RESUMO
The effects of graded doses of ethyl alcohol on defence behaviour were studied in nine cats: 0.25 g/kg of body weight had a slight but not significant excitatory effect, 0.5 and 1.0 g/kg had no effect and 1.5 g/kg significantly depressed some behavior components. When taking the scores for all the manifestations combined as an index of gross behaviour, 0.25 significantly intensified, 0.5 and 1.0 did not change and 1.5 g alcohol/kg significantly depressed defence. These results are consistent with the expected effects of alcohol on physiological functions in general.
Assuntos
Agressão/efeitos dos fármacos , Comportamento Animal/efeitos dos fármacos , Etanol/farmacologia , Animais , Gatos , Relação Dose-Resposta a Droga , Estimulação Elétrica , Etanol/administração & dosagem , Humanos , Hipotálamo/fisiologia , MasculinoRESUMO
The ventromedial hypothalamus of the unrestrained cat was stimulated electrically through permanent electrodes. The stimulation parameters, amplitude, duration and frequency of the square wave pulses were combined to produce a 20% increase of the resting heart rate value. The total electric charge for each parametric combination was calculated. The charge per stimulation (10 s) varied from about 1 to 100 micro-coulombs, depending on the parametric combination used. The response could therefore not be expressed as a function of the charge but depended on the individual parametric combinations. The relation among the stimulation parameters and the total amount of electric charge of the pulses was estimated by the correlation technique. The results suggested that about 60% of the variation in the electric charge resulting in the constant response was due to the variation of the pulse repetition frequency. The optimal parameters for eliciting cardio-acceleration in the cat by stimulation of the ventromedial hypothalamus seem to be pulse durations between 0.1 and 0.5 ms and pulse repetition frequencies below 100 P/s, with pulse amplitude as the dependent variable.
