tissues. However, little is known about the ontogeny, distribution, or actual rates of uteroplacental progestagen production in pregnant mares and their fetuses during the second half of pregnancy. Therefore, the present study measured the rates of uteroplacental uptake and output of eight specific progestagens in chronically catheterized, pregnant pony mares from 180 days to term. No significant uteroplacental uptake of any of the eight individual progestagens was observed from the uterine circulation. In contrast, significant uteroplacental uptake was observed for five of the eight individual progestagens from the umbilical circulation, and the uptakes increased toward term. The major uteroplacental progestagen outputs were 5 alpha-pregnane-3,20-dione (5 alphaDHP) and 20 alpha-hydroxy-5 alpha-pregnan-3-one (20 alpha 5P). These were released into both the umbilical and uterine circulations at rates that increased toward term. The majority of the total uteroplacental 20 alpha 5P output was distributed into the uterine circulation at all gestational ages studied. In contrast, distribution of the total uteroplacental 5 alphaDHP output switched from preferential delivery into the uterine circulation before 220 days of gestation to release predominantly into the umbilical circulation after 260 days. These findings demonstrate that uteroplacental progestagen production changes during the second half of gestation, which may have important implications for the maintenance of pregnancy and the onset of labor in the mare.


Assuntos
Cavalos/fisiologia , Placenta/metabolismo , Prenhez/fisiologia , Progestinas/biossíntese , Útero/metabolismo , Animais , Gasometria , Feminino , Feto/metabolismo , Cromatografia Gasosa-Espectrometria de Massas , Gravidez , Progestinas/sangue
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