RESUMO
Electrochemical water decomposition to produce hydrogen is a promising approach for renewable energy storage. It is vital to develop a catalyst with low overpotential, low cost and high stability for hydrogen evolution reaction (HER) under alkaline conditions. Herein, we used a simple hydrothermal method to obtain a AgCo(CO)4 precursor on the surface of carbon fiber paper (CFP). After thermal phosphorization, the self-supporting catalyst AgCoPO4/CFP was obtained, which greatly improved the HER catalytic performance under alkaline conditions. At 10 mA cm-2, it showed an overpotential of 32 mV. The Tafel slope was 34.4 mV dec-1. The high catalytic performance of AgCoPO4/CFP may be due to the hydrophilic surface promoting effective contact with the electrolyte and the synergistic effect of the two metals, which accelerated electron transfer and thus promoted hydrogen evolution reaction. In addition, it showed an outstanding urea oxidation reaction (UOR) activity. After adding 0.5 M urea, the over-potential of the AgCoPO4/CFP assembled electrolytic cell was only 1.45 V when the current density reached 10 mA cm-2, which was much lower than that required for overall water splitting. This work provides a new method for the design and synthesis of efficient HER electrocatalysts.
RESUMO
Nitric oxide (NO)-based cancer therapy has attracted much attention in recent years owing to its broad effects on cancer. Low concentrations of NO stimulate cancer cell progression, while its higher levels induce cell apoptosis, and thus, it has motivated the development of probes for in situ NO release monitoring. In this work, a galactose-modified benzothiadiazole-based fluorescent probe (GalNONP/C) was synthesized as both a NO-responsive nanoprobe and NO prodrug carrier. The probe exhibited far-red emission in the range from 550 to 800 nm, and the response showed acidity preference. The galactose on the probe enabled selective targeting of hepatocellular carcinoma (HCC) cells by binding to the asialoglycoprotein receptor (ASGPR) on the cell surface. The probe also delivered low-molecular weight NO prodrug JS-K into cells and monitored the real-time release of the generated NO. Furthermore, in vivo NO imaging with tumor targeting was demonstrated in HCC orthotopic transplantation nude mice and liver sections. Compared with the control experiment using a probe without NO prodrug loading, higher fluorescence response of NO was detected in the cell (3.0 times) and liver slices of the HCC tumor model (2.7 times). This strategy may pave the way to develop nanoprobes for in situ NO monitoring and therapy evaluation in NO-related cancer therapy.
