[Free-radical and neuroimmune processes in primary and repeated craniocerebral trauma (in an experiment)]. / Svobodnoradikal'nye i neiroimmunnye protsessy pri pervichnoi i povtornoi cherepno-mozgovoi travme (v éksperimente).

The impact of primary and repeated brain injury (BI) (moderate contusion of the brain) on changes of pro- and antioxidative processes in the brain and blood, as well as on the body's neuroimmune responses during 30 days following injury were studied in an experiment on albino rats. The changes in the rate of lipid peroxidation (LPO) were shown to be significantly higher in repeated BI than in primary one. There was no correlation between the changes in the rate of LPO in the blood and in the brain tissue. Immune disorders, namely: the proliferative activity of T and B lymphocytes were slightly milder than in primary BI while in repeated BI, neurosensitization was detectable earlier, which was more pronounced. Thus, goal-oriented correction of free radical processes should be made in the brain and of neuroimmune disorders in BI.

[The characteristics of the immune disorders in primary and repeated craniocerebral trauma]. / Osoblyvosti imunnykh porushen' pry pervynnii ta povtornii cherepno-mozkovii travmi.

The immune shifts induced by initial and recurrent craniocerebral injuries were studied experimentally on white rats. It was found that in an initial injury the inhibition of cellular and humoral immunity occurred on the 1st posttraumatic day. In case of a recurrent injury taking place 30-40 days after an initial one, the alterations in cellular and humoral immunity were less pronounced. Autoimmune responses to the brain antigens were more intensive in a recurrent injury and could be revealed as soon as on the 1st posttraumatic day. It follows therefore that the results of this study evidence for the immune difference between initial and recurrent injuries.

[The level of embryonic antigens in the blood serum and cerebrospinal fluid of neuro-oncological patients]. / Soderzhanie émbrional'nykh antigenov v syvorotke krovi i likvore neiroonkologicheskikh bol'nykh.

The levels of embryonic antigens (cancer embryonic antigen, alpha-fetoprotein, beta-chorionic gonadotropin were measured in the serum, spinal fluid, the cystic fluid of tumor 83 of neuro-oncological patients. It was found that the blood concentrations of cancer embryonic antigen and alpha-fetoprotein were not generally related to the degree of malignancy and the blood level of beta-chorionic gonadotropin decreased with the higher degree of tumor anaplasia. The high content of beta-chorionic gonadotropin in the spinal fluid suggests its origin from a brain tumor. The fatal postoperative outcome was noted in patients having high preoperative serum levels of alpha-fetoprotein and cancer embryonic antigen with simultaneous much higher concentrations of alpha-fetoprotein in the serum than those in the spinal fluid.

[Clinico-diagnostic value of the immunologic parameters of blood and cerebrospinal fluid in patients with a tumor of the posterior cranial fossa]. / Kliniko-diagnosticheskoe znachenie immunologicheskikh pokazatelei krovi i spinnomozgovoi zhidkosti u bolnykh s opukholíu zadnei cherepnoi iamki.

In 37 patients with a tumor of the posterior cranial fossa, the immunologic indices of the spinal fluid, blood serum and tumor contents were studied. It was established that changes in the immunologic indices (intrathecal synthesis of IgG and IgA, production of the immunoregulatory factors of cellular immunity, severity of lesion of the brain structures) depended on a degree of tumor anaplasia and age of the patients. These findings can be used for diagnosis of cerebral neoplasms of different degree of malignancy with regard for the age of a patient.

[Changes in the immune status of patients with brain tumors in the pre- and postoperative periods]. / Izmeneniia immunnogo statusa u bol'nykh s opukholiami golovnogo mozga v do- i posleoperatsionnom periode.

Changes of the immune status in patients with glioblastomas and meningiomas during the stages of surgical treatment were studied. Functional activity of lymphocytes suffers to a greater measure in patients in the preoperative period and the ratio of the lymphocyte T- and B-subpopulations changes. Preoperative management including hormonal therapy causes further inhibition of the immune status but has no effect on the degree of neurosensitization of the patients, which may be a risk factor of the development of postoperative complications of infectious-inflammatory neuroallergic etiology. Immunogenesis remains inhibited in the early postoperative period, on the 2nd-3rd day after the operation. By the 7th-10th postoperative day significant restoration of the number and functional activity of lymphocytes is encountered in patients with meningiomas, while in patients with glioblastomas inhibition of lymphocyte proliferative activity persists.

[The use of myelopid in the combined treatment of infectious-inflammatory complications in the postoperative period in neuro-oncology patients]. / Primenenie mielopida v kompleksnom lechenii infektsionno-vospalitel'nykh oslozhnenii v posleoperatsionnom periode u neiroonkologicheskikh bol'nykh.

Clinical observations over 48 neurosurgical patients with infectious inflammatory complications and study of their immune status showed that a course of immunocorrective therapy with myelopid produces a favourable clinical effect and normalizes the patient's immune status. Myelopid causes the best normalizing effect in patients with nontumorous pathology of the central nervous system and in extracerebral neoplasms.

[Lymphocyte subpopulations and their functional activity in patients with brain tumors]. / Subpopuliatsii limfotsitov i ikh funktsional'naia aktivnost' u bol'nykh s opukholiami golovnogo mozga.

The authors studied a complex of immunological indices in 69 patients with brain tumours in the pre- and postoperative period. It is shown that in patients with benign brain tumours, preoperative care and surgical intervention largely alter the functional activity of T and B-lymphocytes while patients with malignant tumours of the brain revealed less pronounced changes of quantitative indices of definite subpopulations of lymphocytes against the background of marked reduction of their functional activity. The necessity is emphasized of complex evaluation of immunological indices in patients with brain tumours.

[The effect of surgical intervention on the state of the immune system in brain tumors]. / Vliianie khirurgicheskogo vmeshatel'stva na sostoianie sistemy immuniteta pri opukholiakh golovnogo mozga.

In patients with benign and malignant brain tumors before the operation, the suppression of the immune system, in particular, proliferative response of lymphocytes to T- and B-mitogens was established. Preoperative preparation of the patients aggravated this process. At day 8-10 after the operation, normalization of the main indices of immunity in patients with benign tumors was noted. In malignant tumors after the operation, the increase in the contents of T- and B-lymphocytes against the background of decrease in their proliferative activity was observed.

[Immunologic status of patients in the late period after cranio-cerebral trauma]. / Immunnyi status u bo'lnykh v otdalennom periode cherepno-mozgovoi travmy.

Immune disorders characteristic of the late period of craniocerebral trauma involve T-cellular, regulatory link and were represented by a reduction of T-cells count and function with disbalance in lymphocytes-helpers, increase in macrophagal and lymphoid suppressors activity susceptible to indomethacin++. The changes also include the neurosensibilization of cellular and humoral type to brain-specific++ proteins: OBM, 14-3-2, S-100. Most pronounced changes were detected in patients after severe brain concussion with focal neural changes persisting in the late period.