Performance evaluation of side-by-side optically coupled monolithic LYSO crystals.

BACKGROUND: Significant interest has been recently shown for using monolithic scintillation crystals in molecular imaging systems, such as positron emission tomography (PET) scanners. Monolithic-based PET scanners result in a lower cost and higher sensitivity, in contrast to systems based on the more conventional pixellated configuration. The monolithic design allows one to retrieve depth-of-interaction information of the impinging 511 keV photons without the need for additional hardware materials or complex positioning algorithms. However, the so-called edge-effect inherent to monolithic-based approaches worsens the detector performance toward the crystal borders due to the truncation of the light distribution, thus decreasing positioning accuracy. PURPOSE: The main goal of this work is to experimentally demonstrate the detector performance improvement when machine-learning artificial neural-network (NN) techniques are applied for positioning estimation in multiple monolithic scintillators optically coupled side-by-side. METHODS: In this work, we show the performance evaluation of two LYSO crystals of 33 × 25.4 × 10 mm3 optically coupled by means of a high refractive index adhesive compound (Meltmount, refractive index n = 1.70). A 12 × 12 silicon photomultiplier array has been used as photosensor. For comparison, the same detector configuration was tested for two additional coupling cases: (1) optical grease (n = 1.46) in between crystals, and (2) isolated crystals using black paint with an air gap at the interface (named standard configuration). Regarding 2D photon positioning (XY plane), we have tested two different methods: (1) a machine-learning artificial NN algorithm and (2) a squared-charge (SC) centroid technique. RESULTS: At the interface region of the detector, the SC method achieved spatial resolutions of 1.7 ± 0.3, 2.4 ± 0.3, and 2.6 ± 0.4 mm full-width at half-maximum (FWHM) for the Meltmount, grease, and standard configurations, respectively. These values improve to 1.0 ± 0.2, 1.2 ± 0.2, and 1.2 ± 0.3 mm FWHM when the NN algorithm was employed. Regarding energy performance, resolutions of 18 ± 2%, 20 ± 2%, and 23 ± 3% were obtained at the interface region of the detector for Meltmount, grease, and standard configurations, respectively. CONCLUSIONS: The results suggest that optically coupling together scintillators with a high refractive index adhesive, in combination with an NN algorithm, reduces edge-effects and makes it possible to build scanners with almost no gaps in between detectors.

Author Correction: High resolution and sensitivity gamma camera with active septa. A first Monte Carlo study.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Pilot performance of a dedicated prostate PET suitable for diagnosis and biopsy guidance.

BACKGROUND: Prostate cancer (PCa) represents one of the most common types of cancers facing the male population. Nowadays, to confirm PCa, systematic or multiparametric MRI-targeted transrectal or transperineal biopsies of the prostate are required. However, due to the lack of an accurate imaging technique capable to precisely locate cancerous cells in the prostate, ultrasound biopsies sample random parts of the prostate and, therefore, it is possible to miss regions where those cancerous cells are present. In spite of the improvement with multiparametric MRI, the low reproducibility of its reading undermines the specificity of the method. Recent development of prostate-specific radiotracers has grown the interest on using positron emission tomography (PET) scanners for this purpose, but technological improvements are still required (current scanners have resolutions in the range of 4-5 mm). RESULTS: The main goal of this work is to improve state-of-the-art PCa imaging and diagnosis. We have focused our efforts on the design of a novel prostate-dedicated PET scanner, named ProsPET. This system has small scanner dimensions defined by a ring of just 41 cm inner diameter. In this work, we report the design, implementation, and evaluation (both through simulations and real data) of the ProsPET scanner. We have been able to achieve < 2 mm resolution in reconstructed images and high sensitivity. In addition, we have included a comparison with the Philips Gemini-TF scanner, which is used for routine imaging of PCa patients. The ProsPET exhibits better contrast, especially for rod sizes as small as 4.5 mm in diameter. Finally, we also show the first reconstructed image of a PCa patient acquired with the ProsPET. CONCLUSIONS: We have designed and built a prostate specific PET system, with a small footprint and improved spatial resolution when compared to conventional whole-body PET scanners. The gamma ray impact within each detector block includes accurate DOI determination, correcting for the parallax error. The potential role of combined organ-dedicated prostate-specific membrane antigen (PSMA) PET and ultrasound devices, as a prebiopsy diagnostic tool, could be used to guide sampling of the most aggressive sites in the prostate.

Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs.

Monolithic scintillators are more frequently used in PET instrumentation due to their advantages in terms of accurate position estimation of the impinging gamma rays both planar and depth of interaction, their increased efficiency, and expected timing capabilities. Such timing performance has been studied when those blocks are coupled to digital photosensors showing an excellent timing resolution. In this work we study the timing behaviour of detectors composed by monolithic crystals and analog SiPMs read out by an ASIC. The scintillation light spreads across the crystal towards the photosensors, resulting in a high number of SiPMs and ASIC channels fired. This has been studied in relation with the Coincidence Timing Resolution (CTR). We have used LYSO monolithic blocks with dimensions of 50 × 50 × 15 mm3 coupled to SiPM arrays (8 × 8 elements with 6 × 6 mm2 area) which compose detectors suitable for clinical applications. While a CTR as good as 186 ps FWHM was achieved for a pair of 3 × 3 × 5 mm3 LYSO crystals, when using the monolithic block and the SiPM arrays, a raw CTR over 1 ns was observed. An optimal timestamp assignment was studied as well as compensation methods for the time-skew and time-walk errors. This work describes all steps followed to improve the CTR. Eventually, an average detector time resolution of 497 ps FWHM was measured for the whole thick monolithic block. This improves to 380 ps FWHM for a central volume of interest near the photosensors. The timing dependency with the photon depth of interaction and planar position are also included.

High resolution and sensitivity gamma camera with active septa. A first Monte Carlo study.

Gamma cameras are of great interest due to their high potential in the field of Nuclear Medicine Imaging. They allow for an early diagnosis of reduced size tumors, and also for a wide variety of preclinical studies with the aim of designing more effective treatments against cancer. In this work we propose a significantly improved multi-pinhole collimator gamma camera and perform a first Monte Carlo analysis of its characteristics. Maintaining the configuration of a multi-pinhole collimator with a high degree of overlapping (thus with a high sensitivity), we add a new element, an active septa, that besides acting as a collimator, is able to measure the impact coordinates of the incident photon. This way one is able to unambiguously identify through which pinhole any gamma ray passes before being detected. The result is a high sensitivity and resolution multi-pinhole gamma camera with an arbitrarily large field of view. As a consequence, the final reconstructed image does not suffer from the undesired artifacts or truncation associated to the multiplexing phenomenon. In this study we focus on the development of a system able to visualize in 3D tumors, nodes and metastasis in real time in the operating room with very low dose. We also briefly analyse and propose a novel design for a Single Photon Emission Computed Tomography system.

Feasibility Study of a Small Animal PET Insert Based on a Single LYSO Monolithic Tube.

There are drawbacks with using a Positron Emission Tomography (PET) scanner design employing the traditional arrangement of multiple detectors in an array format. Typically PET systems are constructed with many regular gaps between the detector modules in a ring or box configuration, with additional axial gaps between the rings. Although this has been significantly reduced with the use of the compact high granularity SiPM photodetector technology, such a scanner design leads to a decrease in the number of annihilation photons that are detected causing lower scanner sensitivity. Moreover, the ability to precisely determine the line of response (LOR) along which the positron annihilated is diminished closer to the detector edges because the spatial resolution there is degraded due to edge effects. This happens for both monolithic based designs, caused by the truncation of the scintillation light distribution, but also for detector blocks that use crystal arrays with a number of elements that are larger than the number of photosensors and, therefore, make use of the light sharing principle. In this report we present a design for a small-animal PET scanner based on a single monolithic annulus-like scintillator that can be used as a PET insert in high-field Magnetic Resonance systems. We provide real data showing the performance improvement when edge-less modules are used. We also describe the specific proposed design for a rodent scanner that employs facetted outside faces in a single LYSO tube. In a further step, in order to support and prove the proposed edgeless geometry, simulations of that scanner have been performed and lately reconstructed showing the advantages of the design.