RESUMO
The aim of the study was to assess the role of the canonical Wnt/ß-catenin signaling pathway in the formation and clinical course of various histological variants of ameloblastoma. MATERIAL AND METHODS: 76 cases of ameloblastoma were investigated, the average age of the patients was 46 years. There were 49 (64.5%) cases of recurrence of the disease. Tissue antigens were determined using monoclonal rabbit antibodies to Ki-67 and ß-catenin. RESULTS: it was found correlation between the proliferative activity of ameloblastoma cells and the intranuclear localization of ß-catenin, indicating the activation of the Wnt/ß-catenin-signaling pathway. It was shown that the nuclear localization of ß-catenin is positively correlated with the recurrence. CONCLUSION: The Wnt/ß-catenin signaling pathway is involved in a formation and progression of ameloblastoma.
