Power tool injuries to the hand and wrist.

Power tool injuries to the hand and wrist are complex injuries which can have a profound impact on the function of the patient. This article gives an overview of the principles, and provides a systematic approach, to the management and rehabilitation of the injured limb and patient required to minimize future disability.

Synthesis of some quinones of potential antitubercular activity.

Certain phthiocol derivatives of expected bactericidal action have been synthesized. These include the phthiocol moiety condensed with p-hydrazino-salicylic and -benzoic acids and their ethyl esters; phthiocol thiosemicarbazone and isonicotinyl hydrazidehydrazone. In another similar series the methyl group of phthiocol was replaced by carbethoxy, ethyl, butyl and isobutyl groups. Allyl and 1.2-epoxypropyl ethers of phthiocol being of high lipid dispersion were also synthesized.

Synthesis of substituted benzoquinones and naphthoquinones with potential antituberculous activity.

Compounds were prepared through the reaction of benzoquinone, naphthoquinone and 2-methyl-1.4-naphthoquinone with several sulphonamides in common use. It is hoped that incorporation of these bacteriostatic agents with the high lipid solubility of the quinone used may afford a better bacteriostatic activity. Determination of the partition coefficient of some representative samples proved these compounds to have high lipid solubility.

Synthesis of 1.4-naphthoquinones-4-aryl(aroyl)hydrazones of potential antimicrobial activity.

The isolation of phthiocol (3-hydroxy-2-methyl-1.4-naphthoquinone) from the acetone-soluble fat fraction of tubercle bacilli [1, 2] and the confirmation that it had antituberculous activity against H-37 R.V. strain [20] in vitro and in mice [12], prompted the synthesis of some 2-alkyl-3-hydroxy-1.4-naphthoquinone-4-aryl(aroyl)hydrazones as possible tuberculostatic agents.