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1.
Artigo em Russo | MEDLINE | ID: mdl-21350415

RESUMO

The brain blood flow autoregulation (BFA) has been studied in normalcy and different variants of atherosclerosis in 97 subjects. Group 1 included 32 patients with obliterating atherosclerosis of the arteries of the low extremities with different stages of chronic artery insufficiency without hemodynamic lesions of brachiocephalic arteries; group 2 consisted of 30 patients wit different forms of chronic brain ischemia with hemodynamically significant unilateral atherosclerotic stenosis of the inner carotid artery (from 70 to 95%). The control group included 35 healthy volunteers aged 20-25 years. BFA parameters were assessed using the original technique worked out by the authors. In the normalcy, the BFA mechanism is able to maintain the constancy of perfusion pressure in the brain due to two major components. In the first stage, it is the aggravation of arterial blood inflow lasting for 1,5 min after the removal of pneumatic cuffs with the following surpassing increase of the venous blood outflow from the scull that decreases the tissue pressure. The most distinct BFA changes were seen in patients with hemodynamically significant stenosis of the inner carotid artery while patients with peripheral atherosclerosis had less marked BFA disturbances.


Assuntos
Aterosclerose/fisiopatologia , Encéfalo/irrigação sanguínea , Circulação Cerebrovascular , Hemodinâmica , Homeostase , Idoso , Aterosclerose/diagnóstico por imagem , Isquemia Encefálica/diagnóstico por imagem , Isquemia Encefálica/fisiopatologia , Estenose das Carótidas/diagnóstico por imagem , Estenose das Carótidas/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Doença Arterial Periférica/diagnóstico por imagem , Doença Arterial Periférica/fisiopatologia , Ultrassonografia
3.
Angiol Sosud Khir ; 16(4): 47-51, 2010.
Artigo em Russo | MEDLINE | ID: mdl-21389945

RESUMO

The authors have hereby proposed a method to diagnose lower-limb muscular ischaemia by means of scintigraphy, used in 35 patients suffering from atherosclerosis obliterans with stage IIB and III A chronic arterial insufficiency of limbs. To do so, administration of the radioactive agent "Myoview" (99m)Tc-tetrophosmine) manufactured by the "Nycomed" Company into a patient's peripheral vein was followed by assessing its accumulation in lower-limb muscles at rest and after standard physical load. Alterations in the parameters studied relative to the norm made it possible to judge on the presence of lower-limb circulatory impairments. The method proved highly efficient, thus making it possible to use it for both therapeutic decision-making and probably in future for dynamic control after the treatment performed. Minimally invasive nature and simplicity in use of the methodology open wide possibilities for its use.


Assuntos
Arteriosclerose Obliterante/diagnóstico por imagem , Imagem de Perfusão/métodos , Fluxo Sanguíneo Regional/fisiologia , Adulto , Arteriosclerose Obliterante/fisiopatologia , Diagnóstico Diferencial , Humanos , Injeções Intra-Arteriais , Masculino , Pessoa de Meia-Idade , Compostos Organofosforados/administração & dosagem , Compostos de Organotecnécio/administração & dosagem , Compostos Radiofarmacêuticos/administração & dosagem , Reprodutibilidade dos Testes , Índice de Gravidade de Doença
4.
Eksp Klin Farmakol ; 71(5): 48-51, 2008.
Artigo em Russo | MEDLINE | ID: mdl-19093373

RESUMO

Data on the therapeutic effectiveness of intravenous injections of immunoglobulins in high doses in patients with bronchial asthma are analyzed. Some possible mechanisms of this therapeutic effect are considered, which are related to of immunoglobulin fragments capable of interacting with cytochrome P-450 and NO-synthase systems of the liver.


Assuntos
Asma/tratamento farmacológico , Sistema Enzimático do Citocromo P-450/metabolismo , Imunoglobulinas/uso terapêutico , Fígado/enzimologia , Óxido Nítrico Sintase/metabolismo , Asma/enzimologia , Humanos
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