1.
Bioorg Med Chem Lett
; 14(18): 4651-4, 2004 Sep 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15324882
RESUMO
HIV-1 protease inhibitors (PI's) bearing 1,3,4-oxadiazoles at the P1' position were prepared by a novel method involving the diastereoselective installation of a carboxylic acid and conversion to the P1' heterocycle. The compounds are picomolar inhibitors of native HIV-1 protease, with most of the compounds maintaining excellent antiviral activity against a panel of PI-resistant strains.