Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 12 de 12
Filtrar
Mais filtros











Intervalo de ano de publicação
3.
Mundo Saúde (Online) ; 47: e15282023, 2023.
Artigo em Inglês, Português | LILACS-Express | LILACS | ID: biblio-1519246

RESUMO

A realização de diagnóstico e tratamento das arritmias sustentadas fazem parte da rotina clínica, sendo uma das arritmias mais frequentes a Fibrilação Atrial (FA). Para prevenção de eventos tromboembólicos em pacientes com FA, recomendase a anticoagulação oral, destacando-se a varfarina. Apesar da importância, esse medicamento possui estreita margem terapêutica, o que faz com que pequenas mudanças no tratamento gerem risco de eventos trombóticos ou hemorrágicos. Dentre essas mudanças, destaca-se a adesão aos demais medicamentos em uso, alteração do uso desses medicamentos por prescritores e automedicação. Várias são as interações entre varfarina e demais medicamentos de uso contínuo, acreditando-se que a complexidade da prescrição pode interferir nos desfechos clínicos da terapia anticoagulante. O objetivo do estudo foi caracterizar pacientes acompanhados em um ambulatório de anticoagulação em relação ao Índice de Complexidade da Farmacoterapia. Para identificação da complexidade da farmacoterapia, considerou-se as prescrições dos demais medicamentos em uso, prescritas por médicos da atenção primária em saúde. Utilizouse o instrumento Medication Regimen Complexity Index (MRCI). A complexidade, compreendida como a forma de administração, posologia e forma farmacêutica, fatores que interferem na adesão à terapia anticoagulante, foi subdividida em três níveis: baixa complexidade, moderada e alta, conforme indicado pela literatura. A análise da complexidade foi realizada por dois pesquisadores de forma independente, sendo considerados os critérios conforme orientação do MRCI. Trata-se de um estudo descritivo realizado em duas clínicas de anticoagulação, localizadas em Minas Gerais. Durante a pesquisa, pacientes foram acompanhados em dois ambulatórios de anticoagulação do Brasil, em uso de varfarina, foram convidados a participarem de um ensaio clínico entre dezembro de 2018 e fevereiro de 2019, sendo que posteriormente foi realizado um recorte para o presente estudo. Um total de 93 pacientes foram incluídos no estudo, sendo a média de idade de 63 anos e a maioria do sexo feminino (68,8%). A fibrilação atrial foi a indicação da ACO mais predominante (92,5%). A média do número de medicamentos utilizados foi de 7,0. A maioria dos pacientes com farmacoterapia classificada como alta (38, 6,5%) e média complexidade (24, 80,7%) apresentou TTR inadequado. O presente estudo permitiu identificar que há um predomínio de pacientes com alta complexidade da farmacoterapia, o que pode indicar necessidades de cuidados adicionais em relação ao tratamento anticoagulante. Para tanto, em casos de pacientes com controle inadequado da anticoagulação oral, recomenda-se que aspectos da complexidade da farmacoterapia sejam incorporados na abordagem educacional.


Diagnosis and treatment of sustained arrhythmias are part of the clinical routine, with one of the most frequent arrhythmias being Atrial Fibrillation (AF). To prevent thromboembolic events in patients with AF, oral anticoagulation is recommended, particularly warfarin. Despite its importance, this medication has a narrow therapeutic range, which means that small changes in treatment generate a risk of thrombotic or hemorrhagic events. Among these changes, adherence to other medications in use, changes in the use of these medications by prescribers and self-medication stand out. There are several interactions between warfarin and other medications for continuous use, with the belief that the complexity of the prescription may interfere with the clinical outcomes of anticoagulant therapy. The objective of the study was to characterize patients followed in an anticoagulation outpatient clinic in relation to the Pharmacotherapy Complexity Index. To identify the complexity of pharmacotherapy, prescriptions for other medications in use, prescribed by primary health care doctors, were considered. The Medication Regimen Complexity Index (MRCI) instrument was used. Complexity, understood as the form of administration, dosage and pharmaceutical form, factors that interfere with adherence to anticoagulant therapy, was subdivided into three complexity levels: low, moderate and high, as indicated in the literature. The complexity analysis was carried out by two researchers independently, considering the criteria as per MRCI guidance. This is a descriptive study carried out in two anticoagulation clinics, located in Minas Gerais. During the research, patients were monitored in two anticoagulation clinics in Brazil, using warfarin, and were invited to participate in a clinical trial between December 2018 and February 2019, and a selection was subsequently made for the present study. A total of 93 patients were included in the study, the average age was 63 years and the majority were female (68.8%). Atrial fibrillation was the most predominant OAC indication (92.5%). The average number of medications used was 7.0. The majority of patients with pharmacotherapy classified as high (38, 6.5%) and medium complexity (24, 80.7%) presented inadequate TTR. The present study identified that there is a predominance of patients with high complexity of pharmacotherapy, which may indicate the need for additional care in relation to anticoagulant treatment. Therefore, in cases of patients with inadequate control of oral anticoagulation, it is recommended that aspects of the complexity of pharmacotherapy be incorporated into the educational approach.

5.
Braz. j. vet. pathol ; 15(3): 153-156, nov. 2022. ilus
Artigo em Inglês | VETINDEX | ID: biblio-1417393

RESUMO

Canine facial eosinophilic furunculosis (FEF) is a hyperacute dermatopathy especially of the nasal bridge of dogs and is probably associated with type I hypersensitivity secondary to arthropod bites. The aim of this study is to report on a FEF case in a four-year-old female free-roaming mixed-breed dog showing papules on the nasal bridge that evolved to an ulcerated plaque. No other clinical, hematological, or biochemical alterations were detected. Cytology revealed eosinophilic and neutrophilic inflammation associated with bacterial infection. Punch biopsies were obtained for histopathological and microbiological analysis. Histopathology revealed marked, acute, multifocal to coalescent granulomatous eosinophilic furunculosis, and mild, acute, multifocal eosinophilic folliculitis. Microbiology revealed growth of coagulase-positive Staphylococcus sp. Clinical and histopathological findings were suggestive of facial eosinophilic folliculitis and furunculosis. Complete remission of the lesions was obtained after treatment. This condition is hyperacute, progressive, with a papular and erosive to ulcerative pattern, good prognosis, and its development is linked to arthropod bites. Furthermore, anti-inflammatory therapy is effective in treating the disease.(AU)


Assuntos
Animais , Feminino , Cães , Dermatoses Faciais/veterinária , Furunculose/diagnóstico , Biópsia/veterinária , Doenças do Cão , Eosinófilos
6.
New Phytol ; 236(2): 698-713, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-35811430

RESUMO

The biogeography of neotropical fungi remains poorly understood. Here, we reconstruct the origins and diversification of neotropical lineages in one of the largest clades of ectomycorrhizal fungi in the globally widespread family Russulaceae. We inferred a supertree of 3285 operational taxonomic units, representing worldwide internal transcribed spacer sequences. We reconstructed biogeographic history and diversification and identified lineages in the Neotropics and adjacent Patagonia. The ectomycorrhizal Russulaceae have a tropical African origin. The oldest lineages in tropical South America, most with African sister groups, date to the mid-Eocene, possibly coinciding with a boreotropical migration corridor. There were several transatlantic dispersal events from Africa more recently. Andean and Central American lineages mostly have north-temperate origins and are associated with North Andean uplift and the general north-south biotic interchange across the Panama isthmus, respectively. Patagonian lineages have Australasian affinities. Diversification rates in tropical South America and other tropical areas are lower than in temperate areas. Neotropical Russulaceae have multiple biogeographic origins since the mid-Eocene involving dispersal and co-migration. Discontinuous distributions of host plants may explain low diversification rates of tropical lowland ectomycorrhizal fungi. Deeply diverging neotropical fungal lineages need to be better documented.


Assuntos
Basidiomycota , Micorrizas , Micorrizas/genética , Filogenia , Filogeografia , América do Sul
7.
Transfusion ; 60(9): 2139-2143, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32735379

RESUMO

CASE REPORT: A 26-year-old woman with sickle cell disease (SCD) on chronic transfusion therapy complained of severe arthralgia, myalgia, abdominal pain, headache, and fever 24 hours after transfusion of a red blood cells (RBCs). Dengue virus (DENV) infection was suspected and the patient was hospitalized for clinical support and RBC transfusion, to lower the hemoglobin S to less than 30%. The patient's clinical condition improved approximately 8 days after the onset of symptoms. RESULTS: DENV type 2 (DENV-2) TaqMan real-time polymerase chain reaction was negative in the patient's pretransfusion sample while the posttransfusion sample was positive (Ct, 27.8), suggesting a high viral load and an acute infection. To investigate DENV transfusion transmission (TT-DENV) the stored donor serum was tested and was also positive (Ct, 25.8). Molecular typing confirmed the presence of DENV-2. The phylogenetic analysis of the DENV-2 strains obtained from both donor and patient samples were classified as the Southeast Asia-American genotype (Genotype III) and demonstrated 100% genomic identity, indicating TT-DENV. CONCLUSION: This is the first description of TT-DENV in a SCD patient. A presumed high viral load in the transfused RBC unit probably determined the early clinical manifestation. In endemic regions dengue fever should be considered as differential diagnosis in SCD patients with fever and acute pain crisis, mainly during DENV outbreaks.


Assuntos
Anemia Falciforme , Vírus da Dengue , Dengue , Transfusão de Eritrócitos/efeitos adversos , Vasoconstrição , Adulto , Anemia Falciforme/sangue , Anemia Falciforme/fisiopatologia , Anemia Falciforme/terapia , Dengue/sangue , Dengue/etiologia , Dengue/fisiopatologia , Feminino , Humanos , Reação Transfusional/sangue , Reação Transfusional/fisiopatologia
8.
Fisioter. Bras ; 21(2): 174-181, Mai 16, 2020.
Artigo em Português | LILACS | ID: biblio-1282904

RESUMO

Introdução: O Diabetes Mellitus tipo 2 (DM2) é considerado um dos principais problemas da saúde pública. Assim, uma das complicações a longo prazo está relacionada as alterações de sensibilidade principalmente na região podal. Objetivo: Comparar os efeitos entre as técnicas de estimulação sensorial em diferentes texturas e o banho de contraste para melhora da sensibilidade plantar de indivíduos diabéticos tipo 2. Métodos: Trata-se de um ensaio clínico randomizado, no qual os indivíduos foram inclusos por ordem de adesão através de sorteio, sendo 6 participantes do circuito com estações em diferentes texturas (GDT) e 6 participantes do revezamento em banho de contraste (GBC) com idade média de 63 ± 12 e 56 ± 11 anos. A avaliação sensitiva foi realizada em 9 pontos dos pés, antes e após 24 intervenções fisioterapêuticas, sendo aplicadas 5 dias por semana. Resultados: Tanto a técnica GDT quanto a GBC apresentaram melhora significativa, com o valor de p < 0,0001 comparando o antes e depois. A variável entre os grupos obteve o resultado de 0,0258. Conclusão: Foi possível identificar que as duas técnicas promoveram a melhora da sensibilidade plantar de forma significativa, evidenciando que a técnica do banho de contraste mostrou-se mais eficaz comparada a variável do protocolo de diferentes texturas. (AU)


Introduction: Diabetes Mellitus type 2 (DM2) is considered one of the major public health problems. Thus, one of the long-term complications is related to changes in sensitivity, especially in the foot region. Objective: To compare the effects between sensory stimulation techniques in different textures and the contrast bath to improve plantar sensitivity of type 2 diabetic individuals. Methods: This is a randomized clinical trial, in which the individuals were included by order of adherence by lottery, being 6 participants in the circuit with stations in different textures (GDT) and 6 participants in the contrast bath relay (GBC) with mean age of 63 ± 12 and 56 ± 11 years. The sensory evaluation was performed in 9 points of the feet before and after 24 physiotherapeutic interventions, being applied 5 days a week. Results: Both the GDT and GBC techniques showed significant improvement, with the value of p < 0.0001 comparing the before and after. The variable between the groups obtained the result of p < 0.0258. Conclusion: It was possible to identify that both techniques promoted the return of plantar sensitivity significantly, showing that the contrast bath technique was more effective compared to the protocol variable of different textures. (AU)


Assuntos
Humanos , Modalidades de Fisioterapia , Diabetes Mellitus , Neuropatias Diabéticas , Métodos
9.
Sci Total Environ ; 659: 401-409, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31096371

RESUMO

While most soils in periglacial environments present high fluxes of CO2 (FCO2), CH4 (FCH4), and N2O (FN2O), few of them have a tendency to drain greenhouse gases from the atmosphere. This study aimed to assess greenhouse gas fluxes at different sub-Antarctic sites and time periods (at the beginning of thaw and height of summer). To investigate the time of year effect on greenhouse gas emissions, FCO2, FCH4, and FN2O were measured at two sites tundra-covered (Ti and Th) and Nothofagus forest soil (Nf) on Monte Martial, at the southernmost tip of South America, Tierra del Fuego, Argentina. FCO2 ranged from 96.33 to 225.72 µg CO2 m-2 s-1 across all sites and periods, showing a positive correlation with soil temperature (Ts) (4.1 and 8.2 °C, respectively) (r2 > 0.7; p < 0.05). The highest values of FCO2 were found at Ti and Th (728.2 and 662.64 µg CO2 m-2 s-1, respectively), which were related to higher temperatures (8.2 and 8.6 °C, respectively) when compared to those of Nf. For FCH4, the capture (drain) occurred during both periods at Nf (-26 and -79 µg C-CH4 m-2 h-1) as well as Ti and Th (-21 and 12 µg C-CH4 m-2 h-1, respectively). FN2O also presented low values during both periods and showed a tendency to drain N2O from the atmosphere, especially at Nf (-2 µg N-N2O m-2 h-1). In addition, FN2O was slightly positive for Ti and Th (0.3 and 0.55 µg N-N2O m-2 h-1, respectively). Soil moisture did not show a correlation (p > 0.05) with the measured greenhouse gas fluxes. A scenario of increased temperatures might result in changes in the balance between the emissions and drains of these gases from soils, leading to higher emission values of CH4 and N2O, especially for tundra covered soils (Ti and Th), where the highest average fluxes and thermohydric variations were observed over the year.

10.
Conscientiae saúde (Impr.) ; 17(4): 443-453, dez. 2018.
Artigo em Português | LILACS | ID: biblio-987377

RESUMO

Introdução: O fibro edema gelóide (FEG) ocasiona deformações locais no tecido subcutâneo. Correntes excito motoras, como a corrente russa (CR), e métodos que associam efeitos mecânicos e térmicos no tecido, como o ultrassom (US), são usados para tratar a FEG. O US pode ainda ser aplicado com a fonoforese (FN) para aumentar a absorção percutânea de princípios ativos. Objetivo: Verificar o efeito da CR associada ao US ou à FN no tratamento da FEG em glúteos e coxas de mulheres jovens. Métodos: Participaram mulheres com FEG que realizaram 10 sessões de CR com US ou com FN. As voluntárias foram avaliadas antes e após os tratamentos. Resultados: Obteve-se diminuição da espessura das dobras cutâneas, redução do grau de FEG, redução da distorção da imagem corporal e índice de satisfação elevado das voluntárias com os resultados de ambos tratamentos, porém a FN associada à CR apresentou efeito mais evidente. Conclusão: Os tratamentos utilizados fornecem resultados rápidos e satisfatórios na redução do FEG.


Introduction: Geloid fibroedema (GF) or Cellulitis causes local deformations in the subcutaneous tissue. Electric Stimulation Therapy, such as the Russian Current (RC), and methods associating mechanical and thermal effects on tissue, such as Ultrasound (US), are used to treat GF. US can still be applied with Phonophoresis (Ph) to increase percutaneous absorption of active principles. Objective: To verify the effect of RC associated with US or Ph in the treatment of GF in glutes and thighs of young women. Methods: GF women who performed 10 sessions of RC with US or with Ph participated. The volunteers were evaluated before and after the treatments. Results: There was a reduction in the thickness of the skin folds, reduction of the GF degree, reduction of the body image distortion and high index of satisfaction of the volunteers with the results of both treatments, but the Ph associated to the CR showed a more evident effect. Conclusion: The treatments used provide fast and satisfactory results in the reduction of GF.


Assuntos
Humanos , Feminino , Adulto , Adulto Jovem , Terapia por Ultrassom , Fonoforese , Celulite/terapia , Estudos Prospectivos
11.
Conscientiae saúde (Impr.) ; 17(2): 187-195, jun. 2018.
Artigo em Português | LILACS | ID: biblio-916238

RESUMO

Introdução: As crianças com atrasos no desenvolvimento motor devem receber ações específicas, visto que os problemas relacionados com o controle do movimento poderão perdurar até a fase adulta. Objetivo: Analisar a influência de uma intervenção psicomotora sobre o desenvolvimento motor e os níveis de atenção em crianças com atrasos motores. Métodos: Foram avaliados 28 escolares de ambos os sexos, de 7 à 10 anos, com atrasos motores. Antes e após a intervenção, as crianças foram submetidas à avaliação motora, dos níveis de atenção, e das dificuldades na escrita. As crianças participaram de 20 sessões de um protocolo incluindo exercícios psicomotores. Para análise dos dados foi utilizado o teste t pareado e correlação de Pearson. Resultados: Houve melhora nas habilidades motoras avaliadas (<0,001), e nos níveis de atenção pós-intervenção (<0,001). Conclusão: O protocolo proposto contribuiu para o desenvolvimento das habilidades motoras e dos níveis de atenção das crianças.


Introduction: Children with motor development delays should be given specific actions, as problems related to movement control may persist into adulthood. Objective: To analyze the influence of a motor intervention on motor development and attention levels in children with motor delas. Methods: 28 Students of both sexes, aged 7 to 10 years, with motor delas were evaluated. Before and after the intervention, the children were submitted to motor evaluation, levels of attention, and difficulties in writing. The children participated in 20 sessions of a protocol including psychomotor exercises. The paired t-test and Pearson's correlation were used for data analysis. Results: There was improvement in motor skills assessed (<0.001), and at post-intervention attention levels (<0.001). Conclusion: The proposed protocol contributed to the development of motor skills and attention levels of children.


Assuntos
Humanos , Masculino , Feminino , Criança , Atenção , Desenvolvimento Infantil , Destreza Motora , Epidemiologia Descritiva , Escrita Manual
12.
Ecotoxicol Environ Saf ; 149: 197-202, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29175346

RESUMO

Endocrine disrupting compounds (EDCs) can be found in domestic sewage, wastewater treatment plant effluents, natural water, rivers, lakes and in the marine environment. Jurujuba Sound, located in the state of Rio de Janeiro, Southeastern Brazil, receives untreated sewage into its waters, one the main sources of aquatic contamination in this area. In this context, the aim of the present study was to evaluate the estrogenic potential of water sampled from different depths and from areas with differential contamination levels throughout Jurujuba Sound. Water quality was evaluated and acute toxicity assays using Allviibrio fischeri were conducted, while estrogenic activity of the water samples was determined by a Yeast Estrogen Screening assay (YES). Water quality was mostly within the limits established for marine waters by the Brazilian legislation, with only DOC and ammoniacal nitrogen levels above the maximum permissible limits. No acute toxicity effects were observed in the Allivibrio fisheri assay. The YES assay detected moderate estrogenic activity in bottom water samples from 3 sampling stations, ranging from 0.5 to 3.2ngL-1, as well as in one surface water sample. Estrogenic activity was most frequently observed in samples from the bottom of the water column, indicating adsorption of estrogenic compounds to the sediment.


Assuntos
Disruptores Endócrinos/análise , Monitoramento Ambiental/métodos , Estrogênios/análise , Água do Mar/química , Poluentes Químicos da Água/análise , Qualidade da Água , Adsorção , Aliivibrio fischeri/efeitos dos fármacos , Bioensaio , Brasil , Disruptores Endócrinos/toxicidade , Estrogênios/toxicidade , Estuários , Sedimentos Geológicos/química , Receptores de Estrogênio/metabolismo , Saccharomyces cerevisiae/efeitos dos fármacos , Saccharomyces cerevisiae/metabolismo , Poluentes Químicos da Água/toxicidade
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA