1.
Bioorg Med Chem Lett
; 23(7): 2134-9, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23434029
RESUMO
Development of SAR in a 5-aryl-3-acylpyridinyl-pyrazoles and 1-aryl-4-acylpyridinyl imidazoles series of mGlu5 receptor negative allosteric modulators (mGluR5 NAMs) using a functional cell-based assay is described in this Letter. Analysis of the Ligand-lipophilic efficiency (LipE) of compounds provided new insight for the design of potent mGluR5 negative allosteric modulators with anti-depressant activities.
