Chemotherapeutical treatment of basal cell carcinoma with bleomycin via microinfusion of the drug into the skin (MMP®).

BACKGROUND: Bleomycin is a chemotherapeutical drug used to treat several neoplasias, including non-melanoma skin cancer; it is effective in the treatment of basal cell carcinoma (BCC) via intralesional infiltration. Transdermal drug delivery, which includes technologies such as CO2 Laser, Dermapen, Dermaroller and MMP®, delivers the desired medication to treat skin neoplasias and also acts in skin rejuvenation. OBJECTIVE: To treat BCC lesions using bleomycin via MMP®. METHODS: Ninety-eight BCC lesions in different anatomical areas were treated using MMP® technology to administer and uniformly distribute bleomycin throughout the lesion and in the established safety margin. RESULTS: The cure rate after six months was 96.94%; and recurrences were not associated with lesion size and/or depth. Adverse effects were the expected ones. STUDY LIMITATIONS: The follow-up time was only six months. CONCLUSION: This therapeutic route showed to be promising and effective.

Chemotherapeutical treatment of basal cell carcinoma with bleomycin via microinfusion of the drug into the skin (MMP®)

Abstract Background Bleomycin is a chemotherapeutical drug used to treat several neoplasias, including non-melanoma skin cancer; it is effective in the treatment of basal cell carcinoma (BCC) via intralesional infiltration. Transdermal drug delivery, which includes technologies such as CO2 Laser, Dermapen, Dermaroller and MMP®, delivers the desired medication to treat skin neoplasias and also acts in skin rejuvenation. Objective To treat BCC lesions using bleomycin via MMP®. Methods Ninety-eight BCC lesions in different anatomical areas were treated using MMP® technology to administer and uniformly distribute bleomycin throughout the lesion and in the established safety margin. Results The cure rate after six months was 96.94%; and recurrences were not associated with lesion size and/or depth. Adverse effects were the expected ones. Study limitations The follow-up time was only six months. Conclusion This therapeutic route showed to be promising and effective.

Alopecia Areata pós-Covid-19: relação causal ou casual? / Alopecia Areata after COVID-19: causal or casual relationship?

A Covid-19, doença causadora de síndrome gripal e insuficiência respiratória aguda, vem demonstrando provocar danos a diversos outros órgãos e sistemas. Várias manifestações dermatológicas já foram descritas. Relatamos um quadro de alopecia areata (AA) desencadeada possivelmente pela Covid-19 em paciente que, apesar de ter seu RT-PCR para SARS-CoV-2 negativo, apresentou IgM reagente e sintomatologia clássica relacionada à doença. Acreditamos que a Covid-19 possa ter desencadeado resposta imunológica autoimune, com a consequente produção de interferons, que levou ao quadro de AA.

COVID-19, a disease that causes flu-like syndrome and acute respiratory failure, has been shown to cause damage to several other organs and systems. Several dermatological manifestations have been regular. We report a case of Alopecia Areata possibly triggered by COVID-19 in a patient who, despite his negative SARS-COV 2 RT- PCR, presented IgM reactor, in addition to classic symptoms related to the disease. We believe that a COVID-19 can trigger the autoimmune immune response with the consequent production of interferons that led to Alopecia areata.

Relato de caso: edema tardio intermitente e persistente (ETIP) de implante de ácido hialurônico desencadeado pela Covid-19 / Case Report: Persistent, Intermittent Delayed Swelling (PIDS) of Hyaluronic Acid filler, triggered by COVID-19

O edema tardio intermitente e persistente (ETIP) por implante de ácido hialurônico é uma reação inflamatória imunomediada decorrente de fenômenos imunogênicos ao próprio preenchedor bem como de sua capacidade em reter água, configurando assim o edema local. Pode ser desencadeado após infecções virais ou bacterianas. Assim como em muitas doenças infectocontagiosas, a COVID-19 pode vir a apresentar na pele diversos sinais e sintomas que ainda não são completamente compreendidos, porém muitas manifestações cutâneas associadas já foram descritas. Vimos, por meio deste relato de caso, apresentar o ineditismo de uma reação do tipo ETIP, desencadeada pela infecção por Sars-CoV-2.

Persistent Intermittent Delayed Swelling (PIDS) due to hyaluronic acid implantation is an immune-mediated inflammatory reaction resulting from immunogenic phenomena to the filler itself, and its ability to retain water, thus configuring local edema. Viral or bacterial infections can trigger the condition. As with many infectious diseases, COVID-19 may have several signs and symptoms on the skin that are not yet fully understood, but many associated skin manifestations have already been described. Through this case report, we report the novelty of an ETIP-type reaction triggered by SARS-CoV-2 infection.

Observational descriptive study of cutaneous manifestations in patients from Mato Grosso with viral chronic hepatitis

Abstract: BACKGROUND: Extrahepatic manifestations are seen in association with chronic infection by hepatitis B or C virus including cutaneous disorders. The frequency of these findings seems to vary among different places and reports. There is a lack of information about this issue in Brazil. OBJECTIVES: To estimate the prevalence of cutaneous findings affecting HBV or HCV carriers from a reference outpatient unit in Mato Grosso. METHODS: A cross-sectional observational study. RESULTS: 108 patients were studied. 88.9% presented some cutaneous findings but must of them were nonrelated to chronic viral infection. Four patients had cutaneous or autoimmune syndromes that may be HBV or HCV related. CONCLUSION: In our study we found no statistical association between viral hepatitis and skin diseases.

Observational descriptive study of cutaneous manifestations in patients from Mato Grosso with viral chronic hepatitis.

BACKGROUND: Extrahepatic manifestations are seen in association with chronic infection by hepatitis B or C virus including cutaneous disorders. The frequency of these findings seems to vary among different places and reports. There is a lack of information about this issue in Brazil. OBJECTIVES: To estimate the prevalence of cutaneous findings affecting HBV or HCV carriers from a reference outpatient unit in Mato Grosso. METHODS: A cross-sectional observational study. RESULTS: 108 patients were studied. 88.9% presented some cutaneous findings but must of them were nonrelated to chronic viral infection. Four patients had cutaneous or autoimmune syndromes that may be HBV or HCV related. CONCLUSION: In our study we found no statistical association between viral hepatitis and skin diseases.

Ceratodermia palmo- plantar pontuada: revisão, classificação e série de casos / Keratoderma palmo-plantaris: review, classification and report of a case series

Neste trabalho de revisão histórica, atualização, ilustração e apresentação de uma série de acasos de Ceratodermia palmo-plantar, atendidos no serviço de Dermatologia do Hospital Universitário da Universidade Federal de Juiz de Fora, visamos auxiliar na definição, classificação e terapêutica de um tipo especifico de ceratodermia encontrado na prática diária com relativa frequência. Por não ser facilmente diagnosticada , pela dificuldade de classificação, inexperiência ou mesmo falta de conhecimento da existência dessa doença, por vezes esta Ceratodermia é tratada de forma equivocada.