Is antibiotic prophylaxis ever necessary before transoesophageal echocardiography?

Evidence strongly suggests that antibiotic prophylaxis should not be used routinely for transoesophageal echocardiography for any indication.

Emergency endovascular stent grafting of a traumatic thoracic aortic dissection.

An endovascular stent graft was successfully used in the management of a patient with multiple injuries, who sustained an acute type B dissection of the thoracic aorta. We discuss the multidisciplinary approach taken, the contra-indications of conventional surgery, and the radiological imaging employed. We conclude that stent grafts can be safely deployed without morbidity or mortality in a multiply injured patient.

Comparison of sestamibi, thallium, echocardiography and PET for the detection of hibernating myocardium.

The detection of hibernating myocardium is important because revascularisation results in improved function and prognosis in patients with hibernation but not in those with non-viable myocardium. The primary aim of this study was to compare the diagnostic accuracy of four techniques with respect to hibernation in the same study population with 6-12 months of follow-up. Twenty-five males underwent rest-stress sestamibi and delayed (>18 h) thallium scintigraphy, high-dose dobutamine stress echocardiography and nitrogen-13 ammonia/fluorine-18 fluorodeoxyglucose (NH(3)/FDG) positron emission tomography (PET). The pre-operative ejection fraction was 36.2% (+/-7.3%). Follow-up was 8.1 (+/-2.8) months. Using postoperative improvement in wall motion on echocardiography as the gold standard, 6/34 dysfunctional vascular territories were hibernating. The mean uptake of all tracers was significantly higher in hibernating than in non-viable territories ( P<0.05). Normal perfusion or mismatch on PET (FDG>NH(3) uptake) and the pattern of response to dobutamine on echocardiography were also predictive of recovery ( P<0.001 and P=0.02 respectively). Univariate logistic regression identified sestamibi, ammonia and FDG as independent predictors of hibernation. FDG-PET was, however, the only independent predictor using multivariate analysis. The nuclear techniques had high negative predictive values (NPV) of >or=95% but lower positive predictive values (PPV) of 45%-75% as compared with echocardiography, which had an NPV of 87% and a PPV of 100%. PET was the most powerful predictor of hibernation although the combination of a technique with a high PPV (echocardiography) and a high NPV (PET or sestamibi) may represent the optimal clinical choice.

Herniation of the heart into the right pleura following blunt chest trauma--an unusual presentation.

A 21-year-old male patient had sustained a blunt chest and abdominal trauma during a traffic accident. All the major injuries were on the left side. On the second day, a massive shift of the mediastinum to the right was noted. Further investigations raised the suspicion of herniation of the heart into the right pleural cavity. However, the patient's hemodynamic stability did not fit into the picture. Echocardiography and CT scan helped reinforce our suspicion. Herniation was confirmed at the operation, which was performed through median sternotomy. The patient recovered well without complications.

Performance data and the mortuary register.

OBJECTIVE: To compare departmental records of deaths after cardiac surgery with the hospital's information system. DESIGN: Matched pairs comparisons: (i) historic record compared with current record from another source; (ii) contemporary records from different sources; and (iii) timed records from different sources. SETTING: Regional cardiothoracic units at St George's and St. Thomas's Hospitals. SUBJECTS: 2664 cardiac surgical operations at St George's between January 1992 and June 1994, 215 deaths in the cardiac surgery database at St Thomas's between April 1993 and March 1997, 120 in-hospital deaths received by the mortuary at St George's during June 1999. MAIN OUTCOME MEASURES: The difference in the number of in-hospital deaths from departmental, hospital, and mortuary sources. RESULTS: Four of 2664 operations (0.15%) had been incorrectly coded as leaving hospital alive. Fewer than 80% of the actual number of deaths after cardiac surgery at St Thomas's had been recorded on either the departmental database or the hospital administration system. For 9% of deaths received in the mortuary, it took more than 6 working days for the hospital record to be updated, and at the time of reporting 1 case had not been updated after 14 working days: the date of death was inaccurate in 4/113 (3.5%) of cases. CONCLUSIONS: The mortuary staff can contribute to improving the accuracy of body counts. Death rates and performance data should not be published without statistical peer review.

Effect of acute cigarette smoking on gastric secretion.

The effects of smoking one cigarette on a plateau of submaximal gastric secretion induced by histamine acid phosphate (16 nmol kg-1 h-1 (0.005 mg kg-1 h-1)) were measured in eight normal volunteers and in eight duodenal ulcer subjects. The rate of secretion in both groups fell by 25% without any statistically significant change in pyloric loss or duodenogastric reflux. It is concluded that smoking reduces gastric secretion. The possibility that relative antral hypoacidity induced by regular smoking produces an increase in parietal cell mass via a feedback mechanism mediated by gastrin is discussed: such a mechanism would explain the previously reported positive correlation between maximal gastric secretion of acid and the total dose of cigarettes.

Attitudes of cardiothoracic surgeons in the UK to human immunodeficiency virus.

A survey was carried out into attitudes of cardiothoracic surgeons in the UK to human immunodeficiency virus type 1 (HIV-1) infection associated with clinical situations that would normally have been managed surgically with low operative mortality rates and long median survival times. The survey response rate was 72.4 per cent. In patients with acute valvular insufficiency or with continuing angina despite maximal medical therapy (unstable angina) who were HIV-1 antibody positive, 75.8 and 80.8 per cent, respectively, of surgeons would operate. If the patient had end-stage infection, acquired immune deficiency syndrome (AIDS), 29.7 per cent and 34.7 per cent, respectively, would consider surgical intervention. When asked to perform simple procedures such as open lung biopsy or pleurectomy on a patient with AIDS, more than half of surgeons would operate (52.2 and 65.6 per cent respectively). In patients with operable carcinoma of the lung and asymptomatic HIV-1 infection 52.3 per cent would operate. This fell to 15.0 per cent if the patient had a diagnosis of AIDS. The majority of surgeons (77.2 per cent) felt patients should have an HIV-1 antibody test before operation and this rose to 95.6 per cent if patients were in a high-risk group; 60.2 per cent of surgeons had changed their surgical practice to reduce the risks of blood-borne infection.

HIV-1 infection and cardiothoracic surgery: the difference in attitudes between consultants and junior surgeons in the United Kingdom.

A postal survey was carried out inviting the opinions of consultant and trainee cardiothoracic surgeons on the subject of operating upon patients who are either HIV-1 antibody positive or suffer from full-blown AIDS. The questionnaire contained both cardiac and thoracic clinical situations, all of which under normal circumstances would be managed surgically with low operative mortality and long median survival. The overall response rate was 72.4%. A significantly greater number of consultants replied compared to juniors, 80% and 51.6%, respectively (P less than 0.001). In both groups, surgeons were more likely to operate upon a patient who was HIV-1 antibody positive than one who had AIDS. There were no significant differences in the replies of consultants and juniors to the clinical scenarios presented. However, a greater number of juniors admitted to modifying their surgical practice in the light of the increasing incidence of HIV-1 infection (P less than 0.001). Routine preoperative HIV antibody testing was advocated by 77.8% of consultants and 75% of juniors and this rose to 95.1% and 97%, respectively, if patients were in the traditionally high risk groups. Four consultants admitted that they were already performing routine preoperative HIV antibody screening. This survey emphasized the real concern amongst cardiothoracic surgeons, irrespective of their grade, about HIV-1 infection and the need for both education and clear policy guidelines to deal with this difficult issue.

Hospital mortality and long-term survival after pulmonary resection in the elderly.

We have studied the hospital mortality and long-term survival in two groups of patients: those between 50 and 69 years of age (group 1, n = 136) and those older than 70 years of age (group 2, n = 43). The two groups were similar in terms of the distribution of histological type and postsurgical staging. The patients were treated by either lobectomy or pneumonectomy; the lobectomy rate was similar in both groups: 61% and 51% (not significant). Hospital mortality for group 1 was 4.4% and for group 2, 6.9%. Mortality was higher in both groups after pneumonectomy compared with lobectomy, but this was not significant (group 1, 6.2% versus 1.9%; group 2, 9.1% versus 4.7%). Hospital mortality after pulmonary resection was greater in the elderly, but this was not significant (lobectomy: 1.9% [group 1] versus 4.7% [group 2]; pneumonectomy: 6.2% [group 1] versus 9.1% [group 2]. The overall long-term survival at 2 and 4 years was 62.3% and 50.0% for group 1 and 72.5% and 66.6% for group 2. We suggest that the operative risk in the elderly is not prohibitive and the long-term results are acceptable. Patients should not be denied operation on the basis of age alone.

Rupture of the tracheobronchial tree.

Eleven cases of tracheobronchial rupture are described. Nine were the result of external non-penetrating trauma and all but three had other serious injuries. The remaining two were caused by endobronchial intubation. Of the cases caused by external injury, respiratory tract injury was confined to the cervical trachea in three. Two required tracheostomy and repair and the third was managed conservatively; all made satisfactory recoveries. Intrathoracic rupture was recognised on or soon after admission in three cases. One patient died of uncontrollable pulmonary haemorrhage before he could be operated on; immediate repair gave good long term results in the other two. In three cases rupture of the main bronchus was not recognised until complete obstruction developed three, five, and 12 weeks after the accidents. The strictures were resected and the lung re-expanded. Robertshaw endobronchial tubes ruptured the left main bronchus in two patients undergoing oesophageal surgery. Uneventful recovery followed immediate repair. The difficulty of confirming rupture of a major airway is discussed and the importance of conserving the lung when the diagnosis has been missed is emphasised.

Role of cryoanalgesia in the control of pain after thoracotomy.

Thoracotomy causes severe postoperative pain, which is difficult to manage since the use of systemic analgesics often causes respiratory depression. Cryoanalgesia of the intercostal nerves has been advocated as an effective means of local analgesia without serious side effects. A prospective randomised blind trial to investigate the efficacy of the technique was carried out. A total of 53 patients undergoing thoracotomy were allocated to either the trial or a control group. At thoracotomy the surgeon was informed of the patient's trial allocation. The trial group received one minute of direct cryotherapy to at least five intercostal nerves related to the incision. All patients received methadone via the lumbar epidural route in a dose calculated according to their weight. A linear analogue assessment of postoperative pain was made by the patients as soon as they were sufficiently awake. An independent record of all postoperative analgesia was kept. After discharge from hospital further assessments were made at least six weeks after operation. Statistical analysis of the scores of postoperative pain and analgesic consumption showed that there was no significant difference between the trial and the control group. There was, however, a suggestion of an increase in the long term morbidity, although these figures were not amenable to statistical analysis. Thus is has not been possible to demonstrate a role for cryoanalgesia in the control of post thoracotomy pain.