RESULTS OF INFLAMMATORY AND IMMUNOLOGICAL PARAMETERS OF THE ORAL CAVITY AFTER CYSTECTOMY WITH DIFFERENT METHODS OF CONNECTING THE EDGES OF THE OPERATED AREA.

OBJECTIVE: The aim: To analyze the results of inflammatory and immunological parameters of the oral cavity after cystectomy with different methods of connecting the edges of the operated area. PATIENTS AND METHODS: Materials and methods: The research was conducted in 87 patients who sought surgical treatment of odontogenic cysts of the jaws. Patients were divided into groups depending on the method of wound closure after surgery. We analyzed the results of laboratory tests (leukocytes, ESR, IL-1ß, IL-6, TNF-α, IL-8, NO synthase, MMP-9). RESULTS: Results: The analysis of the effectiveness of using different methods of approximation of the oral mucosa wound on inflammatory and immunological pa¬rameters showed that when using welding of the edges of the operated area using the EKVZ-300 "Patonmed" apparatus, we get positive results of laboratory indicators of inflammatory markers faster (leukocyte counts are normal on day 30, ESR, IL-1ß - on the 14th day, TNF-α - on the 7th day, IL-6, IL-8, NO synthase, MMP-9 - on the 30th day), that is, healing in such patients is faster than in patients with wound closure with classic suture material or laser. CONCLUSION: Conclusions: When comparing the methods of approximation of postoperative oral mucosa wounds by different methods, based on the results of these inflammatory and immunological parameters, the best results were obtained when using electric welding of tissues. Further research and use of the proposed method will facilitate and shorten the rehabilitation period of patients after surgery.

EVALUATION OF THE TREATMENT EFFECTIVENESS OF GINGIVITIS BY THE ORAL DYSBIOSIS INDEX IN PATIENTS WITH DIFFERENT REACTIONS OF PSYCHOPHYSIOLOGICAL MALADAPTATION.

OBJECTIVE: The aim: The purpose of this study was to evaluate the dynamics of changes of oral cavity dysbiosis index in patients with various reactions of psychophysiological maladaptation after treatment of gingivitis in different observation terms. PATIENTS AND METHODS: Materials and methods: Study was conducted on the basis of Department of Therapeutic Dentistry of Ternopil National Medical University during 1 year from January 2018 till January 2019. The study involved treatment of 58 patients 19-44-years old with gingivitis on a background of different psycho-physiological maladaptation reactions, of whom was formed the I main group (37 people) and the II control group (21 people). For evaluation of the effectiveness of the proposed treatment and prevention complexes, we determined the dynamics of changes of oral cavity dysbiosis index after the treatment of gingivitis at different study times. RESULTS: Results: In patients with gingivitis lysozyme activity increased by 15.02% (p <0.01) and urease activity decreased by 24.46% (p <0.05), according to before-treatment data. In patients of the first group, the oral dysbiosis index decreased in 1.5 times fold with respect to before-treatment data (0.37 ± 0.09 vs. 0.56 ± 0.08, p> 0.05). CONCLUSION: Conclusions: Therefore, as a result of the use of proposed treatment and prevention complex was able to increase the activity of lysozyme and reduce urease activity, which generally improved the oral cavity dysbiosis in the main group, which after 1 year of observation was equal to the medium degree in patients with all types of psychophysiological reactions.