1.
Angew Chem Int Ed Engl
; 56(47): 14883-14887, 2017 11 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28926175
RESUMO
Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxinâ 4. The choice of metal catalyst (cobalt- or osmium-based) allowed for the formation of THF rings with either trans or cis stereoselectivity. Fragment union using a modified Julia reaction then enabled the synthesis of an advanced synthetic intermediate containing the EF and G rings of the target.