[Nodular alveolar pattern of presentation for amiodarone pulmonary toxicity]. / Patrón alveolar nodular como forma de presentación de la toxicidad pulmonar por amiodarona.

Amiodarone is a triiodinated antiarrhythmic drug that accumulates in alveolar macrophages. Its use is limited by its high rate of associated pulmonary toxicity, estimated at 5-7%. Radiologic findings for pulmonary toxicity caused by amiodarone are unspecific and varied. The most common finding is subpleural reticular-type interstitial thickening, predominately in the bases of the lungs. However, the presence of parenchymal nodules is an uncommon presentation. We report the case of a woman treated with amiodarone that presented multiple nodular lesions at plain-film radiography and high-resolution CT that were compatible with pulmonary toxicity caused by amiodarone at pathologic examination.

Patrón alveolar nodular como forma de presentación de la toxicidad pulmonar por amiodarona / Nodular alveolar pattern of presentation for amiodarone pulmonary toxicity

La amiodarona es un antiarrítmico triyodado que se deposita en los macrófagos alveolares, cuyo uso se ve limitado por su toxicidad pulmonar que presenta una incidencia estimada del 5-7%. Los hallazgos radiológicos de la toxicidad pulmonar por amiodarona son inespecíficos y variados, siendo el más frecuente un engrosamiento intersticial de tipo reticular subpleural de predominio en bases. La presencia de nódulos parenquimatosos es, sin embrago, una forma infrecuente de presentación de esta entidad. Exponemos el caso de una mujer en tratamiento con amiodarona que presentaba en la radiología simple de tórax y tomografía computarizada (TC) de alta resolución múltiples lesiones nodulares cuyo posterior estudio anatomopatológico confirmaba su compatibilidad con toxicidad pulmonar por amiodarona

Amiodarone is a triiodinated antiarrhythmic drug that accumulates in alveolar macrophages. Its use is limited by its high rate of associated pulmonary toxicity, estimated at 5-7%. Radiologic findings for pulmonary toxicity caused by amiodarone are unspecific and varied. The most common finding is subpleural reticular-type interstitial thickening, predominately in the bases of the lungs. However, the presence of parenchymal nodules is an uncommon presentation. We report the case of a woman treated with amiodarone that presented multiple nodular lesions at plain-film radiography and high-resolution CT that were compatible with pulmonary toxicity caused by amiodarone at pathologic examination

Recurrent massive pleural effusion as a late complication of radiotherapy in Hodgkin's disease.

We report a very unusual case of a patient with recurrent massive PEs eight years after mediastinal radiotherapy for HD, in which evidence of lymphomatous recurrence could not be demonstrated. The diagnosis of PE as a complication of radiation is presumptive, and other disorders causing PE must be excluded. This condition requires symptomatic treatment and a close follow-up of the patient.