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ObjectiveTo evaluate the accuracy and value of the ultrasonography and magnetic resonance imaging (MRI) in the diagnosis of agenesis of the corpus callosum in the newborns.MethodsConventional cerebral ultrasound screening was performed in 8086 newborns admitted to NICU in our hospital from January 2012 to June 2014 and agenesis of the corpus callosum was suspected or conifrmed in 31 newborns. The diagnostic accuracy of ultrasonography was assessed through the com-parison between the results of ultrasonography and MRI.ResultsIn 31 cases with suspected agenesis of the corpus callosum, ultrasonography showed 14 cases of complete agenesis of which 13 cases had the same diagnosis with MRI except one case of partial agenesis, meanwhile, ultrasonography showed 16 cases of partial agenesis of which 15 cases had the same diagnosis with MRI except one case of complete agenesis. One case of abnormal corpus callosum determined by ultrasonography was diagnosed as partial agenesis by MRI. MRI showed there were other brain malformations in 14 cases.ConclusionsUltrasonography and MRI has a high consistency in the diagnosis of agenesis of the corpus callosum in neonates, so the former can be used as a routine screening and the latter can be used as a method of accurate diagnosis. A combination of both has an important role in early diag-nosis and clinical evaluation.
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Objective To investigate the relationship between the area of corpus callosum and neurodevelopmental outcomes in very preterm infants.Methods Brain magnetic resonance (MR) images of 106 term infants with gestational age 40 weeks were obtained,which were collected in 24h after birth.Brain MR images of 130 very low birth weight (VLBW) neonates at 40-week gestational age equivalent were successfully obtained.A total of 228 eligible MR images of them were chosen,and divided into the full-term infant group (100 cases) and the premature infant group (128 cases).The whole and sub-regional corpus callosum areas were calculated.The 20-neuromotor examinations were performed at 3 months of corrected gestational age.Results The whole corpus callosum,anterior mid-body,posterior mid-body,isthmus and splenium area in very premature infant group were significantly smaller than those in full-term infant group (P ＜ 0.05),but the differences in genu and rostral body area between two groups was not statistically significant (P ＞ 0.05).The genu area in the abnormal nervimotion group was significantly smaller than that in the normal nervimotion group (P ＜ 0.05),but the differences in the whole corpus callosum,anterior mid-body,posterior mid-body,isthmus,and spleniuvm area between two groups were not statistically significant (P ＞ 0.05).Conclusions The development of very premature infant corpus callosum is affected by prematurity,especially posterior end of corpus callosum.Adverse neurodevelopmental outcomes at 3 months of corrected gestational age may be associated with decreased genu area of corpus callosum in very preterm infants.
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The appearance of corpus callosum in the term neonates is different from that of the infant and adults,and it is also different between the term neonates and the preterm infants. With the development of medical imaging techniques,the detection of neonatal callosal development has become more sophisticated and clinicians have a new understanding of the evaluation of brain development. The review summarizes the evalua-tion of neonatal corpus callosum utilizing ultrasonography,computed tomography and magnetic resonance ima-ging.
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The basic pain threshold and pain tolerance were measured by use of radiant heat stimulation in healthy volunteers, which were close to normal distribution. The stability was obtained by repeated determination for same individuals in different time. With this method, a clinical assessment of analgesic drugs was carried out among healthy volunteers. Acetaminophen-Codeine tablet ( 2 tablets ) was able to depress pain response by increasing pain threshold and tolerance of 23% and 12% ( P
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Buprenorphine, a synthetic derivative of Thebaine, is a strong new analgesic agent. It was compared with pethidine in doudle-blind trial of 86 burn and plastic patients with severe or moderate pain. The result showed that the analgesic effect of Buprenorphine 0.3 mg I. M. appeared superior to Pethidine 50mg ( P
