An iron treatment trial in an aboriginal community: improving non-adherence.

OBJECTIVE: To compare supervised vs unsupervised oral iron treatment in anaemic Aboriginal children living in a remote community with a 40% prevalence of iron deficiency anaemia. METHODOLOGY: A randomised unblinded clinical trial in children < 6 years presenting to a remote Health Centre with anaemia. Oral iron prescribed as a daily unsupervised dose (group A) was compared to twice weekly supervised administration (group B) over 12 weeks. Parenteral iron (group C) was reserved for failure of oral treatment. RESULTS: Only 3 of 25 children in group A responded to treatment compared to 23 of 26 children in group B (odds ratio = 7.7, 95% confidence interval 2.6-25.0). After six weeks of treatment, the mean haemoglobin rise was 0.96 g/L in group A compared to 10.9 g/L in group B and 12.4 g/L in group C. On entry to the study, 29.4% of subjects were underweight, 33.3% stunted and 35.3% microcephalic. The mean catch-up in weight/height on iron treatment over the study was only 0.28 (0.08, 0.48) Z-scores. CONCLUSIONS: Oral iron as directly observed twice weekly treatment is superior to unsupervised therapy. In view of the poor compliance with unsupervised treatment and the high prevalence of iron deficiency anaemia (along with stunting and microcephaly) in Aboriginal children in northern Australia, we propose to undertake in partnership with communities a nutritional intervention program with a high energy weaning food fortified with micronutrients (iron, vitamin A, zinc, folate) as the most effective strategy to address these nutritional problems in the weaning period.

The casemix system of hospital funding can further disadvantage Aboriginal children.

The Northern Territory Health Service implemented a casemix system of hospital funding in 1996 using national averages and national cost weights as benchmarks for length of stay and funding. Clinicians and health administrators were concerned about the potential of this model to impair health service delivery, especially to children of Aboriginal or Torres Strait Islander (ATSI) descent, whose current poor health has been well described. Data were collected on children aged under 10 years who were discharged from the Royal Darwin Hospital between 1 July 1991 and 30 June 1996 and assigned one of four DRGs (simple pneumonia, bronchitis and asthma, gastroenteritis, nutritional and metabolic disorders). Data collected included age, sex, ethnicity, duration of hospital stay, location of residence and presence of comorbidities. There were significant differences in the proportion of children with multiple comorbidities between ATSI and non-ATSI children, as well as between rural- and urban-dwelling ATSI children. A higher proportion of ATSI compared with non-ATSI children had prolonged hospital stays (22.6% v. 1.5%), with the variables influencing length of stay in ATSI children including "age < 2 years", "living in a remote area", and "presence of two or more comorbidities". These results confirm clinical impressions about disease patterns and length of hospital stay in ATSI children, and highlight the problems of imposing a casemix classification system for a "typical" Australian population on a region with a high proportion of people of ATSI descent.

Excessive rates of childhood mortality in the Northern Territory, 1985-94.

OBJECTIVES: To estimate the post-infant/childhood mortality rate (1-14 years) in the Northern Territory (NT) of Australia. METHODS: A retrospective study of post-infant death in the 10 years 1985-94 inclusive in the NT. RESULTS: Two hundred and forty-four deaths were identified. Compared to a non-Aboriginal, an Aboriginal child was twice as likely to die from accidents, 11 times more likely to die from infection and 3.2 times more likely to die from all causes. Road traffic accidents were the leading cause of accident mortality in Aboriginal children. All children who died in collisions or rollovers were unrestrained. Drowning was the major cause of death amongst non-Aboriginal children aged 1-4 years; none of the residential pools in which drowning occurred had fencing which complied with the recommended Australian fencing standards. Mortality rates from infection were highest in Aboriginal children aged 1-4 years. The overall mortality rate decreased over the 10-year period with a significant reduction in non-Aboriginal but not in Aboriginal children. CONCLUSIONS: NT children aged 1-14 years have higher mortality rates than their Australian counterparts and these are significantly higher in Aboriginal compared to non-Aboriginal children. Legislation and enforcement of isolation pool fencing, car seat restraints and safer driving on rural roads could have a significant impact on reducing accident mortality.

Malnutrition and microcephaly in Australian aboriginal children.

OBJECTIVE: To examine the association between malnutrition and microcephaly in the first two years of life. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: Royal Darwin Hospital (a tertiary referral centre); 157 of 165 previously studied Aboriginal children aged under two years who were admitted with diarrhoea between May 1990 and April 1991. Birth weight, birth length, birth head circumference, admission head circumference and admission nutritional status were examined. Nutritional status was categorised according to World Health Organization (WHO) criteria for wasting (thinness) and stunting (shortness). Microcephaly on admission was defined as a head circumference less than the second percentile on Australian reference charts. Small-for-gestational-age (SGA) and birth microcephaly were defined as being less than the tenth percentile for an Australian hospitalised population, corrected for gestational age at confinement. Low birth weight (LBW) was defined as less than 2500 g. MAIN OUTCOME MEASURE: Microcephaly on admission. RESULTS: Of the 157 children, 76 (48%) were wasted, 36 (23%) stunted and 37 (24%) microcephalic on admission. A total of 26 (17%) children had been of LBW, 17 (11%) SGA and 21 (13%) microcephalic at birth. On univariate analysis, microcephaly on admission was associated with wasting (crude odds ratio [OR], 3.91; 95% confidence interval [CI], 1.6-9.7; P < 0.005), but not stunting. There were no significant associations between microcephaly on admission and LBW, being SGA, microcephaly at birth, age or sex. With multivariate analysis, birth head circumference was significantly associated with microcephaly on admission (adjusted OR, 3.62; 95% CI, 1.28-10.23; P < 0.05), as was wasting (adjusted OR, 4.38; 95% CI, 1.88-10.20; P < 0.001). CONCLUSIONS: Wasting was significantly associated with microcephaly, independent of intrauterine growth retardation (as measured by being SGA) and LBW. As malnutrition in critical periods of both intra- and extrauterine development may have irreversible effects on intellectual potential and behaviour, the emphasis on improved nutrition must begin during pregnancy, and should continue in infancy and early childhood.

Malnutrition among rural aboriginal children in the Top End of the Northern Territory.

OBJECTIVE: To calculate the minimum prevalence of malnutrition among rural Aboriginal children under two years of age in the Top End of the Northern Territory (NT) using World Health Organization (WHO) criteria. METHODS: We calculated weight-for-height and height-for-age Z-scores (WHO-endorsed references) for all children under two years who were admitted to hospital with diarrhoeal disease between May 1990 and April 1991. Weights recorded 48 hours after admission were used to allow for acute dehydration. Malnutrition was defined in terms of "wasting" and "stunting" when weight-for-height and height-for-age were more than two standard deviations below the median of the WHO reference population. The denominator population was calculated from NT Department of Health and Australian Bureau of Statistics data. RESULTS: From an average population of no more than 480 children under two years, 34% were admitted to hospital at least once with diarrhoeal disease in the 12 months; 59% were malnourished (wasting alone, 36%; stunting alone, 10%; both, 13%). In the study period an estimated minimum of 20% of all Aboriginal children in the Top End were malnourished (wasted, 12%; stunted, 3%; both, 5%). CONCLUSIONS: The 20% prevalence of malnutrition is many times higher than would be expected statistically, and higher than in many underdeveloped countries. International relief agencies regard a prevalence of wasting in children of more than 8% as a nutritional emergency. We urge that programs to alleviate the poor socioeconomic conditions, and mechanisms for early detection and intervention in childhood malnutrition, be offered to Aboriginal communities.