RESUMO
OBJECTIVE: Fluoxetine is one of the most common medications used for the treatment of depression. Recent studies have demonstrated the possible effect of this drug on bone. The purpose of this study was to evaluate the effect of flouxetine on bone in Sprague-Dawley rats randomly divided into 3 groups (n = 7). STUDY DESIGN: Two calvarial defects, 5 mm diameter, were prepared in parietal bone. The left defects were filled with natural bovine bone mineral (NBBM) and the right defects were left untreated. The first group did not receive fluoxetine. The second group and the third group received 7.5 mg and 15 mg flouxetine, respectively, daily by gastric gavage. The animals were killed 8 weeks after surgery, and the amount of bone regeneration was evaluated using histometric analysis. RESULTS: The defects showed dose-dependent increase in bone formation. The bone fill length had statistical significant differences between NBBM/flouxetine (15 mg) group and other groups (P < .05). The presence of the NBBM had positive effect on the bone formation in all groups in so far as the maximum amount of the increasing effect was seen in those rats filled with NBBM that received 15 mg flouxetine (P < .05). The minimum bone length in fluoxetine-treated defects was seen in 7.5 mg defects (0.36 mm) CONCLUSION: Fluoxetine may improve the amount of bone regeneration in the rat calvarial defects.
Assuntos
Conservadores da Densidade Óssea/uso terapêutico , Doenças Ósseas/cirurgia , Fluoxetina/uso terapêutico , Osso Parietal/efeitos dos fármacos , Animais , Conservadores da Densidade Óssea/administração & dosagem , Doenças Ósseas/patologia , Matriz Óssea/efeitos dos fármacos , Matriz Óssea/transplante , Regeneração Óssea/efeitos dos fármacos , Substitutos Ósseos/uso terapêutico , Bovinos , Craniotomia , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Fluoxetina/administração & dosagem , Masculino , Minerais/uso terapêutico , Osteoblastos/efeitos dos fármacos , Osteoblastos/patologia , Osteogênese/efeitos dos fármacos , Osso Parietal/patologia , Distribuição Aleatória , Ratos , Ratos Sprague-DawleyRESUMO
Here, we report a family with gigantiform cementomas, bone fractures, and autosomal dominant inheritance. Lesions are composed of benign, lobulated, calcified masses resembling cementum. Identification of a COL1A2 mutation in one patient was a polymorphism of no pathological significance. The subject of gigantiform cementomas and the associated bone disorder is both confusing and complex. Reported familial instances indicate genetic heterogeneity with (1) osteopenia and bone fractures, (2) one form of osteogenesis imperfecta, and (3) a polyostotic diaphyseal bone disorder.
