RESUMO
A search for previously undiagnosed congenital rubella (CR) was made on 672 children who had attended psychiatric day treatment, learning, and speech and language centres. This was done by observing the seroresponse of seronegative children to rubella vaccine, since 90% of patients with known CR who are seronegative fail to seroconvert to the vaccine. Of the 225 seronegative children 23 did not seroconvert after a single vaccination. Five of these failed to respond on revaccination. These five children had a high frequency of severe language and learning disability as well as frequent diagnoses of major CNS disorders. It is likely that a far greater number of children in the population studied had CR, since our methods identify only about 20% of those affected. Clinically, a specific diagnosis of CR is helpful in facilitating genetic counselling and in allowing the clinician to offer a more hopeful prognosis.
Assuntos
Hospital Dia , Transtornos do Desenvolvimento da Linguagem/terapia , Transtornos da Linguagem/terapia , Deficiências da Aprendizagem/etiologia , Rubéola (Sarampo Alemão)/congênito , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Deficiências da Aprendizagem/terapia , Masculino , Rubéola (Sarampo Alemão)/diagnóstico , Rubéola (Sarampo Alemão)/psicologia , Escalas de WechslerRESUMO
Two children, age seven and 16 years, are described with the abrupt onset of a pure motor hemiplegia as the initial manifestation of a brain stem neoplasm. Subsequent rapid neurological deterioration localized the lesion to the brain stem and glioblastoma multiforme was diagnosed by surgical biopsy. It is suggested that brain stem gliomas with this unusual presentation are likely to be highly malignant and prone to rapid bulbar deterioration.
Assuntos
Neoplasias Encefálicas/complicações , Tronco Encefálico , Glioblastoma/complicações , Glioma/complicações , Hemiplegia/etiologia , Doença Aguda , Adolescente , Criança , Feminino , Humanos , MasculinoAssuntos
Hipersensibilidade a Drogas/etiologia , Fenitoína/efeitos adversos , Candida/imunologia , Criança , Concanavalina A/farmacologia , Relação Dose-Resposta a Droga , Feminino , Humanos , Ativação Linfocitária , Fenitoína/farmacologia , Fenitoína/uso terapêutico , Fito-Hemaglutininas/farmacologia , Mitógenos de Phytolacca americana/farmacologia , Convulsões/tratamento farmacológicoRESUMO
Head scans in 27 infants were done to compare the value of ultrasonography and computed tomography (CT) in the evaluation of macrocrania and encephalocele. Ultrasonography and CT correlated well with regard to anatomical information, especially in the assessment of the lateral and third ventricles. However, unlike CT, ultrasonography uses no ionizing radiation, is less expensive, eliminates sedation, and reduces artifacts due to motion and metal clips. In conjunction with an initial CT examination, ultrasonography is useful for serial evaluation of the lateral and third ventricles. It can also be helpful in assessing extraventricular fluid collections and suspected encephaloceles.
