Laparoscopic Roux-en-Y gastric bypass surgery: initial results of 120 consecutive patients at a single British Columbia surgical center.

BACKGROUND: The prevalence of obesity in Canada is increasing, therefore, it has become imminently important to treat these patients in a timely manner. METHODS: A total of 120 consecutive patients who underwent a laparoscopic Roux-en-Y gastric bypass procedure (2004 to 2006), with a mean postoperative follow-up period of 19 months, were divided into 2 chronologic groups and analyzed retrospectively. RESULTS: The overall postoperative excess weight loss was 78.1% (SD, 14.3%) from the time of inclusion into the study preoperatively (average wait time, 21 mo) to 12 months postoperatively. No preoperative weight loss was recorded. A surgeon-dependent learning curve was shown with a decrease in surgical time as well as surgery-related complications. Obesity-associated comorbidities decreased whereas quality of life increased. CONCLUSIONS: Despite a structured multidisciplinary approach to alter lifestyle and daily caloric intake preoperatively, only laparoscopic Roux-en-Y gastric bypass showed effective weight loss and reduced associated comorbidities.

The surgical management of rectal cancer: a comparison of treatment methods and outcomes over 2 time periods in the same geographic region.

BACKGROUND: Preoperative radiotherapy combined with total mesorectal excision (TME) has provided excellent local control in the treatment of rectal cancer. This study is a review of patients treated at our regional cancer center from 1998 to 2004. The results were compared with a similar study carried out in our region from 1988 to 1998 to determine any changes in treatment methods, recurrence rates, and survival. METHODS: A retrospective review of 448 patients treated with definitive surgery for rectal cancer was conducted. Patient factors analyzed included sex, age, type of surgery, and adjuvant strategy. Tumor factors analyzed included level, stage, and grade. The presence of local recurrence was recorded and overall survival was determined. RESULTS: The local recurrence rate was 8.3% compared with 12.7% in the previous study. Patients treated with preoperative radiotherapy had a recurrence rate of 3.7%. The type of surgical therapy had no significant effect on local recurrence. There was no significant change in overall survival between the present study and the previous one. CONCLUSION: Preoperative radiotherapy is used more frequently in our region and has resulted in a decrease in the local recurrence rate compared to our previous retrospective review. There was no change in local recurrence seen in those patients treated with operative management alone. This study supports the use of preoperative radiotherapy in the management of rectal cancer.

Practice patterns of lymph-node mapping and sentinel-node biopsy for breast cancer in British Columbia.

INTRODUCTION: Because there is no standardized technique for mapping of lymph nodes and no optimal technique for evaluating the sentinel node, we decided to evaluate practice patterns for sentinel-node biopsy (SNB) for breast cancer in British Columbia 5 years after its introduction in 1996. METHODS: We carried out mail and telephone surveys of general surgeons performing at least 1 SNB (n = 28) or not performing SNB (n = 50), and carried out telephone surveys or on-site visits with pathologists (n = 7) and nuclear medicine physicians (n = 5) from institutions supporting SNB in the province. We collected data on training, perceived indications and techniques for the surgical, imaging and pathologic assessments of SNB to obtain data on practice patterns in 2001 and the degree of consistency among surgeons and institutions involved in performing SNB and reasons for not adopting the SNB technique. RESULTS: By 2001, SNB was incorporated into the practice of 19% of surgeons (28 of 150) performing breast cancer surgery in British Columbia. The survey response rate among SNB surgeons was 89% (25 of 28). Twelve (48%) of the 25 surgeons implemented SNB in the context of a validation study. Ten (40%) of the 25 had no data management support to monitor their results. Surgical training included intraoperative mentoring alone (48%), formal training courses alone (20%), both (24%) and self-teaching (8%). One-third of the surgeons had performed fewer than 10 procedures. Five surgeons had abandoned routine axillary dissection. There was considerable variation regarding the indications for SNB, definition of a sentinel node and surgical techniques. All nuclear medicine departments had a written lymphatic mapping protocol, but each used a different volume and activity of radiotracer. Immunohistochemical evaluation of the sentinel nodes was performed at just 3 pathology laboratories. The survey response rate from surgeons not practising SNB was 54% (27 of 50). Among 24 responders in active practice, 7 (29%) planned to perform SNB; 79% had not decided on the SNB indications. Lack of operating room time was a major limiting factor. CONCLUSIONS: There was considerable variation in the surgical, nuclear medicine and pathology techniques for SNB in the absence of a planned approach for its implementation in British Columbia. Developing consensus around written guidelines for the indications and techniques of SNB may reduce this variation.

Outcomes of sentinel node biopsy for breast cancer in British Columbia, 1996 to 2001.

BACKGROUND: This study evaluated the outcomes of the first 5 years of sentinel node biopsy (SNB) in British Columbia (BC), Canada, 1996 to 2001. METHODS: There were 547 SNB procedures for breast cancer performed by 29 surgeons at 12 hospitals in BC between October 1996 and July 2001. Identification, accuracy, and false-negative rates were determined and correlated to patient, tumor, and surgical factors with the chi-square test. RESULTS: SNB mapping was performed using blue dye alone (15%), radiopharmaceutical alone (6%), or both (79%). A completion axillary dissection was performed in 93%. A median of 2 (range 1 to 16) sentinel nodes was biopsied. The overall identification rate was 88%, accuracy was 92%, and false-negative rate was 22%. All rates were improved in younger (age <50 years) compared with older women. A positive lymphoscintiscan and the mapping agent used were associated with higher identification rates but not accuracy or false negative rates. Increasing surgeon experience was not significantly associated with improvements in identification or false-negative rates. CONCLUSIONS: The potential of SNB was not fully translated into surgical practice in BC by 2001.