COX-2 inhibitors: a potential target for drug therapy in the management of colorectal cancer.

Colorectal cancer is currently the third most common cancer in Malaysia. Elevated expression of COX-2, an induced cyclooxygenase isoenzyme, has been seen in colonic adenomas and colorectal carcinoma. There is evidence that inhibition of this COX-2 can decrease the risk of colorectal cancer. Selective COX-2 inhibitors may have a role in reducing the risk of colorectal cancer in high-risk individuals.

Total cutaneous harvesting from an amputated foot--two free flaps used for acute reconstruction.

Loss of weight-bearing skin of the foot produces a difficult reconstructive problem. A case is presented of severe bilateral lower limb trauma in which the right leg was amputated below the knee and two free flaps taken from the amputated foot were used for cover of the damaged left foot and the amputation stump.