RESUMO
An experimentally-clinical assessment of reparative regeneration collagenation of gastroduodenal anastomosis was made. The anastomoses were formed by different ways: the inverted twin-row (classical) and everting one-row anastomosis. It was stated, that tissues repair on suture-line of the everting anastomosis took place faster and better (on a type of primary intention with wound epithelization on 3-5 days). It was specified by comparatively smaller biophysical metabolic disorders in regenerative structures and characteristics of tissues adaptation (broad zone of anatomic alignment of submucous layer of gastric stump and muscular coat of duodenum stump) in anastomosis zone.
Assuntos
Fístula Anastomótica/prevenção & controle , Gastrectomia , Gastroenterostomia , Úlcera Gástrica/cirurgia , Infecção da Ferida Cirúrgica/prevenção & controle , Adulto , Animais , Cães , Duodeno/cirurgia , Feminino , Gastrectomia/efeitos adversos , Gastrectomia/métodos , Gastroenterostomia/efeitos adversos , Gastroenterostomia/métodos , Humanos , Cuidados Intraoperatórios/métodos , Masculino , Pessoa de Meia-Idade , Modelos Animais , Monitorização Fisiológica , Estômago/cirurgia , Técnicas de Sutura , Resultado do Tratamento , CicatrizaçãoRESUMO
Billroth I gastric resection with end-to-end gastroduodenal anasthamosis was carried out to 73 patients with complicated duodenal ulcers using new technologies: duodenal mobilization only to the level of ulcer defect, the use of one-row (uninterrupted or nodal) everted suture with adaptation zone of submucous base of gastric stump and muscle coat of duodenal stump. Good early and long-term results were achieved.
Assuntos
Úlcera Duodenal/cirurgia , Gastroenterostomia/métodos , Úlcera Péptica Perfurada/cirurgia , Adulto , Idoso , Úlcera Duodenal/complicações , Seguimentos , Humanos , Pessoa de Meia-Idade , Úlcera Péptica Perfurada/complicações , Estudos Retrospectivos , Técnicas de Sutura , Fatores de Tempo , Resultado do TratamentoAssuntos
Endotoxemia/metabolismo , Peroxidação de Lipídeos , Peritonite/metabolismo , Fosfolipases A/metabolismo , Animais , Cães , Endotoxemia/sangue , Endotoxemia/etiologia , Endotoxemia/patologia , Intestinos/irrigação sanguínea , Intestinos/patologia , Microcirculação , Peritonite/sangue , Peritonite/complicações , Peritonite/patologia , Fosfolipases A2RESUMO
The chronic experiments on dogs with a peritonitis model showed that drugs possessing antioxidant properties (vitamin E, dimephosphon, xymedone) are capable of decreasing the inflammatory phenomena in abdominal cavity and decreasing the expression of endogenous intoxication, as manifested by a decrease in the plasma toxicity and the content of average-molecular-weight peptides and lipid peroxidation products. The most pronounced positive effect was observed for xymedone. A certain correlation between the effects of antioxidants upon endotoxicosis and free-radical lipid peroxidation reactions was established. This result suggests the therapeutic effect of antioxidants used for the treatment of peritonitis is related to their membrane-stabilizing ability.
