RESUMO
Oral mucositis induced by conventional cytotoxic cancer therapies is a common and significant clinical problem in oncology. Mucositis symptoms, which include severe pain, may lead to dose reductions and unplanned interruptions of chemotherapy and/or radiotherapy, and often affect patients' quality of life. In addition, ulcerative mucositis represents a risk factor for local or systemic infectious complications that may be life-threatening in immunosuppressed patients. The development of biologically based targeted cancer therapies, which aim to block the growth, spread, and survival of tumors by interfering with specific molecular targets, may have reduced mucosal injury, but did not eliminate it. This article will review the epidemiology, pathobiology, and management of oral mucositis associated with conventional cytotoxic therapies for malignant diseases and will briefly summarize emerging information on oral mucosal injury associated with targeted therapies. Considerations for future research aimed at the development of more efficient and effective supportive care approaches will be presented, with emphasis on the contribution of dental researchers and clinicians in these efforts.
RESUMO
OBJECTIVES: This study evaluates interobserver and intraobserver agreement with respect to the determination of the shape and surface of the condylar head on panoramic views. STUDY DESIGN: Detailed frames (n = 632) were made from preoperative and postoperative panoramic views of 158 consecutive patients, who underwent orthognathic surgery. The intraobserver and interobserver agreement were calculated by using Cohen's kappa. RESULTS: By using Cohen's kappa, the intraobserver agreement was determined to be reasonable or good for surface and shape of the condyle. The interobserver agreement was mediocre or poor for surface and shape of the condyle. CONCLUSION: Because of the subjectivity of using panoramic views to determine the shape and surface of the condylar head, considerable interobserver disagreement is possible.
