RESUMO
Immunomorphological analysis revealed the presence of thymalin in human epidermis and in fetal reticuloepithelium. These structures are developed from the common embryonic primordium ectoderm. In embryos and adult humans thymalin is present only in young epidermal cells, which undergo age-related involution. By the age of 70 years, the layer of thymalin-containing cells looks thinned and discontinuous. The content of thymalin, a thymic factor, decreases with age.
Assuntos
Envelhecimento , Epiderme/química , Hormônios do Timo/análise , Adulto , Idoso , Células Epidérmicas , Epiderme/embriologia , Idade Gestacional , Cabelo/química , Cabelo/embriologia , HumanosRESUMO
Blast transformation of peripheral blood lymphocytes stimulated with phytohemagglutinin and concanavalin A was studied in children with pyelonephritis and glomerulonephritis. Activity of natural killer cells from children with pyelonephritis was estimated before and after treatment with 50% autologous plasma. The autologous plasma modulated blast transformation of lymphocytes and activity of natural killer cells, which depended on the stage of diseases.
Assuntos
Concanavalina A/farmacologia , Linfócitos/metabolismo , Fito-Hemaglutininas/metabolismo , Adolescente , Criança , Pré-Escolar , Glomerulonefrite/sangue , Humanos , Tolerância Imunológica , Imunoterapia , Células K562 , Células Matadoras Naturais/metabolismo , Ativação Linfocitária , Pielonefrite/sangueRESUMO
The endocrine function of the thymus develops earlier than lymphocytopoietic. Thymalin is produced by epithelial cells in the thymus primordium. It is released into the blood and regulates differentiation of T lymphocytes in the liver, the initial hemopoietic organ. The hormonal and lymphopoietic functions of human thymus are united on weeks 7.5-8 of embryonic life.
