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1.
Post Reprod Health ; : 20533691241240552, 2024 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-38753305

RESUMO

OBJECTIVE: The aim of the project was to reduce the risk of patients using the estrogen only part of their hormone replacement therapy (HRT) inadvertently in Banstead PCN. Although understanding about the risk of unopposed estrogen is well understood by prescribers, there are numerous flash points where this exposure can occur which was highlighted by several cases encountered during a study period of 3 months. STUDY DESIGN: Cases encountered revealed numerous reasons for this exposure which were split into three areas: Prescribing factors, dispensing checks and patient understanding. MAIN OUTCOME MEASURES: Quality improvement suggestions were tailored to the factors involved. IT system changes to EMIS, our main computer software provider, were proposed to enable safer prescribing. Following discussion with key stakeholders, increased education for pharmacists was proposed alongside an alert sticker system at the dispensing end point. Patient understanding and education for all parties was delivered through various routes. RESULTS: The IT system alterations required are complex and still awaited. Funding was obtained and stickers distributed. The results from a re-audit from this intervention are awaited. Interim education measures at an individual level were meantime explored and the impact of them assessed. Patient education and the role of social media were explored. I produced a short video which was circulated to doctors with the plan to distribute via other clinician social media accounts. CONCLUSIONS: A key discovery through this study is that many of the flash points identified can be difficult to detect and many are not measurable. The increasing number of HRT prescriptions, time pressures in primary care and the known risk from using unopposed estrogen of endometrial cancer means these changes are of potential great value.

2.
Post Reprod Health ; 30(2): 121-126, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38513147

RESUMO

Purpose: We performed a retrospective audit of General Practitioners' (GPs) referrals to the specialist Menopause Clinic at Guys and St Thomas's (GSTT) between 2021 and 2022. We aim to establish the indication for the referrals and whether they were compliant with the National Institute for Health and Care Excellence Guidance NICE.Background: GSTT is a teaching hospital in central London that educates gynaecologists in training as well as (GP) for specialist certification in Menopause. The menopause clinic receives approximately 580 GP referrals per month from South East London practices. The current waiting time for an initial appointment is up to 1 year. This delay reflects an increase in demand for menopause care and a deficit in service provision in many areas of the UK.NICE has recommended that GPs refer complicated cases to menopause specialists, with 11 specific criteria.Study Sample and Data Collection: We randomly selected 50 patients referred to the GSTT clinic by a GP between 2021 and 2022. Patient data were collected, including patient demographics, date of referral, indication for referral, date of consultation, waiting time, past medical history, investigations, and treatment instigated during the appointment.Results: The majority of referrals to the GSTT menopause Specialist clinic met the NICE guidelines (76%). One-sixth of the referrals could have been prevented or managed through alternative routes. Finally, although this is a small study, some patient unmet needs (PUNS) and GPs' educational needs have been identified.


Assuntos
Clínicos Gerais , Menopausa , Encaminhamento e Consulta , Humanos , Feminino , Encaminhamento e Consulta/estatística & dados numéricos , Estudos Retrospectivos , Pessoa de Meia-Idade , Clínicos Gerais/estatística & dados numéricos , Londres , Adulto , Idoso , Auditoria Médica , Fidelidade a Diretrizes/estatística & dados numéricos
4.
BMJ Open ; 12(11): e061505, 2022 11 21.
Artigo em Inglês | MEDLINE | ID: mdl-36410837

RESUMO

OBJECTIVES: To explore the events perceived as traumatic by obstetricians and gynaecologists (O&G), and to examine factors contributing to the perception of trauma. DESIGN: Mixed methods: cross-sectional survey and in-depth interviews. SAMPLE AND SETTING: Fellows, members and trainees of the Royal College of Obstetricians and Gynaecologists (RCOG). METHODS: An online survey was distributed to 6300 fellows (May-June 2017), members and trainees of RCOG; 1095 (17%) completed surveys were returned. Of these, 728 (66%) reported work-related trauma experience, with 525 providing a brief description of an event. Forty-three participants with trauma experience were purposively sampled and completed an in-depth interview (October 2017-March 2018), which were analysed using Template Analysis. Information regarding the scale and impact of trauma experience is presented elsewhere. The present analysis provides new information describing the events and perceptions of why events were traumatic. PRIMARY OUTCOME MEASURES: The nature of traumatic events in this clinical setting, taken from survey descriptions of perceived traumatic events and information from the in-depth interviews. RESULTS: Events perceived as traumatic by O&G were similar between consultants, trainees and other RCOG members no longer working in O&G. Maternal or neonatal death/stillbirth, haemorrhage and events involving a difficult delivery were most frequently reported. Sudden and unpredictable events, perceived preventability, acute sensory experiences and high emotionality contributed to trauma perception. Respondents' trauma was compounded by an absence of support, involvement in investigation procedures and pre-existing relationships with a recipient of care. CONCLUSIONS: Identification of events most likely to be perceived as traumatic, and wider circumstances contributing to the perception of trauma, provide a basis on which to focus preventative and supportive strategies for O&G. Training on the nature of traumatic events, self-help for early stress responses, processing support and rapid access to trauma-focused psychological input (where required) are needed.


Assuntos
Consultores , Pessoal de Saúde , Gravidez , Feminino , Recém-Nascido , Humanos , Estudos Transversais , Inquéritos e Questionários , Natimorto
5.
Post Reprod Health ; 28(4): 244-247, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36165129

RESUMO

OBJECTIVE: To determine whether a staff menopause clinic would benefit our peri/postmenopausal hospital workforce. METHODS: The three menopause consultants, with OH administration assistance, set up a virtual clinic for staff members to address the unanswered need for access to good menopause care. Feedback was gathered from the attendees and the staff who ran the clinic. RESULTS: The clinic was an overwhelming success and has now become an established clinic at a major London teaching hospital. CONCLUSIONS: We hope that this model can be used in other trusts, and other companies to provide good menopause care to our senior female workforce to retain them. Acknowledgements: We would like to thank the OH staff who ensured the clinics ran so smoothly.


Assuntos
Menopausa , Medicina Estatal , Feminino , Humanos , Recursos Humanos , Londres
6.
Lancet ; 399(10343): 2250-2252, 2022 06 18.
Artigo em Inglês | MEDLINE | ID: mdl-35658978
7.
Post Reprod Health ; 28(1): 28-39, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34818947

RESUMO

The NICE Guideline (NG23) 2015 Menopause: Diagnosis and Management states that 'women who are likely to go through the menopause as a result of medical or surgical treatment should be offered support and information about the menopause and fertility before they have their treatment, and a referral to a Health Care Professional with expertise in the menopause'. To investigate whether discussion about the surgery causing the menopause, and advice on possible treatments had been documented, I conducted a retrospective study of women undergoing bilateral oophorectomy at a central London teaching hospital from 1st April 2018 to 30th September 2018. Only 30% of women (8 out of 27) in this study had documentary evidence of having received menopause advice around the time of bilateral oophorectomy.


Assuntos
Menopausa , Feminino , Humanos , Londres , Ovariectomia/efeitos adversos , Estudos Retrospectivos
8.
Post Reprod Health ; 27(4): 209-214, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34748453

RESUMO

The menopausal transition is associated with increasing sleep disorders including sleep apnoea and restless leg syndrome. Insomnia is the most common and is recognised as a core symptom of the menopause. Guidelines to support decision making for women with sleep problems during the menopausal transition are lacking. Sleep problems are associated with negative impacts on healthcare utilisation, quality of life and work productivity. Sleep deprivation is a risk factor for cardiovascular disease, diabetes, obesity and neurobehavioral dysfunction. Declining oestrogen is implicated as a cause of menopausal sleep disruption. Vasomotor symptoms (VMS) and menopausal mood disturbance are also factors in the complex aetiology. VMS commonly precipitate insomnia and, due to their prolonged duration, they often perpetuate the condition. Insomnia in the general population is most effectively treated with cognitive behavioural therapy (CBT) (also effective in the menopausal transition.) The associations of menopausal sleep disturbance with VMS and depression mean that other treatment options must be considered. Existing guidelines outline effectiveness of hormone replacement therapy (HRT), CBT and antidepressants. HRT may indirectly help with sleep disturbance by treating VMS and also via beneficial effect on mood symptoms. The evidence base underpinning menopausal insomnia often references risks associated with HRT that are not in line with current international menopause guidelines. This may influence clinicians managing sleep disorders, leading to hesitation in offering HRT, despite evidence of effectiveness. Viewing sleep symptoms on an axis of menopausal symptoms - towards vasomotor symptoms or towards mood symptoms may help tailor treatment options towards the symptom profile.


Assuntos
Distúrbios do Início e da Manutenção do Sono , Transtornos do Sono-Vigília , Feminino , Fogachos , Humanos , Menopausa , Qualidade de Vida , Distúrbios do Início e da Manutenção do Sono/terapia , Transtornos do Sono-Vigília/etiologia , Transtornos do Sono-Vigília/terapia
9.
PLoS One ; 16(9): e0257051, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34506535

RESUMO

It has been widely observed that adult men of all ages are at higher risk of developing serious complications from COVID-19 when compared with women. This study aimed to investigate the association of COVID-19 positivity and severity with estrogen exposure in women, in a population based matched cohort study of female users of the COVID Symptom Study application in the UK. Analyses included 152,637 women for menopausal status, 295,689 women for exogenous estrogen intake in the form of the combined oral contraceptive pill (COCP), and 151,193 menopausal women for hormone replacement therapy (HRT). Data were collected using the COVID Symptom Study in May-June 2020. Analyses investigated associations between predicted or tested COVID-19 status and menopausal status, COCP use, and HRT use, adjusting for age, smoking and BMI, with follow-up age sensitivity analysis, and validation in a subset of participants from the TwinsUK cohort. Menopausal women had higher rates of predicted COVID-19 (P = 0.003). COCP-users had lower rates of predicted COVID-19 (P = 8.03E-05), with reduction in hospital attendance (P = 0.023). Menopausal women using HRT or hormonal therapies did not exhibit consistent associations, including increased rates of predicted COVID-19 (P = 2.22E-05) for HRT users alone. The findings support a protective effect of estrogen exposure on COVID-19, based on positive association between predicted COVID-19 with menopausal status, and negative association with COCP use. HRT use was positively associated with COVID-19, but the results should be considered with caution due to lack of data on HRT type, route of administration, duration of treatment, and potential unaccounted for confounders and comorbidities.


Assuntos
COVID-19/epidemiologia , Terapia de Reposição de Estrogênios , Estrogênios/metabolismo , Menopausa/metabolismo , Adulto , Estudos de Coortes , Comorbidade , Feminino , Humanos , Pessoa de Meia-Idade , Fatores de Risco , Reino Unido
13.
BMJ ; 367: l5928, 2019 10 11.
Artigo em Inglês | MEDLINE | ID: mdl-31604711
15.
J Sex Med ; 16(9): 1331-1337, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31488288

RESUMO

This Statement is being simultaneously published in the journals Climacteric, Maturitas, Journal of Sexual Medicine, and Journal of Clinical Endocrinology and Metabolism on behalf of the International Menopause Society, The European Menopause and Andropause Society, The International Society for Sexual Medicine, and The Endocrine Society, respectively. This Position Statement has been endorsed by the International Menopause Society, The Endocrine Society, The European Menopause and Andropause Society, The International Society for Sexual Medicine, The International Society for the Study of Women's Sexual Health, The North American Menopause Society, The Federacion Latinoamericana de Sociedades de Climaterio y Menopausia, The Royal College of Obstetricians and Gynaecologists, The International Society of Endocrinology, The Endocrine Society of Australia, and The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.


Assuntos
Androgênios/uso terapêutico , Consenso , Terapia de Reposição Hormonal , Disfunções Sexuais Fisiológicas/tratamento farmacológico , Disfunções Sexuais Psicogênicas/tratamento farmacológico , Testosterona/uso terapêutico , Feminino , Saúde Global , Humanos
16.
J Clin Endocrinol Metab ; 104(10): 4660-4666, 2019 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-31498871

RESUMO

This Position Statement has been endorsed by the International Menopause Society, The Endocrine Society, The European Menopause and Andropause Society, The International Society for Sexual Medicine, The International Society for the Study of Women's Sexual Health, The North American Menopause Society, The Federacion Latinoamericana de Sociedades de Climaterio y Menopausia, The Royal College of Obstetricians and Gynecologists, The International Society of Endocrinology, The Endocrine Society of Australia, and The Royal Australian and New Zealand College of Obstetricians and Gynecologists.


Assuntos
Androgênios/uso terapêutico , Disfunções Sexuais Fisiológicas/tratamento farmacológico , Disfunções Sexuais Psicogênicas/tratamento farmacológico , Testosterona/uso terapêutico , Feminino , Humanos , Uso Off-Label , Pós-Menopausa , Pré-Menopausa , Disfunções Sexuais Fisiológicas/diagnóstico , Disfunções Sexuais Fisiológicas/metabolismo , Disfunções Sexuais Psicogênicas/diagnóstico , Disfunções Sexuais Psicogênicas/metabolismo , Testosterona/metabolismo
19.
Br J Nurs ; 25(17): 978-983, 2016 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-27666099

RESUMO

Female genital mutilation (FGM) is a traditional practice that has no medical benefit and severe health consequences for girls and women. This article discusses the risks to patients who are pregnant and have had FGM. It will describe urinary tract infections caused by FGM, and how this condition increases the risk of preterm labour and delivery. It will also address the difficulty in vaginal examinations that can be caused by FGM and instances when this can delay diagnosis and treatment. In addition, it will explore a number of intrapartum risks caused by FGM and the role of deinfibulation in pregnancy. Finally, it will look at the link between maternal and fetal morbidity and mortality, and FGM.


Assuntos
Circuncisão Feminina , Complicações do Trabalho de Parto , Complicações na Gravidez , Cesárea , Parto Obstétrico , Episiotomia , Feminino , Exame Ginecológico , Humanos , Lacerações , Tempo de Internação , Períneo/lesões , Hemorragia Pós-Parto , Gravidez , Complicações Infecciosas na Gravidez , Cuidado Pré-Natal , Cateterismo Urinário , Infecções Urinárias
20.
J Clin Endocrinol Metab ; 101(9): 3497-505, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-27340881

RESUMO

CONTEXT: Women with premature ovarian failure (POF) face many years of estrogen deficiency. One of the major consequences is bone loss. The optimal form of estrogen replacement is unknown and management is not evidence based. The 2 broad options are combined hormone replacement therapy (HRT) or the combined oral contraceptive pill (COCP). OBJECTIVES: To compare the effects of HRT and COCP on bone density and turnover in women with spontaneous POF and to observe the effects of no treatment. DESIGN: Two-year open randomized trial comparing HRT and COCP and nonrandomized observation of women declining treatment using the same protocol. SETTING: London teaching hospital. PARTICIPANTS: A total of 59 women with spontaneous POF aged 18-44, 30 women elected to take treatment and were randomized, and 29 declined treatment. INTERVENTION: Randomization was to HRT (Nuvelle) or COCP (Microgynon 30). MAIN OUTCOME MEASURES: The primary outcome was change in lumbar spine bone mineral density. Changes in total hip and femoral neck bone density and bone turnover markers were also assessed. RESULTS: A total of 36 women (61%) completed the trial (no treatment 52%; HRT 60%; COCP 80%). In comparison with COCP, treatment with HRT increased bone density at the lumbar spine at 2 years (+0.050 g/cm(2); 95% confidence interval 0.007-0.092; P = .025). Bone turnover markers showed similar reductions in the 2 treatment groups. In the no treatment group, bone density dropped at all sites and bone turnover markers remained relatively unchanged. CONCLUSIONS: The results suggest that HRT is superior to COCP in increasing bone density at the lumbar spine in women with spontaneous POF. The limitations of a small sample size and high drop-out rate mean that further research is required to confirm the findings. However, either treatment is clearly superior to no treatment.


Assuntos
Densidade Óssea/efeitos dos fármacos , Anticoncepcionais Orais Combinados/uso terapêutico , Terapia de Reposição Hormonal , Insuficiência Ovariana Primária/tratamento farmacológico , Adolescente , Adulto , Estudos de Casos e Controles , Feminino , Seguimentos , Humanos , Prognóstico , Adulto Jovem
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