RESUMO
ABSTRACT Introduction: Colorectal cancer has the second highest prevalence and the third highest incidence in the world. Mortality is directly related to the stage of the disease. Objective: To evaluate the staging of patients with colorectal adenocarcinoma treated at the Coloproctology Department of the Hospital Nossa Senhora da Conceição between 2010 and 2015. Method: Prevalence study. Data collection was performed retrospectively through a survey in the electronic system of the Hospital Group Conceição, seeking all patients with ICD 10 C18, C19 and C20 who were attended at the Coloproctology Department between 2010 and 2015. Results: Four hundred and twenty patients were eligible for the study. The mean age was 65.6 years (±12.8). Regarding staging, we observed the following distribution: 7.9%, stage I; 23.6%, stage II; 37.6%, stage III; and 30.2%, stage IV. The percentage of patients with advanced colorectal adenocarcinoma (stage III + stage IV) is 67.8%. Regarding the origin, 51% of the patients were attended at the emergency department. Conclusion: Most patients treated at this hospital have advanced disease (67%) and come from the emergency department (51%).
RESUMO Introdução: O câncer colorretal tem a segunda maior prevalência e a terceira maior incidência no mundo. A mortalidade está diretamente relacionada ao estágio da doença. Objetivo: Avaliar o estadiamento de pacientes com adenocarcinoma colorretal atendidos pelo Serviço de Coloproctologia do Hospital Nossa Senhora da Conceição (HNSC) entre os anos de 2010 e 2015. Método: Estudo de prevalência. A coleta de dados foi realizada de forma retrospectiva através de pesquisa no sistema eletrônico do Grupo Hospitalar Conceição buscando todos os pacientes com CID 10 C18, C19 e C20 atendidos pelo serviço de Coloproctologia entre os anos de 2010 e 2015. Resultados: Foram elegíveis para o estudo 420 pacientes. A média de idade foi de 65,6 anos (±12,8). Quanto ao estadiamento, observamos a seguinte distribuição: 7,9% estágio I; 23,6% estágio II; 37,6% estágio III e 30,2% estágio IV. O percentual de pacientes com adenocarcinoma colorretal avançado (estágio III + estágio IV) é de 67,8%. Em relação à origem, 51% dos pacientes foram atendidos através da emergência. Conclusão: A maioria dos pacientes atendidos neste hospital apresenta doença avançada (67%) e são oriundos do serviço de emergência (51%).
Assuntos
Humanos , Masculino , Feminino , Neoplasias Colorretais/epidemiologia , Estadiamento de Neoplasias , Neoplasias Colorretais/diagnóstico , Adenocarcinoma , Estudos Transversais , ColonoscopiaRESUMO
PURPOSE: The association of pregnancy and Cushing's disease (CD) is rare. Treatment of Cushing's syndrome (CS) is imperative to reduce maternal and fetal morbidity. Ketoconazole is a widely used drug for CS control when the woman is not pregnant but concerns about its teratogenicity and embryotoxicity restricted its use during pregnancy. METHODS AND RESULTS: We describe a case of a CD patient managed with Ketoconazole during the first and second trimester and other cares for her metabolic CS aspects during pregnancy. She delivered a normal female baby. CONCLUSIONS: It is supposed that even with treatment the relatively hypercortisolemic mother could protect her child from the embryotoxicity of ketoconazole as proved in rat fetuses and we suggest that ketoconazole could be an emergency pharmacological therapeutic option for CS management during pregnancy.
