1.
Org Lett
; 11(11): 2313-6, 2009 Jun 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19435372
RESUMO
The favored (R(S)*,M*) diastereoisomer of 2-aryl-pyridine 1 in the solution state results from intramolecular dipole-dipole interactions. In the crystalline state, intermolecular interactions dominate, and the conformation switches reversibly to (R(S)*,P*). Only racemic 1 exhibits this switching property: enantiomerically pure 1 exists as the (R(S)*,M*) diastereoisomer in both the solution and crystalline state.