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2.
Khirurgiia (Mosk) ; (10): 60-70, 2023.
Artigo em Russo | MEDLINE | ID: mdl-37916559

RESUMO

OBJECTIVE: To analyze the outcomes after different methods of post-resection chest wall defect reconstruction. MATERIAL AND METHODS: The study included 41 patients aged 22-73 years who underwent chest wall repair with local tissues and synthetic materials. Twelve (29.3±7.1%) patients had sarcoma, 9 (21.9±5.9%) - non-small cell lung cancer (NSCLC) with invasion of the chest, 9 (21.9±5.9%) - metastatic lesions, 8 (19.5±6.2%) - benign tumors, 2 (4.8±3.4%) - breast cancer with invasion of the chest wall, 1 (2.4±2.4%) - desmoid tumor. Seven patients were diagnosed with T3N0M0, 1 - T3N2M0, 1 - T2N0M1b (oss). Among patients with NSCLC with invasion into the chest wall, squamous cell cancer was verified in 4 (44.4±16.6%) patients, adenocarcinoma - in 4 (44.4±16.6%), neuroendocrine tumor - in 1 (11.2±10.5%) patient. Stages of surgeries are presented. RESULTS: We analyzed treatment outcomes in 41 patients. Five (12.2%) patients had seroma, hemothorax, thoracopleural fistula, subcutaneous emphysema and fatal asystole. There were no postoperative complications associated with paradoxical breathing. CONCLUSION: Accurate morphological verification prior to treatment is valuable to determine the stages of combined treatment of chest wall tumors. Chest wall defect closure with own tissues and synthetic materials is necessary after extensive resections. A multidisciplinary approach involving thoracic and plastic surgeons is needed.


Assuntos
Carcinoma Pulmonar de Células não Pequenas , Neoplasias Pulmonares , Procedimentos de Cirurgia Plástica , Neoplasias Torácicas , Parede Torácica , Humanos , Parede Torácica/cirurgia , Carcinoma Pulmonar de Células não Pequenas/cirurgia , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/cirurgia , Neoplasias Pulmonares/patologia , Resultado do Tratamento , Neoplasias Torácicas/diagnóstico , Neoplasias Torácicas/cirurgia
3.
Georgian Med News ; (344): 47-52, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-38236098

RESUMO

This article analyses the transformation of Ukrainian healthcare in the context of the new digital healthcare. The study highlights the risks faced by Ukraine's healthcare system and proposes solutions and modernization options to improve the situation.The article conducts a narrative synthesis of related literature with a cross-sectional analysis to analyse the development of Ukrainian telemedicine and its current state in European countries. Risks, such as insufficient financial support, lack of personnel, corruption, and inaccessibility of medical services to the population, are considered.The article goes on to propose solutions to overcome these risks, including attracting additional investment in the healthcare system, improving working conditions for healthcare professionals, and reducing corruption. The article also discusses options for modernization, including the introduction of electronic medical records, the development of telemedicine, and ensuring access to quality healthcare services for all segments of the population. The paper also describes the mechanisms associated with new information and communication technologies, of which telemedicine is a part, to illustrate the potential of this new technology to transform traditional organizational forms of medicine. A brief overview of the role of telemedicine in the Ukrainian healthcare system is presented. An analytical approach is proposed along with a description of five different aspects for the effective use of telemedicine. The conclusion of the article is that the transformation of Ukrainian medicine to the new conditions of digital development requires a comprehensive approach and joint efforts of the government, medical professionals, and the public. Through risks and challenges, there is an opportunity to improve the medical system and provide quality healthcare services to all citizens of Ukraine, especially in regions with active hostilities.


Assuntos
Atenção à Saúde , Telemedicina , Humanos , Estudos Transversais , Ucrânia
4.
Sovrem Tekhnologii Med ; 12(3): 6-10, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34795974

RESUMO

The aim of the study was to describe the boundary between the phases of rapid and slow ejection in the cardiac cycle and to define the exact location of the j point on ECGs. MATERIALS AND METHODS: The work is based on the theory of heart cycle phase analysis using mathematical equations of hemodynamics. The balance of phase diastolic and systolic blood volumes depending on the duration of the cardiac cycle phases has been verified by these equations. The interrelation of phase duration and phase blood volumes was employed to exactly define the cardiac cycle boundaries on ECGs. Synchronous recording of the ECG and rheogram was used to determine the precise location of the j point. RESULTS: The exact boundary between the phases of rapid and slow ejection has been defined. A new point L determining the boundary between SL-Lj phases was introduced for its designation. CONCLUSION: The j point was previously considered to be part of an ECG depending on the body temperature and which does not always appear. It had an ambiguous definition: Osborn wave or j wave. At the same time, the precise boundary between the rapid and slow ejection phases, the blood volumes of which in the total amount are equal to the blood stroke volume, has not been identified exactly. The work performed allows for accurate definition of criteria for recording rapid and slow ejection phases and j point location on the ECG.


Assuntos
Eletrocardiografia , Coração , Diástole , Volume Sistólico , Sístole
5.
Khirurgiia (Mosk) ; (9): 100-102, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34480462

RESUMO

Splenosis is a rare disease and defined as spleen tissue autotransplantation following spleen rupture and subsequent splenectomy in most cases. The authors report ectopic splenic tissue in pleural cavity diagnosed in 31 years after blunt thoracoabdominal trauma.


Assuntos
Esplenose , Humanos , Esplenectomia , Esplenose/diagnóstico , Esplenose/etiologia , Esplenose/cirurgia , Transplante Autólogo
6.
Allergy ; 73(8): 1597-1608, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29377177

RESUMO

Nasal allergen challenge (NAC) is an important tool to diagnose allergic rhinitis. In daily clinical routine, experimentally, or when measuring therapeutic success clinically, nasal allergen challenge is fundamental. It is further one of the key diagnostic tools when initiating specific allergen immunotherapy. So far, national recommendations offered guidance on its execution; however, international divergence left many questions unanswered. These differences in the literature caused EAACI to initiate a task force to answer unmet needs and find a consensus in executing nasal allergen challenge. On the basis of a systematic review containing nasal allergen challenges of the past years, task force members reviewed evidence, discussed open issues, and studied variations of several subjective and objective assessment parameters to propose a standardized way of a nasal allergen challenge procedure in clinical practice. Besides an update on indications, contraindications, and preparations for the test procedure, main recommendations are a bilaterally challenge with standardized allergens, with a spray device offering 0.1 mL per nostril. A systematic catalogue for positivity criteria is given for the variety of established subjective and objective assessment methods as well as a schedule for the challenge procedure. The task force recommends a unified protocol for NAC for daily clinical practice, aiming at eliminating the previous difficulty of comparing NAC results due to unmet needs.


Assuntos
Comitês Consultivos , Alérgenos/administração & dosagem , Testes de Provocação Nasal/normas , Testes de Provocação Nasal/tendências , Rinite Alérgica/diagnóstico , Administração Intranasal , Assistência ao Convalescente , Anafilaxia , Alemanha , Humanos , Imunoglobulina E/sangue , Mucosa Nasal/imunologia , Obstrução Nasal/imunologia , Testes de Provocação Nasal/métodos , Sprays Nasais , Prurido/imunologia , Testes Cutâneos , Espirro/imunologia
7.
Clin Transl Allergy ; 7: 17, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28572918

RESUMO

This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms, recommendations for diagnosis and treatment of AR, and to define the needs in this neglected area by a literature review. AR is a systemic allergic disease and is generally associated with numerous multi-morbid disorders, including asthma, eczema, food allergies, eosinophilic oesophagitis (EoE), conjunctivitis, chronic middle ear effusions, rhinosinusitis, adenoid hypertrophy, olfaction disorders, obstructive sleep apnea, disordered sleep and consequent behavioural and educational effects. This report provides up-to-date usable information to: (1) improve the knowledge and skills of allergists, so as to ultimately improve the overall quality of patient care; (2) to increase interest in this area; and (3) to present a unique contribution to the field of upper inflammatory disease.

8.
Lik Sprava ; (5-6): 14-20, 2015.
Artigo em Russo | MEDLINE | ID: mdl-27089710

RESUMO

The positive clinical, serolgical and immunological effects of Glutamyl-Triptophan in patients on persistent herpes virus infections are shown. Treatment resulted in the increase of avidity on HSV 1, HSV 2, CMV, EBV antibody, the levels of CD3+-, ICD8+-, CD16+-, CD3+HLA-DR+- (%, abs) and.CD3+CD25t-cells (%), that indicates the optimization of the immune systemdata. The data received allow to recommend Bestim for patients with persistent herpes virus infections.


Assuntos
Anticorpos Antivirais/sangue , Antivirais/uso terapêutico , Infecções por Citomegalovirus/tratamento farmacológico , Dipeptídeos/uso terapêutico , Infecções por Vírus Epstein-Barr/tratamento farmacológico , Herpes Genital/tratamento farmacológico , Herpes Simples/tratamento farmacológico , Fatores Imunológicos/uso terapêutico , Aciclovir/análogos & derivados , Aciclovir/uso terapêutico , Adulto , Anticorpos Antivirais/biossíntese , Antígenos CD/genética , Antígenos CD/imunologia , Estudos de Casos e Controles , Doença Crônica , Citomegalovirus/imunologia , Infecções por Citomegalovirus/sangue , Infecções por Citomegalovirus/imunologia , Infecções por Citomegalovirus/virologia , Infecções por Vírus Epstein-Barr/sangue , Infecções por Vírus Epstein-Barr/imunologia , Infecções por Vírus Epstein-Barr/virologia , Feminino , Expressão Gênica , Herpes Genital/sangue , Herpes Genital/imunologia , Herpes Genital/virologia , Herpes Simples/sangue , Herpes Simples/imunologia , Herpes Simples/virologia , Herpesvirus Humano 1/imunologia , Herpesvirus Humano 2/imunologia , Herpesvirus Humano 4/imunologia , Humanos , Imunidade Celular/efeitos dos fármacos , Imunidade Humoral/efeitos dos fármacos , Masculino , Pessoa de Meia-Idade , Linfócitos T/efeitos dos fármacos , Linfócitos T/imunologia , Linfócitos T/virologia , Valaciclovir , Valina/análogos & derivados , Valina/uso terapêutico
9.
Lik Sprava ; (6): 32-7, 2013 Sep.
Artigo em Russo | MEDLINE | ID: mdl-25510086

RESUMO

The antiinflammatory cytokines participate in antiinfective immunity, that is why it is advisable to study their peculiarities in determination of the role in immunologic pathogenesis of pyelonephritis. Of the work is to study the levels of pro-inflammatory blood cytokines in the patients with pyelonephritis (PN), to determine the peculiarities in acute and chronic its course in children and adults. The immuno-enzymic method ELISA and the corresponding test-systems were used to study the levels of cytokines in blood. There were studied the levels of pro-inflammatory cytokines (TNF, MCP and IL-23) in blood serum of patients with acute (APN) and chronic (CPN) pyelonephritis. The analysis showed the reliable increase in levels of all studied findings in both forms of PN--both in all 173 patients and in every group--children (87) and adults (86). The MCP-1 levels in APN are reliably higher than in CPN, while in TNF-b and IL-23--do not differ. The levels of all three cytokines in blood of adults were higher than in children in APN, but TNF--in CPN as well. The high level of TNF, MCP-1 and IL-23 in blood of adults and children confirm their important role both in APN and CPN, but MCP-1 can be considered as a predictor of acute/exacerbation of chronic pyelonephritis. By the findings of the studied cytokines, more expressed immune response was noted in the adults.


Assuntos
Quimiocina CCL2/sangue , Interleucina-23/sangue , Linfotoxina-alfa/sangue , Pielonefrite/sangue , Doença Aguda , Adolescente , Adulto , Biomarcadores/sangue , Quimiocina CCL2/imunologia , Criança , Doença Crônica , Feminino , Humanos , Interleucina-23/imunologia , Linfotoxina-alfa/imunologia , Masculino , Pielonefrite/diagnóstico , Pielonefrite/imunologia , Pielonefrite/fisiopatologia
10.
Lab Chip ; 11(8): 1502-6, 2011 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-21340094

RESUMO

Fluorescence cross-correlation spectroscopy (FCCS) is a highly sensitive fluorescence technique with distinct advantages in many bioanalytical applications involving interaction and binding of multiple components. Due to the use of multiple beams, bulk optical FCCS setups require delicate and complex alignment procedures. We demonstrate the first implementation of dual-color FCCS on a planar, integrated optofluidic chip based on liquid-core waveguides that can guide liquid and light simultaneously. In this configuration, the excitation beams are delivered in predefined locations and automatically aligned within the excitation waveguides. We implement two canonical applications of FCCS in the optofluidic lab-on-chip environment: particle colocalization and binding/dissociation dynamics. Colocalization is demonstrated in the detection and discrimination of single-color and double-color fluorescently labeled nanobeads. FCCS in combination with fluorescence resonance energy transfer (FRET) is used to detect the denaturation process of double-stranded DNA at nanomolar concentration.


Assuntos
Dispositivos Lab-On-A-Chip , Espectrometria de Fluorescência/instrumentação , Cor , DNA/química , Transferência Ressonante de Energia de Fluorescência , Corantes Fluorescentes/química , Nanoestruturas/química , Temperatura
12.
Vestn Otorinolaringol ; (4): 36-9, 2009.
Artigo em Russo | MEDLINE | ID: mdl-19738589

RESUMO

The objective of this study was to analyse the efficiency and safety of the use of a holmium- YAG laser (wave length 2.09 mcm) and an erbium-activated glass-based fiber laser scalpel (wave length 1.56 mcm) in ENT-surgery. Priority methods for the surgical intervention in the nasal cavity, paranasal sinuses, and middle ear were developed to treat patients with distorted nasal septa, vasomotor rhinitis, polypous rhinosinusitis, Eustachian tube dysfunction, and various forms of chronic suppurative otitis media. Long-term observations demonstrated fairly good stability of beneficial outcomes of the treatment with the above methods in the majority of the patients. It is concluded that surgical technologies with the use of modern medical lasers provide extensive possibilities for a great variety of interventions in patients with upper respiratory tract and ear diseases.


Assuntos
Otopatias/cirurgia , Terapia a Laser/instrumentação , Lasers , Procedimentos Cirúrgicos Otorrinolaringológicos/métodos , Doenças Respiratórias/cirurgia , Otopatias/complicações , Humanos , Doenças Respiratórias/complicações , Resultado do Tratamento
14.
Biosens Bioelectron ; 24(11): 3258-63, 2009 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-19443207

RESUMO

We demonstrate detection and analysis of the Qbeta bacteriophage on the single virus level using an integrated optofluidic biosensor. Individual Qbeta phages with masses on the order of attograms were sensed and analyzed on a silicon chip in their natural liquid environment without the need for virus immobilization. The diffusion coefficient of the viruses was extracted from the fluorescence signal by means of fluorescence correlation spectroscopy (FCS) and found to be 15.90+/-1.50 microm(2)/s in excellent agreement with previously published values. The aggregation and disintegration of the phage were also observed. Virus flow velocities determined by FCS were in the 60-300 microm/s range. This study suggests considerable potential for an inexpensive and portable sensor capable of discrimination between viruses of different sizes.


Assuntos
Técnicas Biossensoriais/instrumentação , Colífagos/isolamento & purificação , Análise de Injeção de Fluxo/instrumentação , Técnicas Analíticas Microfluídicas/instrumentação , Dispositivos Ópticos , Espectrometria de Fluorescência/instrumentação , Análise de Falha de Equipamento , Sensibilidade e Especificidade , Espectrometria de Fluorescência/métodos
16.
Voen Med Zh ; 327(9): 33-7, 96, 2006 Sep.
Artigo em Russo | MEDLINE | ID: mdl-17180856

RESUMO

The elaboration of more reliable and simple methods of transmitted and plexus anestesias has provided a wide clinical usage of regionar anestesia (RA) during the operations on extremities. The creation of devices to identificate (locate) nerval bearer and plexes was also an important factor for increasing quantity of RA. For such identification we use the portable "Innervator 232" neurostimulator manufactured by "Fisher & Paykel Ltd.", New Zealand. Successful conduction of transmitted and plexus anesthesia depends a lot on anesthesiologist's knowledge of anatomy-topography location of nerval bearer and plexes, precise fulfillment of anesthesia, manual capabilities of physician and obtaining a paresthesia or muscular contraction during the identification of nerval bearer with the help of neurostimulator. RA is secure, effective, and provides less risk for a patient. With neurostimulation the amount of successful anesthesias increases up to 98%. The neurostimulator is easy to use, clinically effective in emergency and planned surgeries for identification of nerval bearer and plexes.


Assuntos
Anestesia Local/métodos , Estimulação Elétrica/instrumentação , Extremidades/cirurgia , Nervos Periféricos/fisiologia , Anestésicos Locais/administração & dosagem , Humanos
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