[Chemical anabiosis by aldehydes and protection of organs and tissues from ischemic damage]. / Khimicheskii anabioz al'degidami, zashchita organov i tkanei ot ishemicheskikh povrezhdenii.

The article is devoted to the medical biological problem that is the impact of endogenic aldehyde (methylenglucol) on tissue structures with the purpose of defending them from ischemic damage by reverse reduction of intensity of metabolic reactions, which is conditioned by reverse inhibition of the oxidation processes phosphorylation connected with reduction of losses and adenosine 5-triphosphate forming. It is ascertained that until methylenglucol in the ischemic tissue of concrete organ hasn't reduced to a certain critical level there is still an opportunity to reanimate this organ.

[A microsurgical model of cerebral ischemia]. / Mikrokhirurgicheskaia model' ishemii golovnogo mozga.

Microsurgery was performed on 102 rats of both sexes weighing from 150 to 250 g. Anesthesia was induced by injecting 1% hexenal into the abdominal cavity (1 ml/100 g bw). By median incision of the inferior third of the neck and upper third of the pectoris bone an extrapleural access to the mediastinum was actieved, where the common carotid and subclavian arteries were constricted distally to the branching out of the intrathoracic and proximally to the vertebral arteries. The EEG stopped being recorded at the 23 +/- 5th s, respiration stopped at the 4 +/- 0.3th min of cerebral ischemia. Blood pressure and heart rates, after a brief rise, gradually decreased with ischemia prolongation. Appearance of the EEG and respiration and the ECG and blood pressure after 10 min of cerebral ischemia took place within the first 20 min of the postischemic period. After cerebral ischemia lasting over 10 min all the animals died.

[Experimental protection of the myocardium from anoxic damage by a weak solution of formalin]. / Zashchita miokarda slabym rastvorom formalina ot anoksicheskikh povrezhdenii v éksperimente.

Experiments on 80 noninbred rats and 135 rabbits have demonstrated for the first time the possibility of cardioplegia induction with a 0.25% formaldehyde solution. In experimental heterotopic heart transplantation, cardiac function could be restored by perfusion of donor blood within up to 3 hours after cardioplegia. This was associated with restitution of sinus rhythm and direct electrical excitability, with normalization of the intraventricular pressure (for the model described). Histological, histochemical, electron microscopic and electrophysiological studies have shown that low concentrations of formaldehyde solution inhibit myocardial energy metabolism and reversibly inhibit the enzymatic activity, preventing proteolysis and thus contributing to the preservation of heart viability.

[Respiratory chain of rat heart mitochondria during heart preservation in formaldehyde]. / Dykhatel'naia tsep' mitokhondrii tkani serdtsa krysy pri konservatsii serdtsa formal'degidom.

It has been shown by the method of low-temperature ESR-spectroscopy that partial blocking with formaldehyde of electron intake into the respiratory chain promotes the maintenance of a definite level of oxidation in the respiratory chain carriers and preservation of its nativity.