RESUMO
Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the United States population. This guideline addresses important clinical questions that arise in psoriasis management and care and provides recommendations based on the available evidence. The treatment of psoriasis with topical agents and with alternative medicine will be reviewed, emphasizing treatment recommendations and the role of dermatologists in monitoring and educating patients regarding benefits as well as risks that may be associated. This guideline will also address the severity assessment methods of psoriasis in adults.
Assuntos
Terapias Complementares/métodos , Fármacos Dermatológicos/administração & dosagem , Dermatologia/métodos , Psoríase/terapia , Academias e Institutos/normas , Administração Cutânea , Terapia Combinada/métodos , Terapia Combinada/normas , Terapias Complementares/normas , Dermatologia/normas , Medicina Baseada em Evidências/métodos , Medicina Baseada em Evidências/normas , Fundações/normas , Humanos , Educação de Pacientes como Assunto/normas , Psoríase/diagnóstico , Índice de Gravidade de Doença , Resultado do Tratamento , Estados UnidosRESUMO
Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 2% of the world's population. In this guideline, we focus the discussion on systemic, nonbiologic medications for the treatment of this disease. We provide detailed discussion of efficacy and safety for the most commonly used medications, including methotrexate, cyclosporine, and acitretin, and provide recommendations to assist prescribers in initiating and managing patients on these treatments. Additionally, we discuss newer therapies, including tofacitinib and apremilast, and briefly touch on a number of other medications, including fumaric acid esters (used outside the United States) and therapies that are no longer widely used for the treatment of psoriasis (ie, hydroxyurea, leflunomide, mycophenolate mofetil, thioguanine, and tacrolimus).
Assuntos
Psoríase/tratamento farmacológico , Acitretina/uso terapêutico , Ciclosporina/uso terapêutico , Monitoramento de Medicamentos , Humanos , Metotrexato/uso terapêutico , Piperidinas/uso terapêutico , Pirimidinas/uso terapêutico , Talidomida/análogos & derivados , Talidomida/uso terapêuticoRESUMO
Psoriasis is a chronic, multisystem, inflammatory disease that affects approximately 1% of children, with onset most common during adolescence. This guideline addresses important clinical questions that arise in psoriasis management and provides evidence-based recommendations. Attention will be given to pediatric patients with psoriasis, recognizing the unique physiology, pharmacokinetics, and patient-parent-provider interactions of patients younger than 18 years old. The topics reviewed here mirror those discussed in the adult guideline sections, excluding those topics that are irrelevant to, or lack sufficient information for, pediatric patients.
Assuntos
Produtos Biológicos/uso terapêutico , Fármacos Dermatológicos/uso terapêutico , Metotrexato/uso terapêutico , Fotoquimioterapia , Psoríase/tratamento farmacológico , Psoríase/epidemiologia , Adolescente , Corticosteroides/uso terapêutico , Antralina/uso terapêutico , Inibidores de Calcineurina/uso terapêutico , Doenças Cardiovasculares/epidemiologia , Criança , Pré-Escolar , Alcatrão/uso terapêutico , Comorbidade , Ciclosporina/uso terapêutico , Dislipidemias/epidemiologia , Medicina Baseada em Evidências , Humanos , Lactente , Recém-Nascido , Doenças Inflamatórias Intestinais/epidemiologia , Resistência à Insulina , Saúde Mental , Síndrome Metabólica/epidemiologia , Ácidos Nicotínicos/uso terapêutico , Obesidade/epidemiologia , Psoríase/psicologia , Retinoides/uso terapêuticoRESUMO
Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 3.2% of the world's population. In this section of the guidelines of care for psoriasis, we will focus the discussion on ultraviolet (UV) light-based therapies, which include narrowband and broadband UVB, UVA in conjunction with photosensitizing agents, targeted UVB treatments such as with an excimer laser, and several other modalities and variations of these core phototherapies, including newer applications of pulsed dye lasers, intense pulse light, and light-emitting electrodes. We will provide an in-depth, evidence-based discussion of efficacy and safety for each treatment modality and provide recommendations and guidance for the use of these therapies alone or in conjunction with other topical and/or systemic psoriasis treatments.
Assuntos
Dermatologia/normas , Fototerapia/normas , Guias de Prática Clínica como Assunto , Psoríase/terapia , Academias e Institutos/normas , Fundações/normas , Humanos , Metanálise como Assunto , Fototerapia/instrumentação , Fototerapia/métodos , Revisões Sistemáticas como Assunto , Resultado do Tratamento , Estados UnidosRESUMO
Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations on the basis of available evidence.
Assuntos
Doenças Cardiovasculares/epidemiologia , Saúde Mental , Síndrome Metabólica/epidemiologia , Obesidade/epidemiologia , Papel do Médico , Psoríase/epidemiologia , Psoríase/psicologia , Qualidade de Vida , Artrite Psoriásica/diagnóstico , Artrite Psoriásica/epidemiologia , Comorbidade , Dislipidemias/epidemiologia , Medicina Baseada em Evidências , Humanos , Hipertensão/epidemiologia , Doenças Inflamatórias Intestinais/epidemiologia , Nefropatias/epidemiologia , Estilo de Vida , Hepatopatias/epidemiologia , Pneumopatias Obstrutivas/epidemiologia , Neoplasias/epidemiologia , Educação de Pacientes como Assunto , Psoríase/terapia , Síndromes da Apneia do Sono/epidemiologiaRESUMO
Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations based on the available evidence. The treatment of psoriasis with biologic agents will be reviewed, emphasizing treatment recommendations and the role of the dermatologist in monitoring and educating patients regarding benefits as well as associated risks.
Assuntos
Produtos Biológicos/uso terapêutico , Fármacos Dermatológicos/uso terapêutico , Psoríase/tratamento farmacológico , Adalimumab/uso terapêutico , Anticorpos Monoclonais/uso terapêutico , Anticorpos Monoclonais Humanizados , Medicamentos Biossimilares/uso terapêutico , Certolizumab Pegol/uso terapêutico , Quimioterapia Combinada , Etanercepte/uso terapêutico , Medicina Baseada em Evidências , Humanos , Infliximab/uso terapêutico , Piperidinas/uso terapêutico , Pirimidinas/uso terapêutico , Pirróis/uso terapêutico , Ustekinumab/uso terapêuticoRESUMO
Traditional medicine uses cultural knowledge and practices to promote health maintenance as well as diagnose and treat disease. In developing countries, the majority of people rely on traditional medicines; however, many of these practices have not been rigorously and systematically studied or reported. We review the current understanding and research behind traditional therapies prevalent in the Indian subcontinent, including mind-body and energy-based healing, botanical medicine, and herbal remedies. Topics covered include Ayurveda, yoga, naturopathy, Unani, Siddha, Sowa-Rigpa, homeopathy, and medicinal plants such as neem, guggul, tulsi, amla, and turmeric.
Assuntos
Etnobotânica , Fitoterapia , Preparações de Plantas/uso terapêutico , Dermatopatias/tratamento farmacológico , Azadirachta , Curcuma , Humanos , Índia , Medicina Tradicional , Ocimum sanctum , Phyllanthus emblicaRESUMO
INTRODUCTION: Nail psoriasis is challenging to treat. The few currently available therapies are limited in efficacy, and often produce unfavorable side effects. A plant extract widely used in Traditional Chinese Medicine, indigo naturalis (Qing Dai), is presented in this review as an alternative topical treatment for skin and nail psoriasis. The purpose of this article is to present information on a viable alternative treatment with a favorable side effect profile for a difficult disease to treat. METHODS: A PubMed search for the term "indigo naturalis" was performed, and literature from 2006 to the present relevant to indigo naturalis and treatment of psoriasis and nail psoriasis was reviewed. RESULTS: Indigo naturalis shares several therapeutic mechanisms with current psoriasis treatments, such as regulation of keratinocyte proliferation and differentiation, restoration of epidermal barrier function, and reduction of inflammatory processes. Clinically, it is well tolerated. CONCLUSION: Recent research of indigo naturalis suggests that it is a safe, inexpensive, and effective alternative topical treatment for skin and nail psoriasis.
Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Doenças da Unha/tratamento farmacológico , Fitoterapia/métodos , Psoríase/tratamento farmacológico , Administração Tópica , Proliferação de Células/efeitos dos fármacos , Citocinas/efeitos dos fármacos , Citocinas/metabolismo , Medicamentos de Ervas Chinesas/efeitos adversos , Medicamentos de Ervas Chinesas/economia , Epiderme/efeitos dos fármacos , Humanos , Indigofera , Indóis/efeitos adversos , Indóis/uso terapêutico , Queratinócitos/efeitos dos fármacos , Óleos/efeitos adversos , Óleos/uso terapêutico , Pomadas/efeitos adversos , Pomadas/uso terapêutico , Fitoterapia/efeitos adversos , Fitoterapia/economia , Ensaios Clínicos Controlados Aleatórios como Assunto , Índice de Gravidade de Doença , Transdução de Sinais/efeitos dos fármacos , Pele/efeitos dos fármacos , Resultado do Tratamento , Molécula 1 de Adesão de Célula Vascular/efeitos dos fármacos , Molécula 1 de Adesão de Célula Vascular/metabolismoRESUMO
A needle-free system that delivers lidocaine to the dermis using pressurized gas is often used as an alternative anesthetic for venipuncture and intravenous catheterization in children. This case report illustrates the potential histologic artifacts that may arise when using a needleless device for a cutaneous punch biopsy. We suggest against using a needleless system for pediatric skin biopsies.
Assuntos
Anestesia Local/efeitos adversos , Anestesia Local/instrumentação , Artefatos , Lidocaína/administração & dosagem , Neutropenia/patologia , Anormalidades da Pele/patologia , Anestésicos Locais/administração & dosagem , Biópsia/métodos , Criança , Feminino , HumanosRESUMO
Fusion hybrids between normal macrophages and Cloudman S91 melanoma cells were shown earlier to have increased metastatic potential, along with high expression of beta1,6-N-acetylglucosaminyltransferase V and beta1,6-branched oligosaccharides. Curiously, hybrids, but not parental melanoma cells, also produced 'coarse melanin'- autophagic vesicles with multiple melanosomes. As beta1,6-branched oligosaccharides were known to be associated with metastasis, and coarse melanin had been described in invasive human melanomas, we looked for potential relationships between the two. Using lectin- and immunohistochemistry, we analyzed cell lines producing coarse melanin for beta1,6-branched oligosaccharides: gp100/pmel-17 (a melanosomal structural component) and CD63 (a late endosome/lysosome component associated with melanoma and certain other human cancers). Cell lines used in this study were (i) hybrid 94-H48, a highly metastatic, macrophage-melanoma experimental fusion hybrid; (ii) 6(neo) mouse melanoma cells, the weakly metastatic, parental fusion partner; and (iii) SKmel-23, a human melanoma cell line derived from a metastasis. Coarse melanin granules were prominent both in hybrids and in SKmel-23 cells, and co-localized with stains for beta1,6-branched oligosaccharides, gp100/pmel 17, and CD63. This is the first report of this phenotype being expressed in vitro, although co-expression of beta1,6-branched oligosaccharides and coarse melanin was recently shown to be a common and pervasive characteristic in archival specimens of human melanomas, and was most prominent in metastases. The results suggest that pathways of melanogenesis in melanoma may differ significantly from those in normal melanocytes. In vitro expression of this phenotype provides new biological systems for more detailed analyses of its genesis and regulation at the molecular genetic level.