[Role of leukocyte adhesion in filterability of blood cell suspensions]. / Rol' adgezii leikotsitov v fil'truemosti suspenzii kletok krovi.

We investigated blood cells suspension filterability of 16 donors. The filtration was performed trough 5 microns-pore nuclear filters at constant perfusion pressure 10(5) din/cm2. We estimated also the adherence of leukocytes and platelets on nylon. The adherence of platelets and mononuclear leukocytes reduced the level of the suspension filterability only by 21% (p > 0.05). The presence of nonadhesive polynuclear leukocytes in the suspensions did not change practically their filterability. The addition in the suspensions of adhesive polynuclear leukocytes reduced suspension filterability dramatically.

[Pathogenesis of lower limb diabetic angiopathies in patients with non-insulin-dependent diabetes mellitus]. / K patogenezu diabeticheskikh angiopatii nizhnikh konechnostei u bol'nykh insulinnezavisimym sakharnym diabetom.

Some indices of the system of homeostasis, lipid metabolism, lipid peroxidation (LPO), the levels of IRI, C-peptide, glycosylated Hb and glycemia (on an empty stomach) were investigated in 131 patients with noninsulin dependent diabetes mellitus (the patients ranged in age from 40 to 60). Correlation analysis has shown that derangements in the system of homeostasis, lipid metabolism and LPO are correlated and interrelated, resulting in disorder of the arterial blood flow in the lower limbs and hence to the development and progression of diabetic angiopathies. The authors have proposed a scheme of LPO involvement in the development of lower limb diabetic angiopathies.

[Leukocyte filterability in whole blood]. / Fil'truemost' leikotsitov v tsel'noi krovi.

There was investigated the leukocyte and erythrocyte filtration in blood of 25 donors men. The blood filtration was performed through 5 m pores of nuclear filters at constant perfusion pressure 100 cm H2O. Erythrocytes didn't influence on the leukocyte filtration in blood. Filtration properties of leukocytes together with their number was more important at filtration of blood.

[The filterability of whole blood (the role of leukocytes and erythrocytes)]. / Fil'truemost' tsel'noi krovi (rol' leikotsitov i éritrotsitov).

Filterability of the blood with various red cell and leukocyte concentrations was examined in 17 patients with coronary heart disease. The blood was filtered through a filter with pore diameter of 5 microns under a pressure of 100 cm water column. Blood filterability drastically deteriorated if leukocyte concentrations in the blood increased and depended on the leukocyte filtration characteristics. The number of red cells passed through the filter was in direct proportion with the blood red cell count.

[Hemostasis and lipid metabolism in patients with non-insulin- dependent diabetes mellitus and angiopathy of the lower extremities]. / Gemostaz i lipidnyi obmen u bo'lnykh insulinnezavisimym sakharnym diabetom s angiopatiei nizhnikh konechnostei.

A study of hemostasis and lipid metabolism, a basal level of immunoreactive insulin, hemoglobin A1C was performed in 81 patients with non-insulin-dependent diabetes mellitus and associated angiopathy of the legs. Decompensated stage of the diabetes was characterized by hypercoagulation and hyperlipidemia. Treatment of diabetic angiopathy of the legs should be aimed both at compensation of diabetes and correction of abnormalities in hemostasis and lipid metabolism.

[Characteristics of disturbances in the hemostasis system in patients with insulin-dependent diabetes mellitus with angiopathies of the vessels of the lower extremities]. / Osobennosti narushenii v sisteme gemostaza u bol'nykh insulinnezavisimym tipom sakharnogo diabeta s angiopatiiami sosudov nizhnikh konechnostei.

Indices of the system of hemostasis, the levels of glycolysated hemoglobin were studied in 67 patients suffering from non-insulin-dependent diabetes mellitus with lower limb angiopathies (aged 40 to 60). Rheovasography of the lower limbs was performed. The patients were treated with antidiabetic drugs per os (with the exception of hydroxydione sodium succinate), platelet aggregation inhibitors (pentoxifylline, acetylsalicylic acid) and vasodilators (xanthinol nicotinate, solcoseryl and cinnarizine). The use of pentoxifylline after therapy increased the rate of platelet aggregation inhibition and decreased the prothrombin index, not influencing the other indices of the system of hemostasis. Pentoxifylline combined with acetylsalicylic acid at small doses normalized not only platelet indices but also the other indices of the system of hemostasis. Positive changes in the system of hemostasis were accompanied by a rise of the rheographic index in patients with vascular functional changes. In obliterating atherosclerosis the rheographic index was not on an increase indicating the necessity of corrective therapy of vascular lesions, first of all in the system of hemostasis, in the early period of diabetes mellitus.