Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Clin Perinatol ; 47(3): 593-615, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32713453

RESUMO

Neonatal pulmonary hypertension is a heterogeneous disease in term and preterm neonates. It is characterized by persistent increase of pulmonary artery pressures after birth (acute) or an increase in pulmonary artery pressures after approximately 4 weeks of age (chronic); both phenotypes result in exposure of the right ventricle to sustained high afterload. In-depth clinical assessment plus echocardiographic measures evaluating pulmonary blood flow, pulmonary vascular resistance, pulmonary capillary wedge pressure, and myocardial contractility are needed to determine the cause and provide individualized targeted therapies. This article summarizes the causes, risk factors, hemodynamic assessment, and management of neonatal pulmonary hypertension.


Assuntos
Hipertensão Pulmonar/terapia , Circulação Pulmonar/fisiologia , Veias Pulmonares/fisiopatologia , Disfunção Ventricular Direita/fisiopatologia , Doença Aguda , Cateterismo Cardíaco , Doença Crônica , Ecocardiografia , Humanos , Hipertensão Pulmonar/diagnóstico , Hipertensão Pulmonar/fisiopatologia , Recém-Nascido , Recém-Nascido Prematuro , Imageamento por Ressonância Magnética , Síndrome da Persistência do Padrão de Circulação Fetal/diagnóstico , Síndrome da Persistência do Padrão de Circulação Fetal/fisiopatologia , Síndrome da Persistência do Padrão de Circulação Fetal/terapia , Fenótipo , Síndrome do Desconforto Respiratório do Recém-Nascido/fisiopatologia , Tomografia Computadorizada por Raios X , Resistência Vascular , Disfunção Ventricular Direita/diagnóstico
2.
Am J Reprod Immunol ; 79(5): e12800, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29243317

RESUMO

Over the last few years, scientific interest in the cytokine IL-17A has intensified as its role in human health and disease has been elucidated. Discovered almost a quarter century ago, IL-17A is known to have poor biologic activity when acting alone, but attains robust actions when working synergistically with potent mediators of proinflammatory immune responses, such as IL-6 and IL-8. IL-17A is produced by specialized innate immune cells that protect host barriers from the outside world. Like sentries, these innate immune cells can "sound the alarm" through increased production of IL-17A, causing activation and recruitment of primed neutrophils and monocytes when pathogens escape initial host defenses. In this way, IL-17A promulgates mechanisms responsible for pathogen death and clearance. However, when IL-17A pathways are triggered during fetal development, due to chorioamnionitis or in utero inflammatory conditions, IL-17A can instigate and/or exacerbate fetal inflammatory responses that increase neonatal morbidities and mortality associated with common neonatal conditions such as sepsis, bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), and necrotizing enterocolitis (NEC). This review details the ontogeny of IL-17A in the fetus and newborn, discusses how derangements in its production can lead to pathology, and describes known and evolving therapies that may attenuate IL-17A-mediated human conditions.


Assuntos
Doenças do Recém-Nascido/imunologia , Interleucina-17/imunologia , Animais , Humanos , Imunidade Inata/imunologia , Saúde do Lactente , Recém-Nascido , Inflamação/imunologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...