Assuntos
Prurido/etiologia , Qualidade de Vida , Síndrome de Sjogren/complicações , Adulto , Idoso , Doença Crônica , Efeitos Psicossociais da Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prurido/diagnóstico , Prurido/psicologia , Síndrome de Sjogren/diagnóstico , Síndrome de Sjogren/psicologia , Inquéritos e QuestionáriosRESUMO
Paraneoplastic itch occurs as the result of a systemic reaction to an underlying malignancy. Paraneoplastic itch is most commonly associated with lymphoproliferative malignancies and solid tumors that result in cholestasis. Paraneoplastic itch may occur in the absence of a primary rash or in association with dermatologic conditions such as erythroderma, acanthosis nigricans, dermatomyositis, Grover's disease, and eruptive seborrheic keratosis. Treatment of paraneoplastic itch is centered on targeting the underlying malignancy responsible for the systemic reaction. In cases of malignancy that are refractive to treatment, other therapies have been found to be effective for paraneoplastic itch, including selective serotonin reuptake inhibitors, mirtazapine, gabapentin, thalidomide, opioids, aprepitant, and histone deacetylase inhibitors.
Assuntos
Analgésicos Opioides/uso terapêutico , Anticonvulsivantes/uso terapêutico , Antidepressivos/uso terapêutico , Neoplasias/terapia , Síndromes Paraneoplásicas/tratamento farmacológico , Prurido/tratamento farmacológico , Acantólise/complicações , Acantólise/tratamento farmacológico , Acantose Nigricans/complicações , Acantose Nigricans/tratamento farmacológico , Aprepitanto , Dermatite Esfoliativa/complicações , Dermatite Esfoliativa/tratamento farmacológico , Dermatomiosite/complicações , Dermatomiosite/tratamento farmacológico , Inibidores de Histona Desacetilases/uso terapêutico , Humanos , Ictiose/complicações , Ictiose/tratamento farmacológico , Imunossupressores/uso terapêutico , Ceratose Seborreica/complicações , Ceratose Seborreica/tratamento farmacológico , Mianserina/análogos & derivados , Mianserina/uso terapêutico , Mirtazapina , Morfolinas/uso terapêutico , Neoplasias/complicações , Antagonistas dos Receptores de Neurocinina-1/uso terapêutico , Síndromes Paraneoplásicas/complicações , Prurido/etiologia , Inibidores Seletivos de Recaptação de Serotonina/uso terapêutico , Talidomida/uso terapêuticoRESUMO
A 71-year-old man presented with numerous pruritic seborrheic keratoses, with an eruptive onset over the course of 3 months. At presentation, he was also found to have hypopigmented tumors diffusely scattered throughout his body that were found to be mycosis fungoides on histologic examination. A theory regarding the pathophysiology of the development of eruptive seborrheic keratoses in the presence of mycosis fungoides is briefly discussed and 10 previous case reports of the Leser-Trélat sign in the setting of mycosis fungoides are reviewed.
Assuntos
Ceratose Seborreica/patologia , Micose Fungoide/patologia , Neoplasias Cutâneas/patologia , Idoso , Humanos , Ceratose Seborreica/etiologia , Masculino , Micose Fungoide/complicações , Neoplasias Cutâneas/complicaçõesRESUMO
Perfluorinated ionomers, in particular Nafion, are an essential component in hydrogen fuel cells, as both the proton exchange membrane and the binder within the catalyst layer. During normal operation of a hydrogen fuel cell, the ionomer will progressively swell and deswell in response to the changes in hydration, resulting in mechanical fatigue and ultimately failure over time. In this study, we have developed and implemented a cantilever bending technique in order to investigate the swelling-induced stresses in biaxially constrained Nafion thin films. When the deflection of a cantilever beam coated with a polymer film is monitored as it is exposed to varying humidity environments, the swelling induced stress-thickness product of the polymer film is measured. By combining the stress-thickness results with a measurement of the swelling strain as a function of humidity, as measured by quartz crystal microbalance (QCM) and X-ray reflectivity (XR), the swelling stress can be determined. An estimate of the Young's modulus of thin Nafion films as a function of relative humidity is obtained. The Young's modulus values indicate orientation of the ionic domains within the polymer films, which were confirmed by grazing incidence small-angle X-ray scattering (GISAXS). This study represents a measurement platform that can be expanded to incorporate novel ionomer systems and fuel cell components to mimic the stress state of a working hydrogen fuel cell.