Therapeutic Observation of Modified Blistering Moxibustion for Bronchial Asthma in Young Adults / 上海针灸杂志

Objective To observe the therapeutic difference between modified blistering moxibustion and traditional blistering moxibustion in treating bronchial asthma in young adults.Method Totally 121 young adults with bronchial asthma were randomized into a treatment group of 62 cases and a control group of 59 cases. With the same points selected for the two groups, the treatment group was intervened by blistering moxibustion with modification in several aspects including columnar moxa cone, topical anesthesia in moxibustion region, application of sticking after moxibustion, and regulation of diet, while the control group was by traditional blistering moxibustion. The treatment was given once every summer, successive 3 times as a treatment course. The attack frequency and intensity were scored before intervention and after a treatment course, and the clinical efficacies were compared between the two groups.Result The attack frequency and intensity scores were significantly changed after the intervention in both groups (P0.05). There were significant differences in comparing the blister parameters (blister starting time, blister scar falling-off time, pus drainage time, recovery time of the blister, and the maximum diameter of the blister) between the two groups (P<0.01,P<0.05).Conclusion Modified blistering moxibustion is an effective method in treating bronchial asthma in young adults.

Effects of chicken intestinal antimicrobial peptides on humoral immunity of chickens and antibody titres after vaccination with infectious bursal disease virus vaccine in chicken.

Sixty chickens were randomly divided into two groups (30 chickens in each group) to determine the effect of oral administration of chicken intestinal antimicrobial peptides (CIAMP) on the humoral immune response. Chickens of both groups were fed the same diet. In the treatment group chickens received drinking water supplemented with CIAMP (1 microg/ml) right after hatching. Samples of blood, bursa of Fabricus, spleen and intestine were taken at day 1, 4, 7, 10 and 17 of experiment. CIAMP supplementation enhanced the content of IgG and IgM in serum from day 4-10 and day 10-17, respectively, (p < 0.05), IgM-forming cells in bursa of Fabricus and spleen at the age of 7 days (p < 0.05) and IgG-forming cells in bursa of Fabricus at the age of 4 days (p < 0.05). In addition, CIAMP enhanced the IgA-forming cells in caecal tonsils diffuse area at day 4 (p < 0.05). Furthermore, CIAMP enhanced the antibody response to infectious bursal disease virus vaccine (IBDV) in chickens 21 days following IBDV vaccine administration (p < 0.05). These results suggested that CIAMP could modulate the humoral immune response of chickens and increased the antibody titres of infectious bursal disease virus vaccine.

Effect of probiotics on intestinal mucosal immunity and ultrastructure of cecal tonsils of chickens.

Sixty chickens were randomly divided into two groups to determine the effect of oral administration of probiotics on the intestinal mucosal immune response and ultrastructure of cecal tonsils. The first group (control) was fed with a basic diet without antibiotic or probiotics. The second group was fed with the same diet as the control, except they received drinking water with probiotics (4 x 10(9) cfu per chicken and day) from posthatch to day 3 of age. The probiotic preparation was composed of Bacillus subtilis Bs964, Candida utilis BKM-Y74 and Lactobacillus acidophilus LH1F. Intestinal fluid, Peyer's Patch and cecal tonsils were taken at day 1, 4, 7, 10 and 18 after administration of probiotics. The results showed: (i) Compared to the control, probiotics enhanced the content of following items: immunglobulin (Ig)A in the intestinal fluid at day 7 (p < 0.01), the IgG-forming cells at day 10 (p < 0.05), IgM-forming cells in the Peyer's Patch at day 7 (p < 0.05), IgA-forming cells at day 7-10 (p < 0.05), IgG-forming cells at day 7 (p < 0.05) and IgM-forming cells in cecal tonsils diffuse area at day 4-7 (p < 0.05). (ii) T lymphocytes in cecal tonsils were enhanced at day 7 (p < 0.01) after orally fed with probiotics. (iii) The density of microvilli and length of cecal tonsils increased after probiotics were administrated at day 3. With chicken ageing, the efficiency of probiotics would decrease. These results suggested that probiotics enhance intestinal mucosal immunity of chicken at the early age.

Observation on Therapeutic Effect of Cold Moxibustion on Rheumatoid Interphalangeal Arthritis / 针灸推拿医学（英文版）

Purpose: To observe the clinical therapeutic effect of cold moxibustion on rheumatoid interphalangeal arthritis. Methods: 576 cases were randomly divided into 290 cases in the cold moxibustion group and 286 cases in the control group and were treated for two months. Results:There was no significant difference in the total effective rate between the two groups. But, at the end of the second course of the treatment, the complete remission rate reached 77.2% in the former group and only 23.4% in the latter group, with a significant difference between the two groups (P＜0.005).Conclusion: Cold moxibustion is better in the therapeutic effect for rheumatoid interphalangeal arthritis than anti-inflammatory agents of western medicine.

CHANGES ON EXPRESSION OF bcl-2,p53 AND CADHERIN IN ADULT HAMSTER SPERMATOGENIC CELLS DURING DES INDUCING ABNORMAL SPERMATOGENESIS / 解剖学报

Objective To prove the mechanism of diethylstibestrol(DES) induced abnormal spermatogenesis,this study on the changes of proto-oncogenes bcl-2 and p53 proteins as well as cadherin adherens molecules expression in adult male hamster spermatogenic cells. Methods Adult male golden hamsters were treated daily olive oil vehicle either alone(control)or containing 1 mg/kg body weight of DES (experiment)by subcutaneous injection for 7 days.The changes of testes histological morphology were observed under light and electron microscope.The expressions of bcl-2 and p53 and cadherin in the testes seminiferous epithelium were detected by immunohistochemistry. Results DES induced adult hamster testes abnormal spermatogenesis.As compared to the control group animals,in DES-treated group animals the expression of both bcl-2 and p53 significantly increased in spermatogenic cells,especially in spermatocytes and round spermatids.However,the expression of cadherin adherens molecules obviously decreased.Conclusion It is one of reasons of DES inducing abnormal spermatogenesis that DES can result in increasing in the expression of proto-oncogenes bcl-2 and p53,and reducing cadherin adherens molecules expression.