Incidencia y mortalidad por infarto agudo de miocardio en la población mayor de 60 años del área de Tarragona / Incidence and mortality of ischaemic stroke among people 60 years or older in the región of Tarragona, Spain

Fundamentos. La información procedente de datos de base poblacional sobre la epidemiología del infarto agudo de miocardio es limitada. Este estudio analizó la incidencia y mortalidad por infarto en la población general mayor de 60 años del área sanitaria de Tarragona. Métodos. Estudio de cohortes que incluyó a 27.204 personas ≥60 años adscritas a 9 Áreas Básicas de Salud en la comarca del Tarragonés. Se realizó un seguimiento prospectivo durante 3 años, en los que se registraron todos los episodios de infarto diagnosticados entre los miembros de la cohorte desde 01/12/2008 a 30/11/2011. Se incluyeron exclusivamente los episodios con diagnóstico validado tras revisión de la historia clínica, se excluyeron los casos sin confirmación electrocardiográfica y por biomarcadores. Resultados: Hubo un total de 359 episodios confirmados de infarto, lo cual supuso una incidencia de 475 episodios por 100.000 personas-año (IC 95%: 428-527). La incidencia en hombres fue de 681 por 100.000 y en mujeres de 311 (p<0,001). Por edad fue 277 en el grupo de 60-69, 632 en el de 70-79 y 690 por 100.000 en los sujetos de ≥80 años (p<0,001). La incidencia en las personas con diagnóstico previo de cardiopatía isquémica fue de 2.844 casos por 100.000 personas-año. La mortalidad a los 30 días tras el diagnóstico alcanzó el 15,3%, en hombres 14,9% y en mujeres 16,0% (p=0,776). Conclusiones: La incidencia fue 2,2 veces mayor en hombres que en mujeres y aumentó considerablemente con la edad. También fue superior entre las personas con diagnóstico previo de cardiopatía isquémica. La mortalidad fue ligeramente más baja en hombres que en mujeres (AU)

Background: Population-based data available about the epidemiology of acute myocardial infarction is limited. This study investigated incidence and mortality from infarction among the general population over 60 years in Tarragona. Methods: Cohort study that included 27,204 individuals ≥60 years assigned to nine Primary Care Centers in the Tarragones county (Catalonia, Spain), who were prospectively followed between 01/12/2008 and 30/11/2011. During follow-up, all presumptive episodes of infarction were recruited among cohort members, but only confirmed cases (electrocardiogram and biomarkers confirmation) were included. Results: There were an amount of 359 confirmed episodes of infarction, which means a global incidence rate of 475 episodes per 100,000 person-years (95% CI: 428-527). Incidence was 681 in men and 311in women (p<0.001). According to age, incidence was 277 in 60-69, 632 in 70-79 and 690 per 100,000 in ≥80 years (p<0.001). Incidence was 2,844 cases per 100,000 person-years among those persons whom had history of prior coronary artery disease. Overall 30-day mortality rate was 15.3%, in male 14.9% and in female 16.0% (p=0.776). Conclusion: Incidence was 2.2 times higher in men than in woman and increased considerable by age. It was greater among patients with prior history of coronary artery disease. Mortality was slightly lower in men than in women (AU)

[Incidence and mortality of ischaemic stroke among people 60 years or older in the region of Tarragona, Spain]. / Incidencia y mortalidad por infarto agudo de miocardio en la población mayor de 60 años del área de Tarragona.

BACKGROUND: Population-based data available about the epidemiology of acute myocardial infarction is limited. This study investigated incidence and mortality from infarction among the general population over 60 years in Tarragona. METHODS: Cohort study that included 27,204 individuals ≥60 years assigned to nine Primary Care Centers in the Tarragones county (Catalonia, Spain), who were prospectively followed between 01/12/2008 and 30/11/2011. During follow-up, all presumptive episodes of infarction were recruited among cohort members, but only confirmed cases (electrocardiogram and biomarkers confirmation) were included. RESULTS: There were an amount of 359 confirmed episodes of infarction, which means a global incidence rate of 475 episodes per 100,000 person-years (95% CI: 428-527). Incidence was 681 in men and 311in women (p<0.001). According to age, incidence was 277 in 60-69, 632 in 70-79 and 690 per 100,000 in ≥80 years (p<0.001). Incidence was 2,844 cases per 100,000 person-years among those persons whom had history of prior coronary artery disease. Overall 30-day mortality rate was 15.3%, in male 14.9% and in female 16.0% (p=0.776). CONCLUSION: Incidence was 2.2 times higher in men than in woman and increased considerable by age. It was greater among patients with prior history of coronary artery disease. Mortality was slightly lower in men than in women.

Role of the yeast multidrug transporter Qdr2 in cation homeostasis and the oxidative stress response.

We have identified QDR2 in a screening for genes able to confer tolerance to sodium and/or lithium stress upon overexpression. Qdr2 is a multidrug transporter of the major facilitator superfamily, originally described for its ability to transport the antimalarial drug quinidine and the herbicide barban. To identify its physiological substrate, we have screened for phenotypes dependent on QDR2 and found that Qdr2 is able to transport monovalent and divalent cations with poor selectivity, as shown by growth tests and the determination of internal cation content. Moreover, strains overexpressing or lacking QDR2 also exhibit phenotypes when reactive oxygen species- producing agents, such as hydrogen peroxide or menadione were added to the growth medium. We have also found that the presence of copper and hydrogen peroxide repress the expression of QDR2. In addition, the copper uptake of a qdr2 mutant strain is similar to a wild type, but the extrusion is clearly impaired. Based on our results, we propose that free divalent copper is the main physiological substrate of Qdr2. As copper is a substrate for several redox reactions that occur within the cytoplasm, its function in copper homeostasis explains its role in the oxidative stress response.