RESUMO
Over the last decade, there has been a rebirth of interest in wound healing research, partly due to advances in biotechnology leading to the feasibility of producing large quantities of pure, human growth factors thought to be important in the healing process and also due to the recognition that certain new dressing materials have a favorable impact in wound healing. This paper describes some of the newer dressing materials and discusses the basis for the biological effects of these products. As progress continues, it is likely that future approaches will combine the use of dressings with drugs or active agents selected to prevent or treat infection, start or stimulate the healing process, or control the production of scar tissue.
Assuntos
Curativos Biológicos , Curativos Oclusivos , Cicatrização , Curativos Biológicos/história , Substâncias de Crescimento/história , Substâncias de Crescimento/uso terapêutico , História do Século XX , Humanos , Teste de Materiais , Curativos Oclusivos/históriaAssuntos
Cicatrização , Ferimentos e Lesões/fisiopatologia , Hemostasia , Humanos , Inflamação , Pele/fisiopatologiaRESUMO
Guinea pig ear stratum corneum was removed to increasing depths by 1, 3, 6 or 9 strippings with adhesive tape. Increasing ornithine decarboxylase (ODC) activity responses were observed in the epidermis 4.5 hr after wounding with 3, 6 or 9 tape strippings. The kinetics of this ODC response were investigated at intervals including, 2, 4.5, 12, 18, 24 and 72 hr after tape stripping. ODC activity was significantly elevated for 12 hr after 3 or 6 tape strippings and for at least 72 hr after 9 tape strippings. These effects were independent of hair plucking or depilation prior to wounding. This model is potentially useful for comparing the effects of chemical, mechanical and physical stimuli on ODC activity and subsequent polyamine synthesis.
