RESUMO
The authors present the results of comparison of clinical, instrumental and histological, immunohistochemical and electron microscopic data on two pigment-free ciliochoroidal tumors. Differential diagnosis was made at each of the above stages of diagnosis. There is evidence that despite the similarity of the clinical syndrome, the spindle-cell type of the histological structure of both tumors, the latter were of various histogenesis. This was confirmed by the results of immunohistochemical and electron microscopic studies. Retrospective analysis of the data of immunohistochemical and echographic studies revealed the distinctive signs that could differentiate these two types of tumors at the stage of clinical and instrumental diagnosis.
Assuntos
Neoplasias do Nervo Óptico/diagnóstico , Pigmentação , Actinas/imunologia , Actinas/metabolismo , Anticorpos Antineoplásicos/análise , Biomarcadores Tumorais/imunologia , Biomarcadores Tumorais/metabolismo , Desmina/imunologia , Desmina/metabolismo , Diagnóstico Diferencial , Humanos , Imuno-Histoquímica/métodos , Masculino , Melaninas/imunologia , Melaninas/metabolismo , Microscopia Eletrônica , Pessoa de Meia-Idade , Monofenol Mono-Oxigenase/imunologia , Monofenol Mono-Oxigenase/metabolismo , Estadiamento de Neoplasias , Neoplasias do Nervo Óptico/metabolismo , Reprodutibilidade dos Testes , Estudos Retrospectivos , Proteínas S100/imunologia , Proteínas S100/metabolismo , Vimentina/imunologia , Vimentina/metabolismoRESUMO
The paper presents the differential diagnostic signs of choroidal tumors, which are revealed by spatial ultrasound analysis of their angioarchitectonics. An algorithm of a study of the angioarchitectonics of choroidal tumors has been developed on the basis of the current ultrasound technologies that can combine B- and 3D-mode grey scale with energy and color Doppler mapping. Fifty-six patients (58 eyes) with various choroidal neoplasms, including 42 patients with choroidal melanomas, 6 with circumscribed choroidal hemangiomas, and 8 (10 eyes) with metastatic choroidal lesion, were examined. Analysis of the results of the study revealed the specific echographic features of each type of a tumor. The proposed procedure of ultrasound analysis makes it possible to expand the spectrum of the analyzed parameters of the angioarchitectonics, to locate spatially, and to trace the association of the neoplasmic vascular bed with the extraocular circulatory system, which is of great importance in choosing an adequate treatment option.
