[DNA polymorphism in a Brazilian population: relationship to allele frequencies in France]. / Polymorphisme de l'ADN dans une population brésilienne: comparaison avec les fréquences alléliques en France.

The allele frequency distribution of two highly polymorphic DNA sequences was determined in a population from the metropolitan area of Fortaleza (Northeast Brazil). DNAs from 234 individuals were digested with Pvull and successively hybridized to each probe: alpha-Globin 3'HVR and Mucin HVR. The resulting allele frequencies were compared to those observed in a French population. There is no statistically significant difference between these populations in the 3'HVR system. On the contrary, the distribution is statistically different in the Mucin HVR/Pvull system.

[DNA polymorphism: comparison of allelic frequencies obtained with two HVR probes in a population from Northeastern Brazil and in two other ethnic groups]. / Polymorphisme de l'ADN: comparaison des fréquences alléliques obtenues avec deux sondes HVR dans une population du Nord-Est du Brésil et dans deux autres groupes ethniques.

DNAS from 325 individuals representing 2 different populations (234 Brazilians and 91 Asiatics) were analysed for Restriction Fragment Length Polymorphisms (RFLPs). These DNAs were digested with Pvu II enzyme and successively hybridized to two HVR probes: alpha globin-3'HVR and Mucin-HVR. An allele frequency distribution was determined for each couple probe/enzyme and each ethnic groupe studied. The results were compared with frequencies observed in french population and we showed that there is no statistic significant difference between allele frequencies obtained with the couple probe/enzyme 3'HVR/Pvu II in Brazilian and French populations. We also showed that both populations studied (Brazilian and Asiatic) do not follow a Hardy-Weinberg balance.