Neurobehavioral and hepatic complications induced by acute inhalation exposure to abamectin in female rats of the Wistar strain treated with ginger (Zingiber officinale)

The study we conducted aimed to evaluate the acute toxicity of abamectin (ABM) (pesticide) on liver function and neurobehavioral by using the open field test. As a therapy, we have opted for a treatment based on natural antioxidants ginger extract (Zingiber officinale) mixed with olive oil to see the restorative effects during the experiment. The study was conducted on female Wistar rats. The latter was given an inhalation exposure of abamectin (ABM) at a dose CL50 > 5.04mg/L/1hr each morning for one week. The effects of this exposure showed a drop in body weight gain (g), a significant decrease in the relative and absolute weights liver (gm/100 gm body weight) accompanied by hepatic impairment indicating a significant disturbance of transaminases (AST/ALT), alkaline phosphatase (ALP) activity and significant behavioral changes. Administration of ginger (Zingiber officinale) extract at a dose of 3 ml mixed with olive oil at a dose of 1 ml/kg for 7 days orally (gavages) after inhalation indicates that ginger has a more remarkable and rapid effect on physical and mental health, it acts as a major means of defense and hepato-protective against toxicity.(AU)

Neurobehavioral and hepatic complications induced by acute inhalation exposure to abamectin in female rats of the Wistar strain treated with ginger (Zingiber officinale)

The study we conducted aimed to evaluate the acute toxicity of abamectin (ABM) (pesticide) on liver function and neurobehavioral by using the open field test. As a therapy, we have opted for a treatment based on natural antioxidants ginger extract (Zingiber officinale) mixed with olive oil to see the restorative effects during the experiment. The study was conducted on female Wistar rats. The latter was given an inhalation exposure of abamectin (ABM) at a dose CL50 > 5.04mg/L/1hr each morning for one week. The effects of this exposure showed a drop in body weight gain (g), a significant decrease in the relative and absolute weights liver (gm/100 gm body weight) accompanied by hepatic impairment indicating a significant disturbance of transaminases (AST/ALT), alkaline phosphatase (ALP) activity and significant behavioral changes. Administration of ginger (Zingiber officinale) extract at a dose of 3 ml mixed with olive oil at a dose of 1 ml/kg for 7 days orally (gavages) after inhalation indicates that ginger has a more remarkable and rapid effect on physical and mental health, it acts as a major means of defense and hepato-protective against toxicity.(AU)

Neurobehavioral and hepatic complications induced by acute inhalation exposure to abamectin in female rats of the Wistar strain treated with ginger (Zingiber officinale)

The study we conducted aimed to evaluate the acute toxicity of abamectin (ABM) (pesticide) on liver function and neurobehavioral by using the open field test. As a therapy, we have opted for a treatment based on natural antioxidants ginger extract (Zingiber officinale) mixed with olive oil to see the restorative effects during the experiment. The study was conducted on female Wistar rats. The latter was given an inhalation exposure of abamectin (ABM) at a dose CL50 > 5.04mg/L/1hr each morning for one week. The effects of this exposure showed a drop in body weight gain (g), a significant decrease in the relative and absolute weights liver (gm/100 gm body weight) accompanied by hepatic impairment indicating a significant disturbance of transaminases (AST/ALT), alkaline phosphatase (ALP) activity and significant behavioral changes. Administration of ginger (Zingiber officinale) extract at a dose of 3 ml mixed with olive oil at a dose of 1 ml/kg for 7 days orally (gavages) after inhalation indicates that ginger has a more remarkable and rapid effect on physical and mental health, it acts as a major means of defense and hepato-protective against toxicity.

The effect of oral gavage (force-feeding) administration of fenugreek seeds (Trigonella foenum-graecum L. ) on biochemical and neurobehavioural parameters in male Wistar rats

This study aims to evaluate the effect of fenugreek on biochemical parameters, body weight, and the behavior of male Wistar rats. The purpose of administering the aqueous extract of fenugreek seeds (Trigonella foenum-graecum L) for 30 successive days by oral gavage (force-feeding) at a dose of 250g / l of water is intended to assess, on the one hand, the neurobehavioural effects and on the other hand its effect on some biochemical parameters (glycemia and lipid balance) as well as weight. The behavioral tests performed are the Light/Dark Box tests (LDB) and the Elevated Plus Maze test (EPM). This work indicated that the consumption of the aqueous extract of the seeds of fenugreek is beneficial to stimulate appetite and gain weight, thus decreasing the level of total cholesterol, triglycerides, LDL-C, and a significant increase in HDL-C, also a reduction in blood sugar and a decrease in anxiety.(AU)

The effect of oral gavage (force-feeding) administration of fenugreek seeds (Trigonella foenum-graecum L. ) on biochemical and neurobehavioural parameters in male Wistar rats

This study aims to evaluate the effect of fenugreek on biochemical parameters, body weight, and the behavior of male Wistar rats. The purpose of administering the aqueous extract of fenugreek seeds (Trigonella foenum-graecum L) for 30 successive days by oral gavage (force-feeding) at a dose of 250g / l of water is intended to assess, on the one hand, the neurobehavioural effects and on the other hand its effect on some biochemical parameters (glycemia and lipid balance) as well as weight. The behavioral tests performed are the Light/Dark Box tests (LDB) and the Elevated Plus Maze test (EPM). This work indicated that the consumption of the aqueous extract of the seeds of fenugreek is beneficial to stimulate appetite and gain weight, thus decreasing the level of total cholesterol, triglycerides, LDL-C, and a significant increase in HDL-C, also a reduction in blood sugar and a decrease in anxiety.