1.
Chemistry
; 19(45): 15109-14, 2013 Nov 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24014459
2.
J Org Chem
; 77(3): 1566-71, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22283859
RESUMO
The first total synthesis of naturally occurring sacidumlignans A (1), B (2), and D (4) was executed and the absolute configuration of 2 and 4 was determined. A diastereoselective α- methylation of a lactone was used as the key step for the control of the chiral centers of the central lignan core. An acid mediated dehydrative cyclization of an aldehyde to construct the dihydronaphthalene unit of 2 and the aromatization of the intermediate dihydronaphthalene derivative to synthesize 1 are the key reactions employed in this regard.