Assuntos
Vírus da Influenza A/imunologia , Seleção Genética , Transformação Genética , Anticorpos Antivirais/biossíntese , Antígenos Virais/genética , Antígenos Virais/imunologia , Variação Genética , Humanos , Vírus da Influenza A/genética , Influenza Humana/imunologia , Influenza Humana/microbiologia , Mutação , Replicação ViralRESUMO
The authors studied the peculiarities of the course of experimental influenza infection induced by the administration of highly and poorly immunogenic strains of influenza virus to mice. Influenza viruses with varying immunogenic activity were obtained from the vaccine strain A/Victoria/35/72/50 (H3N2) by immunoselection modelling the process of natural selection. The administration of strains with high and poor immunogenicity to mice of the F1 (CBA X C57B1) line led to the development of acute influenza infection accompanied by reproduction of viruses in the tissue of the lungs and other internal organs. The poorly immunogenic strain 5/II-Victoria, unlike the initial virus A/Victoria/35 and its highly immunogenic variant 2/I-Victoria, is able to circulate for a long time in the organism of the infected animal causing development of chronic inflammatory processes and stimulating the formation of neoplasms. Immunogenicity is thus one of the factors determining the character of the course of experimental influenza infection. A conclusion was drawn concerning the epidemiological and aetiological importance of viruses with reduced immunogenicity and their role in the evolution of influenza virus. It is presumed that reduced immunogenicity is one of the adaptation mechanisms of aggression permitting the population of influenza virus to escape control by specific humoral immunity.
Assuntos
Vírus da Influenza A/imunologia , Infecções por Orthomyxoviridae/microbiologia , Animais , Replicação do DNA , Vírus da Influenza A/isolamento & purificação , Rim/microbiologia , Fígado/microbiologia , Pulmão/microbiologia , Camundongos , Camundongos Endogâmicos , Infecções por Orthomyxoviridae/imunologia , Baço/microbiologia , Replicação ViralRESUMO
A simple, practically feasible method based on neutralization of viruses with antibodies present in pools of placental immunoglobulin followed by their reactivation from the complex has been proposed for objective evaluation of the protection of the population against circulating variants of influenza virus and preliminary assessment of their antigenic novelty. The data obtained by this method show that the study may be done within a comparatively short period and will give an objective evaluation of the antigenic novelty and epidemic importance of various influenza virus strains with reference to the immunological status of the population in a definite region which permits one not only to determine the epidemic hazard of the strains for the present time but also to prognosticate it for the future.
