1.
J Am Chem Soc
; 124(45): 13398-9, 2002 Nov 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12418888
RESUMO
A new strategy was developed for the enantiospecific synthesis of aspidosperma alkaloids. The key steps involve a novel ketene-lactonization reaction of a chiral vinyl sulfoxide to efficiently set up the quaternary carbon center, and a tandem Michael addition-alkylation reaction sequence to form the polycyclic core structure. This new strategy was employed in the total synthesis of natural product (+)-aspidospermidine.