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Br J Haematol ; 196(1): 215-223, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34536019

RESUMO

Congenital platelet disorders (CPDs) are rare bleeding disorders that are associated with mucocutaneous bleeds. However, data on vaginal bleeding in women with CPDs are scarce. A set of generic and bleeding-specific questionnaires were used to evaluate the prevalence of vaginal bleeding, its impact on quality of life (QoL) and sexual functioning and the consequences for pregnancy, miscarriage and delivery in a cohort of women who were referred for diagnostic evaluation for CPDs. A total of 78 women included in the study were either diagnosed with a CPD (n = 35) or were clinically suspected of a CPD (n = 43). Heavy menstrual bleeding (HMB) was reported by a large proportion of women, which mainly started at menarche. In all, 76% of women received any kind of HMB treatment, often leading to surgical prodecures. HMB was shown to have a high impact on QoL, which improved upon treatment. Even though women reported that vaginal bleeding affects sexuality, this topic is not frequently discussed with physicians. Heavy blood loss frequently occurred after miscarriage/delivery, often requiring treatment. Women with (suspected) CPDs frequently encounter HMB, negatively impacting daily life and sexual functioning. Together with peripartum bleeding, these data highlight the burden of vaginal bleeding in CPDs and importance of adequate treatment.


Assuntos
Transtornos Plaquetários/complicações , Transtornos Plaquetários/epidemiologia , Hemorragia Uterina/epidemiologia , Hemorragia Uterina/etiologia , Adulto , Idade de Início , Transtornos Plaquetários/etiologia , Efeitos Psicossociais da Doença , Estudos Transversais , Gerenciamento Clínico , Suscetibilidade a Doenças , Feminino , Humanos , Menorragia , Pessoa de Meia-Idade , Países Baixos/epidemiologia , Prevalência , Vigilância em Saúde Pública , Qualidade de Vida , Inquéritos e Questionários , Resultado do Tratamento , Hemorragia Uterina/diagnóstico , Hemorragia Uterina/terapia
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